Effect of CAR polymorphism on the pharmacokinetics of artemisinin in healthy Chinese subjects

Drug Metabolism and Pharmacokinetics

Volumn 30, Issue 1, 2015, Pages 123-126

  Zang, Meitong ^a   Zhao, Lixia ^b   Zhu, Fanping ^a   Li, Xinxiu ^a   Yang, Aijuan ^a   Xing, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Artemisinin; CAR; Genotype; Interindividual variability; Pharmacokinetics

Indexed keywords

ARTEMISININ; ARTEMISININ DERIVATIVE; DEOXYARTEMISININ; DRUG METABOLITE; PIPERAQUINE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2B6 PROTEIN, HUMAN; CYTOCHROME P450 2B6;

AREA UNDER THE CURVE; ARTICLE; CHINESE; CONSTITUTIVE ANDROSTANE RECEPTOR GENE; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EXPOSURE; DRUG METABOLISM; GENE MUTATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MUTATOR GENE; NORMAL HUMAN; PHARMACOGENETICS; PLASMA CONCENTRATION-TIME CURVE; RECEPTOR GENE; RECOMMENDED DRUG DOSE; REPEATED DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TIME TO MAXIMUM PLASMA CONCENTRATION; BLOOD; CHINA; CLINICAL TRIAL; DOSE RESPONSE; GENETICS; METABOLISM; ORAL DRUG ADMINISTRATION; TIME FACTOR;

ADMINISTRATION, ORAL; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; CHINA; CYTOCHROME P-450 CYP2B6; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HEALTHY VOLUNTEERS; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS;

EID: 84924974261     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.1016/j.dmpk.2014.10.008     Document Type: Article

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