A comparison of immunohistochemistry and mass spectrometry for determining the amyloid fibril protein from formalin-fixed biopsy tissue

Journal of Clinical Pathology

Volumn 68, Issue 4, 2015, Pages 314-317

  Gilbertson, Janet A ^a   Theis, Jason D ^b   Vrana, Julie A ^b   Lachmann, Helen ^a   Wechalekar, Ashutosh ^a   Whelan, Carol ^a   Hawkins, Philip N ^a   Dogan, Ahmet ^b   Gillmore, Julian D ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; CONGO RED; FORMALDEHYDE; BIOLOGICAL MARKER; FIXATIVE; PARAFFIN;

ALGORITHM; AMYLOIDOSIS; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; KIDNEY AMYLOIDOSIS; KIDNEY BIOPSY; LABORATORY DEVICE; LASER MICRODISSECTION; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEOMICS; TANDEM MASS SPECTROMETRY; BIOPSY; COMPARATIVE STUDY; LASER CAPTURE MICRODISSECTION; METABOLISM; PREDICTIVE VALUE; PROCEDURES; TISSUE FIXATION;

AMYLOID; AMYLOIDOSIS; BIOLOGICAL MARKERS; BIOPSY; FIXATIVES; FORMALDEHYDE; HUMANS; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; PARAFFIN EMBEDDING; PREDICTIVE VALUE OF TESTS; PROTEOMICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TISSUE FIXATION;

EID: 84924968885     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2014-202722     Document Type: Article

References (13)

1. Pepys MB. Amyloidosis. Annu Rev Med 2006;57:223-41.
2. Gillmore JD, Hawkins PN. Pathophysiology and treatment of systemic amyloidosis. Nat Rev Nephrol 2013;9:574-86.
3. Puchtler H, Sweat F, Levine M. On the binding of Congo red by amyloid. J Histochem Cytochem 1962;10:355-64.
4. Owen-Casey MP, Sim R, Cook HT, et al. Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies. J Clin Pathol 2014;67:661-6.
5. Linke RP. Routine use of amyloid typing on formalin-fixed Paraffin sections from 626 patients by immunohistochemistry. In: Picken MM, Herrera GA, eds. Amyloid and related disorders. New York: Humana Press, 2012:219-29.
6. Said SM, Sethi S, Valeri AM, et al. Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases. Clin J Am Soc Nephrol 2013;8:1515-23.
7. Silver MM, Hearn SA, Walton JC, et al. Immunogold quantitation of immunoglobulin light chains in renal amyloidosis and kappa light chain nephropathy. Am J Pathol 1990;136:997-1007.
8. Vrana JA, Gamez JD, Madden BJ, et al. Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood 2009;114:4957-9.
9. Linke RP. On typing amyloidosis using immunohistochemistry. Detailled illustrations, review and a note on mass spectrometry. Prog Histochem Cytochem 2012;47:61-132.
10. Tennent GA, Cafferty KD, Pepys MB, et al. Congo red overlay immunohistochemistry aids classification of amyloid deposits. In: Kyle RA, Gertz MA, eds. Amyloid and Amyloidosis 1998. Pearl River, New York: Parthenon Publishing, 1999:160-2.
11. Eulitz M, Weiss DT, Solomon A. Immunoglobulin heavy-chain-associated amyloidosis. Proc Natl Acad Sci USA 1990;87:6542-6.
12. Sethi S, Theis JD, Shiller SM, et al. Medullary amyloidosis associated with apolipoprotein A-IV deposition. Kidney Int 2012;81:201-6.
13. Haider I, Yang H. Atrial natriuretic factor type amyloid leading to restrictive cardiomyopathy. Chin Med J (Engl) 2014;127:1399.