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Volumn 14, Issue 4, 2015, Pages 601-607

Pixantrone: A novel anthracycline-like drug for the treatment of non-Hodgkin lymphoma

Author keywords

Anthracyclines; Cardiotoxicity; Lymphoma; Pixantrone

Indexed keywords

BENDAMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; GEMCITABINE; METHYLPREDNISOLONE; PIXANTRONE; PREDNISOLONE; RITUXIMAB; VINCRISTINE; ANTINEOPLASTIC AGENT; ISOQUINOLINE DERIVATIVE;

EID: 84924959351     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.1010505     Document Type: Article
Times cited : (23)

References (41)
  • 1
    • 77957200763 scopus 로고    scopus 로고
    • Long-Term outcome of patients in the lnh-98.5 trial the first randomized study comparing rituximab-chop to standard chop chemotherapy in dlbcl patients: A study by the groupe detudes des lymphomes de ladulte
    • Coiffier B, Thieblemont C, Van Den Neste E, et al.Long-Term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe dEtudes des Lymphomes de lAdulte.Blood 2010; 116(12): 2040-5
    • (2010) Blood , vol.116 , Issue.12 , pp. 2040-2045
    • Coiffier, B.1    Thieblemont, C.2    Van Den Neste, E.3
  • 2
    • 45749152667 scopus 로고    scopus 로고
    • Phase ii study of dose-Adjusted epoch and rituximab in untreated diffuse large b-cell lymphoma with analysis of germinal center and postgerminal center biomarkers
    • Wilson WH, Dunleavy K, Pittaluga S, et al.Phase II study of dose-Adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and postgerminal center biomarkers.J Clin Oncol 2008; 26(16): 2717-24
    • (2008) J Clin Oncol , vol.26 , Issue.16 , pp. 2717-2724
    • Wilson, W.H.1    Dunleavy, K.2    Pittaluga, S.3
  • 3
    • 84875626098 scopus 로고    scopus 로고
    • Phase iii study of acvbp versus acvbp plus rituximab for patients with localized low-risk diffuse large b-cell lymphoma (lnh03-1b
    • Ketterer N, Coiffier B, Thieblemont C, et al.Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B).Ann Oncol 2013; 24(4): 1032-7
    • (2013) Ann Oncol , vol.24 , Issue.4 , pp. 1032-1037
    • Ketterer, N.1    Coiffier, B.2    Thieblemont, C.3
  • 4
    • 33645526451 scopus 로고    scopus 로고
    • Long-Term risk of cardiovascular disease after treatment for aggressive non-hodgkin lymphoma
    • Moser EC, Noordijk EM, van Leeuwen FE, et al.Long-Term risk of cardiovascular disease after treatment for aggressive non-Hodgkin lymphoma.Blood 2006; 107(7): 2912-19
    • (2006) Blood , vol.107 , Issue.7 , pp. 2912-2919
    • Moser, E.C.1    Noordijk, E.M.2    Van Leeuwen, F.E.3
  • 5
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • Singal PK, Iliskovic N.Doxorubicin-induced cardiomyopathy.N Engl J Med 1998; 339(13): 900-5
    • (1998) N Engl J Med , vol.339 , Issue.13 , pp. 900-905
    • Singal, P.K.1    Iliskovic, N.2
  • 6
    • 84895523455 scopus 로고    scopus 로고
    • Incidence and risk-factors of chop/rchop-related cardiotoxicity in patients with aggressive non-hodgkins lymphoma
    • Limat S, Daguindau E, Cahn J-Y, et al.Incidence and risk-factors of CHOP/RCHOP-related cardiotoxicity in patients with aggressive non-Hodgkins lymphoma.J Clin Pharm Ther 2014; 39(2): 168-74
    • (2014) J Clin Pharm Ther , vol.39 , Issue.2 , pp. 168-174
    • Limat, S.1    Daguindau, E.2    Cahn, J.-Y.3
  • 7
    • 3042698689 scopus 로고    scopus 로고
    • Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults
    • Hequet O, Le QH, Moullet I, et al.Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults.J Clin Oncol 2004; 22(10): 1864-71
    • (2004) J Clin Oncol , vol.22 , Issue.10 , pp. 1864-1871
    • Hequet, O.1    Le, Q.H.2    Moullet, I.3
  • 8
    • 0015849162 scopus 로고
    • A clinicopathologic analysis of adriamycin cardiotoxicity
    • Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA A clinicopathologic analysis of adriamycin cardiotoxicity.Cancer 1973; 32(2): 302-14
    • (1973) Cancer , vol.32 , Issue.2 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3    Gottlieb, J.A.4
  • 9
    • 84872719512 scopus 로고    scopus 로고
    • The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: Insight to explain the cardiac safety of pixantrone in doxorubicin-Treated patients
    • Salvatorelli E, Menna P, Paz OG, et al.The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-Treated patients.J Pharmacol Exp Ther 2013; 344(2): 467-78
    • (2013) J Pharmacol Exp Ther , vol.344 , Issue.2 , pp. 467-478
    • Salvatorelli, E.1    Menna, P.2    Paz, O.G.3
  • 10
    • 0017625476 scopus 로고
    • Time relationship between last dose of daunorubicin and congestive heart failure
    • Von Hoff DD, Layard M, Rozencweig M, Muggia FM.Time relationship between last dose of daunorubicin and congestive heart failure.Cancer Treat Rep 1977; 61(7): 1411-13
    • (1977) Cancer Treat Rep , vol.61 , Issue.7 , pp. 1411-1413
    • Von Hoff, D.D.1    Layard, M.2    Rozencweig, M.3    Muggia, F.M.4
  • 11
    • 0017354816 scopus 로고
    • Daunomycin-induced cardiotoxicity in children and adults a review of 110 cases
    • Von Hoff DD, Rozencweig M, Layard M, et al.Daunomycin-induced cardiotoxicity in children and adults A review of 110 cases.Am J Med 1977; 62(2): 200-8
    • (1977) Am J Med , vol.62 , Issue.2 , pp. 200-208
    • Von Hoff, D.D.1    Rozencweig, M.2    Layard, M.3
  • 12
    • 0017463876 scopus 로고
    • Adriamycin cardiotoxicity: Endomyocardial biopsy evidence of enhancement by irradiation
    • Billingham ME, Bristow MR, Glatstein E, et al. Adriamycin Cardiotoxicity: Endomyocardial Biopsy Evidence of Enhancement by Irradiation.Am J Surg Pathol 1977; 1(1): 17-23
    • (1977) Am J Surg Pathol , vol.1 , Issue.1 , pp. 17-23
    • Billingham, M.E.1    Bristow, M.R.2    Glatstein, E.3
  • 13
    • 0018650543 scopus 로고
    • Adriamycin cardiotoxicity: A survey of 1273 patients
    • Praga C, Beretta G, Vigo PL, et al.Adriamycin cardiotoxicity: a survey of 1273 patients.Cancer Treat Rep 1979; 63(5): 827-34
    • (1979) Cancer Treat Rep , vol.63 , Issue.5 , pp. 827-834
    • Praga, C.1    Beretta, G.2    Vigo, P.L.3
  • 14
    • 84945703491 scopus 로고
    • Hyperthermia potentiates doxorubicinrelated cardiotoxic effects
    • Kim YD, Lees DE, Lake CR, et al.Hyperthermia potentiates doxorubicinrelated cardiotoxic effects.JAMA 1979; 241(17): 1816-17
    • (1979) JAMA , vol.241 , Issue.17 , pp. 1816-1817
    • Kim, Y.D.1    Lees, D.E.2    Lake, C.R.3
  • 16
    • 0016161438 scopus 로고
    • Pharmacokinetics of adriamycin (nsc-123127) in patients with sarcomas
    • Benjamin RS.Pharmacokinetics of adriamycin (NSC-123127) in patients with sarcomas.Cancer Chemother Rep 1974; 58(2): 271-3
    • (1974) Cancer Chemother Rep , vol.58 , Issue.2 , pp. 271-273
    • Benjamin, R.S.1
  • 17
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • Minotti G, Menna P, Salvatorelli E, et al.Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity.Pharmacol Rev 2004; 56(2): 185-229
    • (2004) Pharmacol Rev , vol.56 , Issue.2 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3
  • 18
    • 0027772910 scopus 로고
    • Concentrations of doxorubicin and its metabolites in human autopsy heart and other tissues
    • Stewart DJ, Grewaal D, Green RM, et al.Concentrations of doxorubicin and its metabolites in human autopsy heart and other tissues.Anticancer Res 1993; 13(6A): 1945-52
    • (1993) Anticancer Res , vol.13 , Issue.6 , pp. 1945-1952
    • Stewart, D.J.1    Grewaal, D.2    Green, R.M.3
  • 19
    • 0020520269 scopus 로고
    • Comparative cardiac oxygen radical metabolism by anthracycline antibiotics, mitoxantrone, bisantrene, 4-(9-Acridinylamino)-methanesulfon-m-Anisidide, and neocarzinostatin
    • Doroshow JH, Davies KJ.Comparative cardiac oxygen radical metabolism by anthracycline antibiotics, mitoxantrone, bisantrene, 4-(9-Acridinylamino)-methanesulfon-m-Anisidide, and neocarzinostatin.Biochem Pharmacol 1983; 32(19): 2935-9
    • (1983) Biochem Pharmacol , vol.32 , Issue.19 , pp. 2935-2939
    • Doroshow, J.H.1    Davies, K.J.2
  • 20
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • Gewirtz DA A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.Biochem Pharmacol 1999; 57(7): 727-41
    • (1999) Biochem Pharmacol , vol.57 , Issue.7 , pp. 727-741
    • Gewirtz, D.A.1
  • 22
    • 81855225220 scopus 로고    scopus 로고
    • Anthracycline-related cardiomyopathy after childhood cancer: Role of polymorphisms in carbonyl reductase genes - A report from the childrens oncology group
    • Blanco JG, Sun C-L, Landier W, et al.Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes - A report from the Childrens Oncology Group.J Clin Oncol 2012; 30(13): 1415-21
    • (2012) J Clin Oncol , vol.30 , Issue.13 , pp. 1415-1421
    • Blanco, J.G.1    Sun, C.-L.2    Landier, W.3
  • 23
    • 33846425322 scopus 로고    scopus 로고
    • Defective taxane stimulation of epirubicinol formation in the human heart: Insight into the cardiac tolerability of epirubicin-Taxane chemotherapies
    • Salvatorelli E, Menna P, Gianni L, Minotti G.Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-Taxane chemotherapies.J Pharmacol Exp Ther 2007; 320(2): 790-800
    • (2007) J Pharmacol Exp Ther , vol.320 , Issue.2 , pp. 790-800
    • Salvatorelli, E.1    Menna, P.2    Gianni, L.3    Minotti, G.4
  • 24
    • 0029162440 scopus 로고
    • Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-hodgkins lymphoma using chop versus cnop chemotherapy
    • Sonneveld P, de Ridder M, van der Lelie H, et al.Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkins lymphoma using CHOP versus CNOP chemotherapy.J Clin Oncol 1995; 13(10): 2530-9
    • (1995) J Clin Oncol , vol.13 , Issue.10 , pp. 2530-2539
    • Sonneveld, P.1    De Ridder, M.2    Van Der Lelie, H.3
  • 25
    • 0026127460 scopus 로고
    • Mitoxantrone a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
    • Faulds D, Balfour JA, Chrisp P, Langtry HD.Mitoxantrone A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer.Drugs 1991; 41(3): 400-49
    • (1991) Drugs , vol.41 , Issue.3 , pp. 400-449
    • Faulds, D.1    Balfour, J.A.2    Chrisp, P.3    Langtry, H.D.4
  • 26
    • 84896479365 scopus 로고    scopus 로고
    • Tolerability and toxicological profile of pixantrone (pixuvri) in juvenile mice comparative study with doxorubicin
    • Longo M, Della Torre P, Allievi C, et al.Tolerability and toxicological profile of pixantrone (Pixuvri) in juvenile mice.Comparative study with doxorubicin.Reprod Toxicol 2014; 46: 20-30
    • (2014) Reprod Toxicol , vol.46 , pp. 20-30
    • Longo, M.1    Della Torre, P.2    Allievi, C.3
  • 27
    • 34248642248 scopus 로고    scopus 로고
    • Pixantrone (bbr 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: Comparative studies against doxorubicin and mitoxantrone
    • Cavalletti E, Crippa L, Mainardi P, et al.Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone.Invest New Drugs 2007; 25(3): 187-95
    • (2007) Invest New Drugs , vol.25 , Issue.3 , pp. 187-195
    • Cavalletti, E.1    Crippa, L.2    Mainardi, P.3
  • 28
    • 84878201628 scopus 로고    scopus 로고
    • The european medicines agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-hodgkins b-cell lymphomas: Summary of the scientific assessment of the committee for medicinal products for human use
    • Péan E, Flores B, Hudson I, et al.The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkins B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use.Oncologist 2013; 18(5): 625-33
    • (2013) Oncologist , vol.18 , Issue.5 , pp. 625-633
    • Péan, E.1    Flores, B.2    Hudson, I.3
  • 29
    • 84863113681 scopus 로고    scopus 로고
    • Pixantrone dimaleate versus other chemotherapeutic agents as a single-Agent salvage treatment in patients with relapsed or refractory aggressive non-hodgkin lymphoma: A phase 3 multicentre open-label randomised trial
    • Pettengell R, Coiffier B, Narayanan G, et al.Pixantrone dimaleate versus other chemotherapeutic agents as a single-Agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial.Lancet Oncol 2012; 13(7): 696-706
    • (2012) Lancet Oncol , vol.13 , Issue.7 , pp. 696-706
    • Pettengell, R.1    Coiffier, B.2    Narayanan, G.3
  • 30
    • 34247882156 scopus 로고    scopus 로고
    • A phase i/ii trial of pixantrone (bbr2778), methylprednisolone, cisplatin, and cytosine arabinoside (pshap) in relapsed/refractory aggressive non-hodgkins lymphoma
    • Lim S-T, Fayad L, Tulpule A, et al A phase I/II trial of pixantrone (BBR2778), methylprednisolone, cisplatin, and cytosine arabinoside (PSHAP) in relapsed/refractory aggressive non-Hodgkins lymphoma.Leuk Lymphoma 2007; 48(2): 374-80
    • (2007) Leuk Lymphoma , vol.48 , Issue.2 , pp. 374-380
    • Lim, S.-T.1    Fayad, L.2    Tulpule, A.3
  • 31
    • 79953173980 scopus 로고    scopus 로고
    • Phase i/ii study of pixantrone in combination with cyclophosphamide vincristine and prednisone in patients with relapsed aggressive non-hodgkin lymphoma
    • Borchmann P, Herbrecht R, Wilhelm M, et al.Phase I/II study of pixantrone in combination with cyclophosphamide, vincristine, and prednisone in patients with relapsed aggressive non-Hodgkin lymphoma.Leuk Lymphoma 2011; 52(4): 620-8
    • (2011) Leuk Lymphoma , vol.52 , Issue.4 , pp. 620-628
    • Borchmann, P.1    Herbrecht, R.2    Wilhelm, M.3
  • 32
    • 84884724017 scopus 로고    scopus 로고
    • Comparison of pixantrone-based regimen (cpop-r) with doxorubicinbased therapy (chop-r) for treatment of diffuse large b-cell lymphoma
    • Herbrecht R, Cernohous P, Engert A, et al.Comparison of pixantrone-based regimen (CPOP-R) with doxorubicinbased therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma.Ann Oncol 2013; 24(10): 2618-23
    • (2013) Ann Oncol , vol.24 , Issue.10 , pp. 2618-2623
    • Herbrecht, R.1    Cernohous, P.2    Engert, A.3
  • 33
    • 37249013214 scopus 로고    scopus 로고
    • linicalTrials.gov Internet Available from Cited 24 January 2014
    • ClinicalTrials.gov.ClinicalTrials.gov [Internet] Available from: http://www.clinicaltrial.gov/.[Cited 24 January 2014
    • ClinicalTrials.gov
  • 34
    • 80054725458 scopus 로고    scopus 로고
    • Pixantrone dimaleate in combination with fludarabine dexamethasone and rituximab in patients with relapsed or refractory indolent non-hodgkin lymphoma: Phase 1 study with a dose-expansion cohort
    • Srokowski TP, Liebmann JE, Modiano MR, et al.Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: phase 1 study with a dose-expansion cohort.Cancer 2011; 117(22): 5067-73
    • (2011) Cancer , vol.117 , Issue.22 , pp. 5067-5073
    • Srokowski, T.P.1    Liebmann, J.E.2    Modiano, M.R.3
  • 35
    • 0035136099 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of the novel aza-Anthracenedione compound bbr 2778 in patients with advanced solid malignancies
    • Faivre S, Raymond E, Boige V, et al A phase I and pharmacokinetic study of the novel aza-Anthracenedione compound BBR 2778 in patients with advanced solid malignancies.Clin Cancer Res 2001; 7(1): 43-50
    • (2001) Clin Cancer Res , vol.7 , Issue.1 , pp. 43-50
    • Faivre, S.1    Raymond, E.2    Boige, V.3
  • 36
    • 84862774641 scopus 로고    scopus 로고
    • Bendamustine with or without rituximab for the treatment of heavily pretreated non-hodgkins lymphoma patients: A multicenter retrospective study on behalf of the italian lymphoma foundation (fil
    • Rigacci L, Puccini B, Cortelazzo S, et al.Bendamustine with or without rituximab for the treatment of heavily pretreated non-Hodgkins lymphoma patients: A multicenter retrospective study on behalf of the Italian Lymphoma Foundation (FIL). Ann hematol 2012; 91(7): 1013-22
    • (2012) Ann Hematol , vol.91 , Issue.7 , pp. 1013-1022
    • Rigacci, L.1    Puccini, B.2    Cortelazzo, S.3
  • 38
    • 33747693088 scopus 로고    scopus 로고
    • Liposomal encapsulated doxorubicin (caelyx) in the treatment of relapsed aggressive non-hodgkins lymphoma: A phase ii study
    • Macpherson N, Belch A, Taylor M, et al.Liposomal encapsulated doxorubicin (Caelyx) in the treatment of relapsed aggressive non-Hodgkins lymphoma: a phase II study.Leuk Lymphoma 2006; 47(7): 1327-32
    • (2006) Leuk Lymphoma , vol.47 , Issue.7 , pp. 1327-1332
    • MacPherson, N.1    Belch, A.2    Taylor, M.3
  • 39
    • 0036327594 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin in the chop regimen for older patients with aggressive (stages iii/iv) non-hodgkins lymphoma
    • Tsavaris N, Kosmas C, Vadiaka M, et al.Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkins lymphoma.Anticancer Res 2002; 22(3): 1845-8
    • (2002) Anticancer Res , vol.22 , Issue.3 , pp. 1845-1848
    • Tsavaris, N.1    Kosmas, C.2    Vadiaka, M.3
  • 40
    • 0034988022 scopus 로고    scopus 로고
    • Phase i study of bbr 2778, a new aza-Anthracenedione, in advanced or refractory non-hodgkins lymphoma
    • Borchmann P, Schnell R, Knippertz R, et al.Phase I study of BBR 2778, a new aza-Anthracenedione, in advanced or refractory non-Hodgkins lymphoma.Ann Oncol 2001; 12(5): 661-7
    • (2001) Ann Oncol , vol.12 , Issue.5 , pp. 661-667
    • Borchmann, P.1    Schnell, R.2    Knippertz, R.3
  • 41
    • 0033711725 scopus 로고    scopus 로고
    • A clinical phase i and pharmacokinetic study of bbr 2778, a novel anthracenedione analogue, administered intravenously, 3 weekly
    • Dawson LK, Jodrell DI, Bowman A, et al A clinical phase I and pharmacokinetic study of BBR 2778, a novel anthracenedione analogue, administered intravenously, 3 weekly.Eur J Cancer 2000; 36(18): 2353-9
    • (2000) Eur J Cancer , vol.36 , Issue.18 , pp. 2353-2359
    • Dawson, L.K.1    Jodrell, D.I.2    Bowman, A.3


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