In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams

Acta Biomaterialia

Volumn 12, Issue 1, 2015, Pages 242-249

  Kovtun, Anna ^a   Goeckelmann, Melanie J ^a   Niclas, Antje A ^b   Montufar, Edgar B ^c   Ginebra, Maria Pau ^c   Planell, Josep A ^c,d   Santin, Matteo ^e   Ignatius, Anita ^a  

^a UNIVERSITY OF ULM   (Germany)

^b Military Hospital Ulm   (Germany)

^c UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^d INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^e UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

Bone regeneration; Calcium phosphate cement; Gelatine; Rabbit model; Soybean

Indexed keywords

BIOCOMPATIBILITY; BONE; BONE CEMENT; CALCIUM PHOSPHATE; CEMENTS; DEFECTS; DEGRADATION; SETTING;

BONE DEFECT; BONE FORMATION; BONE REGENERATION; CALCIUM PHOSPHATE CEMENT; DEGRADATION RATE; GELATIN; IN-VIVO; PERFORMANCE; RABBIT MODELS; SOYBEAN;

HYDROXYAPATITE;

GELATIN; HYDROXYAPATITE; SOYBEAN EXTRACT; BIOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIOMECHANICS; BONE DENSITY; BONE MARROW; CALCIUM PHOSPHATE CERAMIC; COMPARATIVE STUDY; CONTROLLED STUDY; DEGRADATION; EXPERIMENTAL RABBIT; FEMALE; FEMUR CONDYLE; FOAM; GIANT CELL; IN VIVO STUDY; INJECTION; MACROPHAGE; MATERIALS HANDLING; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOID; PRIORITY JOURNAL; RIGIDITY; TRABECULAR BONE; ANIMAL; CHEMISTRY; RABBIT; SOYBEAN; X RAY DIFFRACTION;

GLYCINE MAX; ORYCTOLAGUS CUNICULUS;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMECHANICAL PHENOMENA; DURAPATITE; FEMALE; GELATIN; RABBITS; SOYBEANS; X-RAY DIFFRACTION;

EID: 84924953194     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.10.034     Document Type: Article

References (31)

1. Dorozhkin SV, Epple M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed 2002;41:3130-46.
2. Ginebra MP, Espanol M, Montufar EB, Perez RA, Mestres G. New processing approaches in calcium phosphate cements and their applications in regenerative medicine. Acta Biomater 2010;6:2863-73.
3. Ginebra MP, Delgado JA, Harr I, Almirall A, Del Valle S, Planell JA. Factors affecting the structure and properties of an injectable self-setting calcium phosphate foam. J Biomed Mater Res A 2007;80:351-61.
4. Del Valle S, Mino N, Munoz F, Gonzalez A, Planell JA, Ginebra MP. In vivo evaluation of an injectable macroporous calcium phosphate cement. J Mater Sci Mater Med 2007;18:353-61.
5. Montufar EB, Traykova T, Planell JA, Ginebra MP. Comparison of a low molecular weight and a macromolecular surfactant as foaming agents for injectable self setting hydroxyapatite foams: polysorbate 80 versus gelatin. Mater Sci Eng 2011;31:1498-504.
6. Djagny VB, Wang Z, Xu S. Gelatin: a valuable protein for food and pharmaceutical industries: review. Crit Rev Food Sci Nutr 2001;41:481-92.
7. Perut F, Montufar EB, Ciapetti G, Santin M, Salvage J, Traykova T, et al. Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response. Acta Biomater 2011;7:1780-7.
8. Murkies AL, Wilcox G, Davis SR. Clinical review 92: phytoestrogens. J Clin Endocrinol Metab 1998;83:297-303.
9. Rickard DJ, Monroe DG, Ruesink TJ, Khosla S, Riggs BI, Spelsberg TC. Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta. J Cell Biochem 2003;89:633-46.
10. Middleton Jr E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
11. Santin M, Morris C, Standen G, Nicolais L, Ambrosio L. A new class of bioactive and biodegradable soybean-based bone fillers. Biomacromolecules 2007;8:2706-11.
12. Giavaresi G, Fini M, Salvage J, NicoliAldini N, Giardino R, Ambrosio L, et al. Bone regeneration potential of a soybean-based filler: experimental study in a rabbit cancellous bone defects. J Mater Sci Mater Med 2010;21:615-26.
13. Santin M, Ambrosio L. Soybean-based biomaterials: preparation, properties and tissue regeneration potential. Expert Rev Med Devices 2008;5:349-58.
14. Kanter B, Geffers M, Ignatius A, Gbureck U. Control of in vivo mineral bone cement degradation. Acta Biomater 2014;10:3279-87.
15. Ignatius AA, Betz O, Augat P, Claes LE. In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes. J Biomed Mater Res A 2001;58:701-9.
16. Ginebra MP, Fernandez E, De Maeyer EA, Verbeeck RM, Boltong MG, Ginebra J, et al. Setting reaction and hardening of an apatitic calcium phosphate cement. J Dent Res 1997;76:905-12.
17. Rodrigues CV, Serricella P, Linhares AB, Guerdes RM, Borojevic R, Rossi MA, et al. Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineering. Biomaterials 2003;24:4987-97.
18. Rohanizadeh R, Swain MV, Mason RS. Gelatin sponges (Gelfoam) as a scaffold for osteoblasts. J Mater Sci Mater Med 2008;19:1173-82.
19. Zhang X, Cai Q, Liu H, Zhang S, Wei Y, Yang X, et al. Calcium ion release and osteoblastic behavior of gelatin/beta-tricalcium phosphate composite nanofibers fabricated by electrospinning. Mater Lett 2012;73:172-5.
20. Huang Y, Yan Y, Pang X, Ding Q, Han S. Bioactivity and corrosion properties of gelatin-containing and strontium-doped calcium phosphate composite coating. Appl Surf Sci 2013;282:583-9.
21. Montufar EB, Traykova T, Schacht E, Ambrosio L, Santin M, Planell JA, et al. Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration. J Mater Sci Mater Med 2010;21:863-9.
22. Link DP, van den Dolder J, van den Beucken JJ, Habraken W, Soede A, Boerman OC, et al. Evaluation of an orthotopically implanted calcium phosphate cement containing gelatin microparticles. J Biomed Mater Res 2009;90:372-9.
23. Habraken WJEM, Wolke JGC, Mikos AG, Jansen JA. Porcine gelatin microsphere/calcium phosphate cement composites: An in vitro degradation study. J Biomed Mater Res B Appl Biomater 2009;91:555-61.
24. Bourgeois B, Laboux O, Obadia L, Gauthier O, Betti E, Aguado E, et al. Calcium-deficient apatite: a first in vivo study concerning bone ingrowth. J Biomed Mater Res A 2003;65:402-8.
25. Keller J, Brink S, Busse B, Schilling AF, Schinke T, Amling M, et al. Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay. PLoS ONE 2012;7:e46757.
26. Zhang Z, Egaña JT, Reckhenrich AK, Schenck TL, Lohmeyer JA, Schantz JT, et al. Cell-based resorption assays for bone graft substitutes. Acta Biomater 2012;8:13-9.
27. Asahina I, Watanabe M, Sakurai N, Mori M, Enomoto S. Repair of bone defect in primate mandible using a bone morphogenetic protein (BMP)-hydroxyapatite-collagen composite. J Med Dent Sci 1997;44:63-70.
28. Liao H, Walboomers XF, Habraken WJ, Zhang Z, Li Y, Grijpma DW, et al. Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect. Acta Biomater 2011;7:1752-9.
29. Matsumoto G, Sugita Y, Kubo K, Yoshida W, Ikada Y, Sobajima S, et al. Gelatin powders accelerate the resorption of calcium phosphate cement and improve healing in the alveolar ridge. J Biomater Appl 2014;28:1316-24.
30. Gil-Albarova J, Vila M, Badiola-Vargas J, Sánchez-Salcedo S, Herrera A, Vallet-Regi M. In vivo osteointegration of three-dimensional crosslinked gelatin-coated hydroxyapatite foams. Acta Biomater 2012;8:3777-83.
31. Schlichting K, Schell H, Kleemann RU, Schill A, Weiler A, Duda GN, et al. Influence of scaffold stiffness on subchondral bone and subsequent cartilage regeneration in an ovine model of osteochondral defect healing. Am J Sports Med 2008;36:2379-91.