Early goal-directed therapy did not reduce mortality more than usual care in early septic shock

Annals of Internal Medicine

Volumn 162, Issue 6, 2015, Pages JC4-

  Muck, Andrew ^a   Adams, Bruce D ^a   Howe, B ^b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b Australian and New Zealand Intensive Care Research Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; HYPERTENSIVE FACTOR; VASOCONSTRICTOR AGENT;

CLINICAL PROTOCOL; EARLY GOAL DIRECTED THERAPY; EARLY INTERVENTION; EMERGENCY WARD; FLUID RESUSCITATION; HEALTH CARE; HEALTH CARE FACILITY; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; MORTALITY; NOTE; PATIENT CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPTIC SHOCK; SURVIVAL; TIME TO TREATMENT; FEMALE; FLUID THERAPY; MALE; SHOCK, SEPTIC;

FEMALE; FLUID THERAPY; HUMANS; MALE; SHOCK, SEPTIC; VASOCONSTRICTOR AGENTS;

EID: 84924891310     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/ACPJC-2015-162-6-004     Document Type: Note

References (4)

1. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
2. ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014; 370:1683-93.
3. Lagu T, Rothberg MB, Shieh MS, et al. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 2012;40:754-61.
4. Gaieski DF, Mikkelsen ME, Band RA, et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goaldirected therapy was initiated in the emergency department. Crit Care Med. 2010;38:1045-53.