Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants

Nutrients

Volumn 6, Issue 12, 2014, Pages 5636-5651

  Esamai, Fabian ^a   Liechty, Edward ^b   Ikemeri, Justus ^a   Westcott, Jamie ^c   Kemp, Jennifer ^c   Culbertson, Diana ^c   Miller, Leland V ^c   Hambidge, K Michael ^c   Krebs, Nancy F ^c  

^a MOI UNIVERSITY   (Kenya)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Children's Hospital Colorado   (United States)

Author keywords

Iron supplementation; Kenya; Malaria; Micronutrient powders; Zinc absorption

Indexed keywords

ASCORBIC ACID; C REACTIVE PROTEIN; FERRITIN; FOLIC ACID; HEMOGLOBIN; IRON; ISOTOPE; OROSOMUCOID; RETINOL; TRACE ELEMENT; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ZINC; ZINC 68; POWDER;

ABSORPTION; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN EXPERIMENT; INFANT; MAIZE; MALE; MASS SPECTROMETRY; MICRONUTRIENT POWDER; NEPHELOMETRY; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; URINALYSIS; ZINC BLOOD LEVEL; CHILD DEVELOPMENT; DIETARY REFERENCE INTAKE; GASTROINTESTINAL ABSORPTION; INFANT NUTRITION; KENYA; METABOLISM; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; ORAL DRUG ADMINISTRATION; POWDER; TIME; TREATMENT OUTCOME; WEIGHT GAIN;

ZEA MAYS;

ADMINISTRATION, ORAL; CHILD DEVELOPMENT; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; GASTROINTESTINAL ABSORPTION; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; IRON; KENYA; MICRONUTRIENTS; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; POWDERS; RECOMMENDED DIETARY ALLOWANCES; TIME FACTORS; TREATMENT OUTCOME; WEIGHT GAIN; ZINC;

EID: 84924874269     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6125636     Document Type: Article

References (45)

1. Sazawal, S.; Black, R.E.; Ramsan, M.; Chwaya, H.M.; Stoltzfus, R.J.; Dutta, A.; Dhingra, U.; Kabole, I.; Deb, S.; Othman, M.K., et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial. Lancet 2006, 367, 133-143.
2. World Health Organization. Conclusions and recommendations of the WHO Consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr. Bull. 2007, 28, 621-627.
3. Pasricha, S.R.; Drakesmith, H.; Black, J.; Hipgrave, D.; Biggs, B.A. Control of iron deficiency anemia in low- and middle-income countries. Blood 2013, 121, 2607-2617.
4. Iannotti, L.L.; Tielsch, J.M.; Black, M.M.; Black, R.E. Iron supplementation in early childhood: Health benefits and risks. Am. J. Clin. Nutr. 2006, 84, 1261-1276.
5. Fischer Walker, C.; Kordas, K.; Stoltzfus, R.J.; Black, R.E. Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials. Am. J. Clin. Nutr. 2005, 82, 5-12.
6. Hambidge, K.M.; Krebs, N.F.; Sibley, L.; English, J. Acute effects of iron therapy on zinc status during pregnancy. Obstet. Gynecol.1987, 70, 593-596.
7. Hambidge, K.M.; Krebs, N.F.; Jacobs, M.A.; Favier, A.; Guyette, L.; Ikle, D.N. Zinc nutritional status during pregnancy: A longitudinal study. Am. J. Clin. Nutr. 1983, 37, 429-442.
8. O’Brien, K.O.; Zavaleta, N.; Caulfield, L.E.; Yang, D.X.; Abrams, S.A. Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian women. Am. J. Clin. Nutr. 1999, 69, 509-515.
9. Fung, E.B.; Ritchie, L.D.; Woodhouse, L.R.; Roehl, R.; King, J.C. Zinc absorption in women during pregnancy and lactation: A longitudinal study. Am. J. Clin. Nutr. 1997, 66, 80-88.
10. Chung, C.S.; Nagey, D.A.; Veillon, C.; Patterson, K.Y.; Jackson, R.T.; Moser-Veillon, P.B. A single 60-mg iron dose decreases zinc absorption in lactating women. J. Nutr. 2002, 132, 1903-1905.
11. Harvey, L.J.; Dainty, J.R.; Hollands, W.J.; Bull, V.J.; Hoogewerff, J.A.; Foxall, R.J.; McAnena, L.; Strain, J.J.; Fairweather-Tait, S.J. Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women. Am. J. Clin. Nutr. 2007, 85, 131-136.
12. O’Brien, K.O.; Zavaleta, N.; Caulfield, L.E.; Wen, J.; Abrams, S.A. Prenatal iron supplements impair zinc absorption in pregnant Peruvian women. J. Nutr. 2000, 130, 2251-2255.
13. Davidsson, L.; Almgren, A.; Sandstrom, B.; Hurrell, R.F. Zinc absorption in adult humans: The effect of iron fortification. Br. J. Nutr.1995, 74, 417-425.
14. Fairweather-Tait, S.J.; Wharf, S.G.; Fox, T.E. Zinc absorption in infants fed iron-fortified weaning food. Am. J. Clin. Nutr. 1995, 62, 785-789.
15. Miller, L.V.; Krebs, N.F.; Hambidge, K.M. Mathematical model of zinc absorption: Effects of dietary calcium, protein and iron on zinc absorption. Br. J. Nutr.2013, 109, 695-700.
16. Friel, J.K.; Naake, V.L.; Miller, L.V.; Fennessey, P.V.; Hambidge, K.M. The analysis of stable isotopes in urine to determine the fractional absorption of zinc. Am. J. Clin. Nutr. 1992, 55, 473-477.
17. Miller, L.V.; Hambidge, K.M.; Naake, V.L.; Hong, Z.; Westcott, J.L.; Fennessey, P.V. Size of the zinc pools that exchange rapidly with plasma zinc in humans: Alternative techniques for measuring and relation to dietary zinc intake. J. Nutr. 1994, 124, 268-276.
18. Goudar, S.S.; Carlo, W.A.; McClure, E.M.; Pasha, O.; Patel, A.; Esamai, F.; Chomba, E.; Garces, A.; Althabe, F.; Kodkany, B., et al. The Maternal and Newborn Health Registry Study of the global network for womenʼs and childrenʼs health research. Int. J. Gynaecol. Obstetr. 2012, 118, 190-193.
19. Krebs, N.F.; Reidinger, C.J.; Miller, L.V.; Hambidge, K.M. Zinc homeostasis in breast-fed infants. Pediatr. Res. 1996, 39, 661-665.
20. Jalla, S.; Westcott, J.; Steirn, M.; Miller, L.V.; Bell, M.; Krebs, N.F. Zinc absorption and exchangeable zinc pool sizes in breast-fed infants fed meat or cereal as first complementary food. J. Pediatr. Gastroenterol. Nutr. 2002, 34, 35-41.
21. Gisore, P.; Shipala, E.; Otieno, K.; Rono, B.; Marete, I.; Tenge, C.; Mabeya, H.; Bucher, S.; Moore, J.; Liechty, E., et al. Community based weighing of newborns and use of mobile phones by village elders in rural settings in Kenya: A decentralised approach to health care provision. BMC Pregnancy Childbirth 2012, 12, doi:10.1186/1471-2393-12-15.
22. Krebs, N.F.; Westcott, J.E.; Culbertson, D.L.; Sian, L.; Miller, L.V.; Hambidge, K.M. Comparison of complementary feeding strategies to meet zinc requirements of older breastfed infants. Am. J. Clin. Nutr. 2012, 96, 30-35.
23. Krebs, N.; Miller, L.V.; Naake, V.L.; Lei, S.; Westcott, J.E.; Fennessey, P.V. The use of stable isotope techniques to assess zinc metabolism. J. Nutr. Biochem. 1995, 6, 292-307.
24. R Development Core Team. R: A Language and Environment for Statistical Computing. Available online: http://www.R-project.org (accessed on 17 July 2014).
25. Sandstrom, B.; Davidsson, L.; Cederblad, A.; Lonnerdal, B. Oral iron, dietary ligands and zinc absorption. J. Nutr. 1985, 115, 411-414.
26. Food and Nutrition Board Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc; National Academy Press: Washington, DC, USA, 2001; pp. 442-501.
27. Zlotkin, S.H.; Schauer, C.; Owusu Agyei, S.; Wolfson, J.; Tondeur, M.C.; Asante, K.P.; Newton, S.; Serfass, R.E.; Sharieff, W. Demonstrating zinc and iron bioavailability from intrinsically labeled microencapsulated ferrous fumarate and zinc gluconate Sprinkles in young children. J. Nutr. 2006, 136, 920-925.
28. Sheng, X.Y.; Hambidge, K.M.; Zhu, X.X.; Ni, J.X.; Bailey, K.B.; Gibson, R.S.; Krebs, N.F. Major variables of zinc homeostasis in Chinese toddlers. Am. J. Clin. Nutr. 2006, 84, 389-394.
29. Kodkany, B.S.; Bellad, R.M.; Mahantshetti, N.S.; Westcott, J.E.; Krebs, N.F.; Kemp, J.F.; Hambidge, K.M. Biofortification of pearl millet with iron and zinc in a randomized controlled trial increases absorption of these minerals above physiologic requirements in young children. J. Nutr. 2013, 143, 1489-1493.
30. Brown, K.H.; Engle-Stone, R.; Krebs, N.F.; Peerson, J.M. Dietary intervention strategies to enhance zinc nutrition: Promotion and support of breastfeeding for infants and young children. Food Nutr. Bull.2009, 30, 144-171.
31. Abrams, S.A.; Wen, J.; Stuff, J.E. Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants. Pediatr. Res. 1997, 41, 384-390.
32. Lindenmayer, G.W.; Stoltzfus, R.J.; Prendergast, A.J. Interactions between zinc deficiency and environmental enteropathy in developing countries. Adv. Nutr. 2014, 5, 1-6.
33. Manary, M.J.; Abrams, S.A.; Griffin, I.J.; Quimper, M.M.; Shulman, R.J.; Hamzo, M.G.; Chen, Z.S.; Maleta, K.; Manary, M.J. Perturbed zinc homeostasis in rural 3-5-year-old Malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy. Pediatr. Res.2010, 67, 671-675.
34. Hambidge, K.M.; Miller, L.V.; Westcott, J.E.; Sheng, X.; Krebs, N.F. Zinc bioavailability and homeostasis. Am. J. Clin. Nutr. 2010, 91, 1478-1483.
35. Hambidge, K.M.; Krebs, N.F.; Westcott, J.E.; Miller, L.V. Changes in zinc absorption during development. J. Pediatr. 2006, 149, 64-68.
36. Miller, L.V.; Hambidge, K.M.; Westcott, J.L.; Krebs, N.F. University of Colorado School of Medicine, Aurora, CO, USA. Unpublished work, 2014.
37. Prentice, A.M.; Doherty, C.P.; Abrams, S.A.; Cox, S.E.; Atkinson, S.H.; Verhoef, H.; Armitage, A.E.; Drakesmith, H. Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood 2012, 119, 1922-1928.
38. Pasricha, S.R.; Hayes, E.; Kalumba, K.; Biggs, B. Effect of daily iron supplementation on health in children aged 4-23 months: A systematic review and meta-analysis of randomised controlled trials. Lancet Glob. Health 2013, 1, 77-86.
39. Soofi, S.; Cousens, S.; Iqbal, S.P.; Akhund, T.; Khan, J.; Ahmed, I.; Zaidi, A.K.; Bhutta, Z.A. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial. Lancet 2013, 382, 29-40.
40. Krebs, N.F.; Sherlock, L.G.; Westcott, J.; Culbertson, D.; Hambidge, K.M.; Feazel, L.M.; Robertson, C.E.; Frank, D.N. Effects of different complementary feeding regimens on iron status and enteric microbiota in breastfed infants. J. Pediatr. 2013, 163, 416-423.
41. Zimmermann, M.B.; Chassard, C.; Rohner, F.; NʼGoran, E.K.; Nindjin, C.; Dostal, A.; Utzinger, J.; Ghattas, H.; Lacroix, C.; Hurrell, R.F. The effects of iron fortification on the gut microbiota in African children: A randomized controlled trial in Cote dʼIvoire. Am. J. Clin. Nutr. 2010, 92, 1406-1415.
42. Jaeggi, T.; Moretti, D.; Kvalsvig, J.; Holding, P.A.; Tjalsma, H.; Kortman, G.A.; Joosten, I.; Mwangi, A.; Zimmermann, M.B. Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. PLoS One2013, 8, doi:10.1371/journal.pone.0057513.
43. Jaeggi, T.; Kortman, G.A.; Moretti, D.; Chassard, C.; Holding, P.; Dostal, A.; Boekhorst, J.; Timmerman, H.M.; Swinkels, D.W.; Tjalsma, H., et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2014, 63, doi:10.1136/gutjnl-2014-307720.
44. World Health Organization. Trace Elements in Human Nutrition and Health; World Health Organization: Geneva, Switzerland, 1996; pp. 72-104.
45. International Zinc Nutrition Consultative Group. Overview of Zinc Nutrition; International Nutrition Foundation for United Nations University Press: Boston, MA, USA, 2004.