Cortical hypoexcitability persists beyond the symptomatic phase of a concussion

Brain Injury

Volumn 28, Issue 4, 2014, Pages 465-471

  Powers, Kaley C ^a   Cinelli, Michael E ^a   Kalmar, Jayne M ^a  

^a WILFRID LAURIER UNIVERSITY   (Canada)

Author keywords

Concussion; Evoked potentials; Sport

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; FACILITATION; FOOTBALL; FORCE; HUMAN; MOTOR CORTEX; MUSCLE TWITCH; NEUROMUSCULAR FUNCTION; OUTCOME ASSESSMENT; POSTCONCUSSION SYNDROME; TRANSCRANIAL MAGNETIC STIMULATION; ATHLETE; BRAIN CONCUSSION; EXCITATION CONTRACTION COUPLING; MALE; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; SKELETAL MUSCLE; YOUNG ADULT;

ATHLETES; BRAIN CONCUSSION; EVOKED POTENTIALS, MOTOR; EXCITATION CONTRACTION COUPLING; FOOTBALL; HUMANS; ISOMETRIC CONTRACTION; MALE; MOTOR CORTEX; MUSCLE, SKELETAL; TRANSCRANIAL MAGNETIC STIMULATION; YOUNG ADULT;

EID: 84924838767     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2014.888759     Document Type: Article

References (30)

1. McCrory P, Meeuwisse W, Johnston KM, Dvorak J, Aubry M, Molloy M, Cantu R. Consensus statement on concussion in sportthe 3rd International Conference on concussion in sport, held in Zurich, November 2008. Journal of Clinical Neuroscience 2009;16:755-763
2. McCrea M, Guskiewicz KM, Marshall SW, Barr W, Randolph C, Cantu RC, Onate JA, Yang J, Kelly JP. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. Journal of American Medical Association 2003; 290:2556-2563
3. De Beaumont L, Henry LC, Gosselin N. Long-Term functional alterations in sports concussion. Neurosurgical Focus 2012;33:1-7
4. Aubry M, Cantu RC, Dvorak J, Graf-Baumann T, Johnston KM, Kelly J, Lovell M, McCrory P, Meeuwisse W, Schamasch P. Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001. British Journal of Sports Medicine 2002;36:6-10
5. Giza C, Hovda DA. The neurometabolic cascade of concussion. Journal of Athletic Training 2001;36:228-235
6. De Beaumont L, Lassonde M, Leclerc S, Theoret H. Long-Term and cumulative effects of sports concussion on motor cortex inhibition. Neurosurgery 2007;61:329-337
7. Tremblay S, De Beaumont L, Lassonde M, Theoret H. Evidence for the specificity of intracortical inhibitory dysfunction in asymptomatic concussed athletes. Journal of Neurotrauma 2011;28:493-502
8. De Beaumont L, Theoret H, Mongeon D, Messier J, Leclerc S, Tremblay S, Ellemberg D, Lassonde M. Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood. Brain 2009;132:695-708
9. De Beaumont L, Mongeon D, Tremblay S, Messier J, Prince F, Leclerc S, Lassonde M, Theoret H. Persistent motor system abnormalities in formerly concussed athletes. Journal of Athletic Training 2011;46:234-240
10. Tallus J, Lioumis P, Hamalainen H, Kahkonen S, Tenovuo O. Long-lasting TMS motor threshold elevation in mild traumatic brain injury. Acta Neurologica Scandinavica 2012;126:178-182
11. Bernabeu M, Demirtas-Tatlidede A, Opisso E, Lopez R, Tormos J, Pascual-Leone A. Abnormal corticospinal excitability in traumatic diffuse axonal brain injury. Journal of Neurotrauma 2009;26: 2185-2193
12. Chistyakov AV, Soustiel JF, Hafner H, Trubnik M, Levy G, Feinsod M. Excitatory and inhibitory corticospinal responses to transcranial magnetic stimulation in patients with minor to moderate head injury. Journal of Neurology, Neurosurgery, and Psychiatry 2001;70:580-587
13. Livingston SC, Saliba EN, Goodkin HP, Barth JT, Hertel JN, Ingersoll CD. A preliminary investigation of motor evoked potential abnormalities following sport-related concussion. Brain Injury 2010;24:904-913
14. Livingston SC, Goodkin HP, Hertel JN, Saliba EN, Barth JT, Ingersoll CD. Differential rates of recovery after acute sport-related concussion: electrophysiologic, symptomatic and neurocognitive indices. Journal of Clinical Neurophysiology 2012;29:23-32
15. Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clinical Neurophysiology 2009;120:2008-2039
16. Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD. Corticocortical inhibition in human motor cortex. Journal of Physiology 1993;471: 501-519
17. Todd G, Taylor JL, Gandevia SC. Reproducible measurement of voluntary activation of human elbow flexors with motor cortical stimulation. Journal of Applied Physiology 2004;97: 236-242
18. Daskalakis ZJ, Molnar GF, Christensen BK, Sailer A, Fitzgerald PB, Chen R. An automated method to determine the transcranial magnetic stimulation-induced contralateral silent period. Clinical Neurophysiology 2003;114:938-944
19. Plaskett CJ, Cafarelli E. Caffeine increases endurance and attenuates force sensation during submaximal isometric contractions. Journal of Applied Physiology 2001;91:1535-1544
20. Vaillancourt DE, Slifkin AB, Newell KM. Visual control of isometric force in Parkinsons disease. Neuropsychologia 2001;39: 1410-1418
21. Ziemann U. Pharmacology of TMS. Supplements of Clinical Neurophysiology 2003;56:226-231
22. Ziemann U. TMS and drugs. Clinical Neurophysiology 2004;115: 1717-1729
23. Stagg CJ, Bestmann S, Constantinescu a O, Moreno LM, Allman C, Mekle R, Woolrich M, Near J, Johansen-Berg H, Rothwell JC. Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex. The Journal of Physiology 2011;589:5845-5855
24. Tremblay S, Beaule V, Proulx S, De Beaumont L, Marjanska M, Doyon J, Pascual-Leone A, Lassonde M, Theoret H. Relationship between transcranial magnetic stimulation measures of intracortical inhibition and spectroscopy measures of GABA and glutamate+ glutamine. Journal of Neurophysiology 2013;109:1343-1349
25. Jones LA. The sense of effort and force during fatiguing contractions. Advances in Experimental Medicine and Biology 1995;384: 305-313
26. Jones LA, Hunter IW. Effect of fatigue on force sensation. Experimental Neurology 1983;81:640-650
27. Guskiewicz KM, Ross SE, Marshall SW. Postural stability and neuropsychological deficits after concussion in collegiate athletes. Journal of Athletic Training 2001;36:263-273
28. Welsh SJ, Dinenno DV, Tracy BL. Variability of quadriceps femoris motor neuron discharge and muscle force in human aging. Experimental Brain Research 2007;179:219-233
29. Kennedy DM, Christou EA. Greater amount of visual information exacerbates force control in older adults during constant isometric contractions. Experimental Brain Research 2011;213: 351-361
30. Tracy BL. Visuomotor contribution to force variability in the plantarflexor and dorsiflexor muscles. Human Movement Science 2008;26:796-807.