Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings

International Wound Journal

Volumn 11, Issue 5, 2014, Pages 517-522

  Huang, Chenyu ^a,b   Akaishi, Satoshi ^a,c   Hyakusoku, Hiko ^a   Ogawa, Rei ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Meitan General Hospital   (China)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Fibroproliferation; Hypertrophic scar; Inflammation; Keloid; Scar pathology

Indexed keywords

COLLAGEN; FIBRILLAR COLLAGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; COLLAGEN FIBER; EPIDERMIS; FEMALE; HISTOLOGY; HUMAN; HYALINE DEGENERATION; HYPERTROPHIC SCAR; INFLAMMATION; INFLAMMATORY CELL; KELOID; MALE; MICROVASCULATURE; PRIORITY JOURNAL; SKIN FIBROBLAST; SKIN NODULE; YOUNG ADULT; CASE REPORT; DIFFERENTIAL DIAGNOSIS; FIBROBLAST; INJURIES; PATHOLOGY; SKIN; SKIN DISEASE; WOUND HEALING;

ADULT; CICATRIX, HYPERTROPHIC; COLLAGEN; DIAGNOSIS, DIFFERENTIAL; FEMALE; FIBRILLAR COLLAGENS; FIBROBLASTS; HUMANS; INFLAMMATION; KELOID; MALE; MICROVESSELS; SKIN; SKIN DISEASES; WOUND HEALING; YOUNG ADULT;

EID: 84924745079     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/j.1742-481X.2012.01118.x     Document Type: Article

References (15)

1. Bran GM, Goessler UR, Hormann K, Riedel F, Sadick H. Keloids: current concepts of pathogenesis (review). Int J Mol Med 2009;24: 283-93.
2. Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, Holmes JW, Longaker MT, Yee H, Gurtner GC. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 2007;21:3250-61.
3. Lee JY, Yang CC, Chao SC, Wong TW. Histopathological differential diagnosis of keloid and hypertrophic scar. Am J Dermatopathol 2004;26:379-84.
4. Ehrlich HP, Desmoulière A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G. Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 1994;145:105-13.
5. Clark JA, Turner ML, Howard L, Stanescu H, Kleta R, Kopp JB. Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity. BMC Dermatol 2009;9:8.
6. Kischer CW. The microvessels in hypertrophic scars, keloids and related lesions: a review. J Submicrosc Cytol Pathol 1992;24:281-96.
7. Appleton I, Brown NJ, Willoughby DA. Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids. Am J Pathol 1996;149:1441-7.
8. Boyce DE, Ciampolini J, Ruge F, Murison MS, Harding KG. Inflammatory-cell subpopulations in keloid scars. Br J Plast Surg 2001;54:511-6.
9. Martin CW, Muir IF. The role of lymphocytes in wound healing. Br J Plast Surg 1990;43:655-62.
10. Hertz MI, Henke CA, Nakhleh RE, Harmon KR, Marinelli WA, Fox JM, Kubo SH, Shumway SJ, Bolman RM 3rd, Bitterman PB. Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci U S A 1992;89:10385-9.
11. Ogawa R, Okai K, Tokumura F, Mori K, Ohmori Y, Huang C, Hyakusoku H, Akaishi S. The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair Regen. 2012;20: 149-57.
12. Ogawa R. Mechanobiology of scarring. Wound Repair Regen. 2011; 19(Suppl 1): s2-s9.
13. Le AD, Zhang Q, Wu Y, Messadi DV, Akhondzadeh A, Nguyen AL, Aghaloo TL, Kelly AP, Bertolami CN. Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. Cells Tissues Organs 2004;176:87-94.
14. Akaishi S, Ogawa R, Hyakusoku H. Keloid and hypertrophic scar: neurogenic inflammation hypotheses. Med Hypotheses 2008;71:32-8.
15. Louw L. Keloids in rural black South Africans. Part 1: general overview and essential fatty acid hypotheses for keloid formation and prevention. Prostaglandins Leukot Essent Fatty Acids 2000;63: 237-45.