Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

ACS Medicinal Chemistry Letters

Volumn 6, Issue 3, 2015, Pages 344-348

  Zou, Bin ^a   Chan, Wai Ling ^a   Ding, Mei ^a   Leong, Seh Yong ^a   Nilar, Shahul ^a   Seah, Peck Gee ^a   Liu, Wei ^a   Karuna, Ratna ^a   Blasco, Francesca ^a   Yip, Andy ^a   Chao, Alex ^a   Susila, Agatha ^a   Dong, Hongping ^a   Wang, Qing Yin ^a   Xu, Hao Ying ^a   Chan, Katherine ^a   Wan, Kah Fei ^a   Gu, Feng ^a   Diagana, Thierry T ^a   Wagner, Trixie ^b   Dix, Ina ^b   Shi, Pei Yong ^a   Smith, Paul W ^a   more..

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Dengue virus (DENV); lead optimization; spiropyrazolopyridones; structure activity relationship

Indexed keywords

ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 4B; PYRIDONE DERIVATIVE; SPIROPYRAZOLOPYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DENGUE; DENGUE VIRUS; DENGUE VIRUS 2; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

DENGUE VIRUS;

EID: 84924719200     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500521r     Document Type: Article

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