Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma

Experimental and Molecular Pathology

Volumn 98, Issue 2, 2015, Pages 260-267

  Zeng, Yuan Feng ^a,c   Xiao, Yi Sheng ^b   Lu, Ming Zhi ^a   Luo, Xiao Jiang ^a   Hu, Guo Zhu ^a   Deng, Ke Yu ^c   Wu, Xiao Mu ^a   Xin, Hong Bo ^c  

^a Jiangxi Provincial People's Hospital   (China)

^b Jiangxi University of Chinese Traditional Medicine   (China)

^c NANCHANG UNIVERSITY   (China)

Author keywords

Colorectal carcinoma (CRC); Formin like 3 (FMNL3); Metastasis; Prognosis

Indexed keywords

CELL PROTEIN; FORMIN LIKE 3 PROTEIN; UNCLASSIFIED DRUG; FMNL3 PROTEIN, HUMAN; PROTEIN; SMALL INTERFERING RNA; TUMOR MARKER;

ADULT; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELL DIFFERENTIATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; FMNL3 GENE; GENDER; GENE; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL ADHESION; CELL TRANSFORMATION; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; HT 29 CELL LINE; METABOLISM; MIDDLE AGED; MORTALITY; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; SURVIVAL RATE; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CELL ADHESION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84924714678     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2015.03.008     Document Type: Article

References (33)

1. Coppede F., et al. Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer. World J. Gastroenterol. 2014, 20:943-956. 10.3748/wjg.v20.i4.943.
2. Eisenmann K.M., et al. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. Curr. Biol. 2007, 17:579-591. 10.1016/j.cub.2007.03.024.
3. Faix J., Grosse R. Staying in shape with formins. Dev. Cell 2006, 10:693-706. 10.1016/j.devcel.2006.05.001.
4. Fidler I.J. Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis. Cancer Metastasis Rev. 1991, 10:229-243. 10.1038/onc.2009.515.
5. Gauvin T.J., et al. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. Mol. Biol. Cell 2015, 26:467-477. 10.1091/mbc.E14-07-1247.
6. Goode B.L., Eck M.J. Mechanism and function of formins in the control of actin assembly. Annu. Rev. Biochem. 2007, 76:593-627. 10.1146/annurev.biochem.75.103004.142647.
7. Guye M.L., et al. Designing liver resections and pushing the envelope with resections for hepatic colorectal metastases. Indian J. Surg. Oncol. 2013, 4:349-355. 10.1146/annurev.biochem.75.103004.142647.
8. Hager M.H., et al. DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol. Med. 2012, 4:743-760. 10.1002/emmm.201200242.
9. Harris E.S., et al. Assembly of filopodia by the formin FRL2 (FMNL3). Cytoskeleton (Hoboken) 2010, 67:755-772. 10.1002/cm.20485.
10. Harrison S., Benziger H. The molecular biology of colorectal carcinoma and its implications: a review. Surgeon 2011, 9:200-210. 10.1016/j.surge.2011.01.011.
11. Hetheridge C., et al. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. J. Cell Sci. 2012, 125:1420-1428. 10.1242/jcs.091066.
12. Iiizumi M., et al. RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res. 2008, 68:7613-7620. 10.1158/0008-5472.CAN-07-6700.
13. Katoh M., Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003, 22:1161-1168. 10.3892/ijo.22.5.1161.
14. Kitzing T.M., et al. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 2007, 21:1478-1483. 10.1101/gad.424807.
15. Kitzing T.M., et al. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene 2010, 29:2441-2448. 10.1038/onc.2009.515.
16. Li Y., et al. FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition. Mol. Cancer Res. 2010, 8:1579-1590. 10.1158/1541-7786.MCR-10-0081.
17. Lin Y.N., et al. Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells. Int. J. Cancer 2014, 134:1571-1582. 10.1002/ijc.28486.
18. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262.
19. Lizarraga F., et al. Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res. 2009, 69:2792-2800. 10.1158/0008-5472.CAN-08-3709.
20. Lynch J., et al. Metastasis suppressor microRNA-335 targets the formin family of actin nucleators. PLoS One 2013, 8:e78428. 10.1371/journal.pone.0078428.
21. Manfredi S., et al. Epidemiology and management of liver metastases from colorectal cancer. Ann. Surg. 2006, 244:254-259. 10.1097/01.sla.0000217629.94941.cf.
22. Martin-Rufian M., et al. Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display. Cancer Biol. Ther. 2006, 5:54-58. 10.4161/cbt.5.1.2238.
23. Millikan K.W., et al. Invasive therapy of metastatic colorectal cancer to the liver. Surg. Clin. North Am. 1997, 77:27-48. 10.1016/S0039-6109(05)70531-4.
24. Moriya K., et al. Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3. Biosci. Biotechnol. Biochem. 2012, 76:1201-1209. 10.1271/bbb.120069.
25. Sahai E. Illuminating the metastatic process. Nat. Rev. Cancer 2007, 7:737-749. 10.1038/nrc2229.
26. Shen L., et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:18654-18659. 10.1073/pnas.0704652104.
27. Soumaoro L.T., et al. Cyclooxygenase-2 expression: a significant prognostic predictor for patients with colorectal cancer. Clin. Cancer Res. 2004, 10:8465-8471. 10.1158/1078-0432.CCR-04-0653.
28. Thurston S.F., et al. The ability to induce microtubule acetylation is a general feature of formin proteins. PLoS One 2012, 7:e48041. 10.1371/journal.pone.0048041.
29. Vega F.M., et al. RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J. Cell Biol. 2011, 193:655-665. 10.1083/jcb.201011038.
30. Wodarz A., Nathke I. Cell polarity in development and cancer. Nat. Cell Biol. 2007, 9:1016-1024. 10.1038/ncb433.
31. Yamamoto H., et al. Expression levels as a novel prognostic marker for colorectal cancer. Oncol. Lett. 2014, 8:2305-2309. 10.3892/ol.2014.2460.
32. Zhu X.L., et al. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. Int. J. Colorectal Dis. 2008, 23:1041-1047. 10.1007/s00384-008-0520-2.
33. Zhu X.L., et al. FMNL2 is a positive regulator of cell motility and metastasis in colorectal carcinoma. J. Pathol. 2011, 224:377-388. 10.1002/path.2871.