The luteinizing hormone beta-subunit exon 3 (Gly102Ser) gene mutation and ovarian responses to controlled ovarian hyperstimulation

Iranian Journal of Reproductive Medicine

Volumn 12, Issue 10, 2014, Pages 667-672

  Davar, Robab ^a   Tabibnejad, Nasim ^a   Kalantar, Seyed Mehdi ^a   Sheikhha, Mohammad Hasan ^a  

^a Shahid Sdoughi Hospital   (Iran)

Author keywords

LH gene; Ovulation induction; Single nucleotide polymorphisms

Indexed keywords

ADENINE; BUSERELIN; CHORIONIC GONADOTROPIN; GUANINE; LUTEINIZING HORMONE BETA SUBUNIT; PROGESTERONE; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CLINICAL PROTOCOL; CONTROLLED OVARIAN HYPERSTIMULATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC ACCURACY; DNA POLYMORPHISM; DRUG DOSE REDUCTION; EMBRYO; EXON; FEMALE; FEMALE INFERTILITY; FETUS; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; LUTEINIZING HORMONE BETA SUBUNIT EXON 3 GENE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVARY FUNCTION; OVARY HYPERSTIMULATION; POLYMERASE CHAIN REACTION; PREDICTION; PROGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT RESPONSE;

EID: 84924617021     PISSN: 16806433     EISSN: 20082177     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. 64TSociety for Assisted Reproductive Technology64T; 64TAmerican Society for Reproductive Medicine64T. 64TAssisted reproductive technology in the United States: 2001 results generated from the American Society for Reproductive Medicine/ Society for Assisted Reproductive Technology registry.64T Fertil Steril 2007; 87: 1253-1266.
2. Verberg MF, Eijkemans MJ, Macklon NS, Heijnen EM, Baart EB, Hohmann FP, et al. The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis. Hum Reprod Update 2009; 15: 5-12.
3. Yong PY, Brett S, Baird DT, Thong KJ. A prospective randomized clinical trial comparing 150 IU and 225 IU of recombinant follicle-stimulating hormone (Gonal-F*) in a fixed-dose regimen for controlled ovarian stimulation in in vitro fertilization treatment. Fertil Steril 2003; 79: 308-315.
4. Out HJ, Rutherford A, Fleming R, Tay CC, Trew G, Ledger W, et al. A randomized, double-blind, multicentre clinical trial comparing starting doses of 150 and 200 IU of recombinant FSH in women treated with the GnRH antagonist ganirelix for assisted reproduction. Hum Reprod 2004; 19: 90-95.
5. Themmen AP. An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphisms. Reproduction 2005; 130: 263-274.
6. Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to folliclestimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab 2000; 85: 3365-3369.
7. Jun JK, Yoon JS, Ku S, Choi YM, Hwang KR, Park SY, et al. Follicle stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET. J Hum Genet 2006; 51: 665-670.
8. Alviggi C, Clarizia R, Pettersson K, Mollo A, Humaidan P, Strina I, et al. Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism. Reprod Biomed Online 2009; 18: 9-14.
9. 9. 64THuhtaniemi I64T, 64TAlevizaki M64T. Gonadotrophin resistance. TBest Pract Res Clin Endocrinol Metab 64T2006; 20: 561576.
10. 64THuhtaniemi IT64T, 64Themmen AP64T. Mutations in human gonadotropin and gonadotropin-receptor genes. 64TEndocrine64T 2005; 26: 207-217.
11. Loutradis D, Patsoula E, Minas V, Koussidis GA, Antsaklis A, Michalas S, et al. FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSIET programs. J Assist Reprod Genet 2006; 23: 177184.
12. Achrekar SK, Modi DN, Desai SK, Mangoli VS, Mangoli RV, Mahale SD. Poor ovarian response to gonadotrophin stimulation is associated with FSH receptor polymorphism. Reprod Biomed Online 2009; 18: 509-515.
13. Sheikhha MH, Eftekhar M, Kalantar SM. 64TInvestigating the association between polymorphism of folliclestimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation.64T J Hum Reprod Sci 2011; 4: 86-90.
14. Piersma D, Verhoef-Post M, Look MP, Uitterlinden AG, Pols HAP, Berns EMJJ, et al. Polymorphic variations in exon 10 of the luteinizing hormone receptor: Functional consequences and associations with breast cancer. Mol Cell Endocrinol 2007; 276: 63-70.
15. Simoni M, Tuttelmann F, Michel C, Bockenfeld Y, Nieschlag E, Gromoll J. Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility. Pharmacogenet Genomics 2008; 18: 193-200.
16. 64TLiao WX64T, 64TRoy AC64T, 64TChan C64T, 64TArulkumaran S64T, 64TRatnam SS64T. A new molecular variant of luteinizing hormone associated with female infertility. 64TFertil Steril64T 1998; 69: 102-106.
17. Twigt JM, Hammiche F, Sinclair KD, Beckers NG, Visser JA, Lindemans J, et al. Preconception folic Acid use modulates estradiol and follicular responses to ovarian stimulation. J Clin Endocrinol Metab 2011; 96: E322-E329.
18. Kim NK, Nam YS, Ko JJ, Chung HM, Chung KW, Cha KY: The luteinizing hormone b-subunit exon 3 (Gly102Ser) gene mutation is rare in Korean women with endometriosis and polycystic ovary syndrome. Fertil Steril 2001; 75: 1238-1239.
19. Van Voorhis BJ. Outcomes from assisted reproductive technology. Obstet Gynecol 2006; 107: 183-200.
20. Fauser BC, Diedrich K, Devroey P. Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation. Hum Reprod Update 2008; 14: 1-14.
21. Themmen AP., Huhtaniemi IT. Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 2000; 21: 551-583.
22. Richter-Unruh A, Martens JWM, Verhoef-Post M, Wessels K, Kors WA, Sinnecker GHG, et al. Leydig cell hypoplasia: cases with new mutations, new polymorphism and cases without mutations in the luteinizing hormone receptor gene. Clin Endocrinol (Oxf) 2002; 56: 103-112.
23. Altmäe S, Hovatta O, Stavreus-Evers A, Salumets A. Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Hum Reprod Update 2011; 17: 813-828.
24. Christofolini DM, Vilarino FL, Mafra FA, André GM, Bianco B, Barbosa CP. Combination of polymorphisms in luteinizing hormone β, estrogen receptor β and progesterone receptor and susceptibility to infertility and endometriosis. 64TEur J Obstet Gynecol Reprod Biol64T 2011; 158: 260264.
25. 64THashad D, Mohamed N, Hashad MM. Luteinising hormone β-subunit gene Gly102Ser variant and oxidative stress biomarkers in Egyptian infertile males. Andrologia 2012; 44 (Suppl.): 484-489.
26. Kerkelä E, Skottman H, Friden B, Bjuresten K, Kere J, Hovatta O. Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome. Fertil Steril 2007; 87: 603-606.
27. Maman E, Yung T, Kedem A, Yerushalmi GM, Konopnicki S, Cohen B, et al. High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization. 64TFertil Steril64T 2012; 97: 592598.
28. Bentov Y, Kenigsberg S, Casper R. A novel luteinizing hormone/chorionic gonadotropin receptor mutation associated with amenorrhea, low oocyte yield, and recurrent pregnancy loss. TFertil Steril 2012; 97: 1165-1168.
29. 29. Papamentzelopoulou M, Mavrogianni D, Partsinevelos GA, Marinopoulos S, Dinopoulou V, Theofanakis C, et al. LH receptor gene expression in cumulus cells in women entering an ART program. J Assist Reprod Genet2012; 29: 409416.
30. Mafra FA, Bianco B, Christofolini DM, Souza AM, Zulli K, Barbosa CP. Luteinizing hormone betasubunit gene (LHbeta) polymorphism in infertility and endometriosis-associated infertility. Eur J Obstet Gynecol Reprod Biol 2010; 151: 66-69.
31. Ramanujam LN, Liao WX, Roy AC, Loganath A, Goh HH, Ng SC: Association of molecular variants of luteinizing hormone with menstrual disorders. Clin Endocrinol (Oxf) 1999, 51: 243-246.
32. Liu N, Ma Y, Wang S, Zhang X, Zhang Q, Zhang X, et al. Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome. Reprod Biol Endocrinol 2012, 10: 36.