Combination effect of pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia

Iranian Journal of Reproductive Medicine

Volumn 12, Issue 12, 2014, Pages 817-824

  Mehni, Najme Moslemi ^a   Ketabchi, Ali Asghar ^b   Hosseini, Ebrahim ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Idiopathic; L carnitine; Male infertility; Oligoasthenoteratozoospermia; Pentoxifylline

Indexed keywords

CARNITINE; PENTOXIFYLLINE; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; HUMAN; IDIOPATHIC DISEASE; IDIOPATHIC OLIGOASTHENOTERATOZOOSPERMIA; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; RANDOMIZED CONTROLLED TRIAL; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

EID: 84924598824     PISSN: 16806433     EISSN: 20082177     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Singh R, Kaleem AM, Narayana SS, Mahdi AA. A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress. Indian J Hum Genet 2012; 18: 359-362.
2. Sharlip ID JJ, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, et al. Best practice policies for male infertility. Fertil Steril 2002; 77: 873-882.
3. Siddiq FM SM. A new look at the medical management of infertility. Urol Clin North Am 2002; 29: 949-963.
4. Kumar R GG, Gupta NP. Drug therapy for idiopathic male infertility. J Urol 2006; 176: 1307-1312.
5. Bonanomi M LG, Silvestrini B. Male fertility: core chemical structure in pharmacological research. Contraception 2002; 65: 317-320.
6. Turhan N, Pekel A, Ayrim A, Bayrak O. ICSI outcome in severely ligoasthenozoospermic patients and its relationship to prewash progressive sperm motility. Turk J Med Sci 2011; 41: 995-9995.
7. Rhemrev JPT LJ, McDonnell J, Schoemaker J, Vermaiden JPW. The postwash total progressively motile sperm cell count is a reliable predictor of total fertilization failure during in vitro treatment. Fertil Steril 2001; 76: 884-891.
8. Devroey PVM, Nagy P, Van Steirteghem A. Do we treat the male or his gamete? Hum Reprod 1998; 13: 178-185.
9. Kumar R, Saxena V, Shamsi MB, Venkatesh S, Dada R. Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia: A double blind randomized placebo-controlled trial. Indian J Urol 2011; 27: 357-362.
10. Terriou P, Hans E, Giorgetti C, Spach JL, Salzmann J, Urrutia V, et al. Immotile Epididymal and Testicular Spermatozoa and Allows Normal Fertilization, Pregnancy, and Birth After Intracytoplasmic Sperm Injection. J Assist Reprod Genet 2000; 17: 194-199.
11. Archer SL, William E. Enhancement of Sperm Motility Using Pentoxifylline and Platelet-Activating Factor. Spermatogenesis. Methods Mol Biol 2013; 927: 241-245.
12. Yovich JM EW, Cummins JM, Yovich JL. Influence of pentoxifylline in severe male factor infertility. Fertil Steril 1990; 53: 715.
13. Jeulin C LL. Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update 1996; 2: 87-102.
14. Tesarik J TA, Testart J. Effect of pentoxifylline on sperm movement characteristics in normozoospermic and asthenozwspermic specimens. Hum Reprod 1992; 7: 1257.
15. Hassanzadeh KYP, Emdady V, Maden SK. Effect of oral pentoxifylline on semen parameters in oligoastheno sperm patients. J Ardabil Univ Med Sci 2010; 10: 217-222.
16. Frenkel RA MGJ. Carnitine biosyntesis, metabolism and function. Academic Press; 1984: 271-284.
17. Peluso GNR, Reda E, Benatti P, Barbarisi A, Calvani M. Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system. J Cell Physiol 2000; 182: 339-350.
18. Lenzi ALF, Sgrò P, Salacone P, Caponnecchia L, Dondero F. Use of carnitine therapy in selected cases of male factor infertility: a double blind cross over trial. Fertil Steril 2003; 79: 292-300.
19. Gattuccio FDRA, Latteri MA. Varicocele. Cofese Editore 2000: 205-210.
20. Menchini Fabris GF CD, Izzo PL, Olivieri L, Bartonelli M. Free L-carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril 1984; 42: 263-267.
21. Bornman MS dTD, Otto B, Muller Il, Hurter P, du Plessis DJ. Seminal carnitine, epididymal function and spermatozoal motility. S Afr Med J 1989; 75: 20-21.
22. Vitali G PR, Melotti C. Carnitine supplementation in human idiopathic asthenospermia: clinical results. Drugs Exptl Clin Res 1995; 4: 157-159.
23. Lenzi A SP, Salacone P, Paoli D, Gilio B, Lombardo F, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1578-1584.
24. Khademi A, Alleyassin A, Agha-Hosseini M, Akbari Hamed E, Saeidi Saeidabadi H, Pooyan O. The effect of L-carnitine on sperm parameters in patients candidate for Intracytoplasmic Sperm Injection. Iran J Reprod Med 2004; 2: 65-69.
25. Bongso TA NS, Mok H, Lim MN, Teo HI, Wong PC. The influence of sperm motility on human in vitro fertilization. Arch Androl 1989; 22: 185-190.
26. Agarwal A, Lucky H. Sekhon. Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified? Indian J Urol 2011; 27: 74-85.
27. Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, et al. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism 2010; 59: 1190-1199.
28. Al-Dujaily SS, Al-Nakash AR, Al-Biaty SA. Effect of pentoxifylline on the outcome of artificial inseminations.Iraqi post graduate. Med J 2007; 5: 377-383.
29. Sato M, Ishikawa A. Room temperature storage of mouse epididymal spermatozoa: exploration of factors affecting sperm survival. Theriogenology 2004; 61: 1455-1469.
30. Safarinejad MR. Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study. Int Urol Nephrol 2011; 43: 315-328.
31. Stanic P, Sonicki Z, Suchanek E. Effect of pentoxifylline on motility and membrane integrity of cryopreservation human spermatozoa. Int J Androl 2002; 25: 186-190.
32. Costa M, Canale D, Filicori M, D’Iddio S, Lenzi A: LCarnitine in idiopathic asthenozoospermia: A multicenter study. Italian Study Group on Carnitine and Male infertility. Andrologia 1994; 26: 155-159.
33. Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L,Dondero F, Gandini L: Use of carnitine therapy in selected cases of male factor infertility: A double-blind crossover trial. Fertil Steril 2003; 79: 292-300.
34. Vicari E, Calogero AE: Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Hum Reprod 2001; 16: 2338-2342.
35. Yasuo Kudoh, Shinya Aoyama, Takaaki Torii, Qijie Chen, Daigo Nagahara, Hiromi Sakata, and Akihiko Nozawa. The Effects of Oral L-Carnitine Supplementation on Physical Capacity and Lipid Metabolism in Chronic Hemodialysis Patients. Nephron Extra 2014; 4: 33-41.
36. Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic asthenospermia: Clinical results. Drug Exp Clin Res 1995; 21: 157-159.
37. Moncada ML, Vicari E, Cimino C, Calogero AE, Mongioi A, D’Agata R. Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Eur Fertil 1992; 23: 221-224.
38. Lewin LM, Beer R, Lunenfeld B: Epididymis and seminal vesicle as sources of carnitine in human seminal fluid: The clinical significance of the carnitine concentration in human seminal fluid. Fertil Steril 1976; 27: 9-13.
39. Nawras N. Shams Alddin, Saad S. Al-Dujaily, Yahya K. Al-Sultani.In vitro sperm activation with pentoxifylline and L-carnitine for infertile men semen using layering and sedimentation techniques. Iraq J Embryos Infertil Res 2013; 3: 32-37.
40. Bonanomi M, Lucente G, Silvestrini B. Male fertility: core chemical structure in pharmacological research. Contraception 2002; 65: 317-320.
41. Peivandi S, Karimpour A, Moslemizadeh N. Effects of L-carnitine on Infertie Men’s Spermogram, a Randomized Clinical Trial. J Reprod Infertil 2010; 10: 331.
42. Aliabadi E, Karimi F, Rasti M, Akmali M, Esmaeilpour T. Effects of L-carnitine and Pentoxifylline on the Activity of Lactate Dehydrogenase C4 isozyme and Motility of Testicular Spermatozoa in Mice. J Reprod Infertil 2013; 14: 56-61.
43. Ozkan L, Yardimoglu M, Ozkurkcugil C, Costur P, Yilmaz H, Isken T. Protective effects of pentoxifylline on the seminiferous tubules morphology in smoking rats. Research Web Pub 2013; 1: 1-6.
44. Homan GF, Davies M, Norman R. “The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review.” Hum Reprod Update 2007; 13: 209-223.