Warfarin use, mortality, bleeding and stroke in haemodialysis patients with atrial fibrillation

Nephrology Dialysis Transplantation

Volumn 30, Issue 3, 2015, Pages 491-498

  Genovesi, Simonetta ^a,b   Rossi, Emanuela ^a   Gallieni, Maurizio ^c   Stella, Andrea ^a,b   Badiali, Fabio ^d   Conte, Ferruccio ^e   Pasquali, Sonia ^f   Bertoli, Silvio ^g   Ondei, Patrizia ^h   Bonforte, Giuseppe ⁱ   Pozzi, Claudio ^j   Rebora, Paola ^a   Valsecchi, Maria Grazia ^a   Santoro, Antonio ^k  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c SAN CARLO BORROMEO HOSPITAL   (Italy)

^d Infermi Hospital   (Italy)

^e Nephrology Unit S Uboldo Hospital   (Italy)

^f S MARIA NUOVA HOSPITAL   (Italy)

^g IRCCS MULTIMEDICA   (Italy)

^h OSPEDALI RIUNITI   (Italy)

ⁱ SANT ANNA HOSPITAL   (Italy)

^j Bassini Hospital   (Italy)

^k UNIVERSITY OF BOLOGNA   (Italy)

more..

Author keywords

atrial fibrillation; bleeding; haemodialysis; mortality; oral anticoagulation therapy; stroke

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; LOW MOLECULAR WEIGHT HEPARIN; TICLOPIDINE; WARFARIN; ANTICOAGULANT AGENT;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE ASSESSMENT; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; CHA2DS2VASC SCORE; FEMALE; FOLLOW UP; HASBLED SCORE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEMODIALYSIS; HUMAN; ITALY; LOW RISK PATIENT; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOEMBOLISM; ATRIAL FIBRILLATION; EPIDEMIOLOGY; HEMORRHAGE; INCIDENCE; RENAL REPLACEMENT THERAPY; RISK FACTOR; STROKE; SURVIVAL RATE;

AGED; ANTICOAGULANTS; ATRIAL FIBRILLATION; FEMALE; HEMORRHAGE; HUMANS; INCIDENCE; ITALY; MALE; PROSPECTIVE STUDIES; RENAL DIALYSIS; RISK FACTORS; STROKE; SURVIVAL RATE; WARFARIN;

EID: 84924418159     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu334     Document Type: Article

References (27)

1. Fabbian F, Catalano C, Lambertini D et al. Clinical characteristics associated to atrial fibrillation in chronic hemodialysis patients. Clin Nephrol 2000; 54: 234-239
2. Vazquez E, Sanchez-Perales C, Borrego F et al. Influence of atrial fibrillation on the morbido-mortality of patients on hemodialysis. Am Heart J 2000; 140: 886-890
3. Genovesi S, Pogliani D, Faini A et al. Prevalence of atrial fibrillation and associated factors in a population of long-term hemodialysis patients. Am J Kidney Dis 2005; 46: 897-902
4. WinkelmayerWC, Patrick AR, Liu JMet al. The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol 2011; 22: 349-357
5. Lip GY. Stroke in atrial fibrillation: epidemiology and thromboprophylaxis. J Thromb Haemost 2011; 9:344-351
6. Vazquez E, Sanchez-Perales C, Garcia-Garcia F et al. Atrial fibrillation in incident dialysis patients. Kidney Int 2009; 76: 324-330
7. Sanchez-Perales C, Vazquez E, Garcia-Cortes MJ. Ischaemic stroke in incident dialysis patients. Nephrol Dial Transplant 2010; 25: 3343-3348
8. Seliger SL, Gillen DL, Longstreth WT et al. Elevated risk of stroke among patients with end-stage renal disease. Kidney Int 2003; 64: 603-609
9. Camm AJ, Kirchhof P, Lip GY et al. ESC Committee for Practice Guidelines, Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 2010; 12: 1360-1420
10. Chan KE, Lazarus JM, Thadhani R et al. Warfarin use associates with increased risk for stroke in hemodialysis patients with atrial fibrillation. J Am Soc Nephrol 2009; 20: 2223-2233
11. Wizemann V, Tong L, Statayathum S et al. Atrial fibrillation in hemodialysis patients: clinical features and associations with anticoagulant therapy. Kidney Int 2010; 77: 1098-1106
12. Shah M, Tsadok MA, Jackevicius CA et al. Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis. Circulation 2014; 129:1196-1203
13. Olesen JB, Lip GYH, Kamper AL et al. Stroke and bleeding in atrial fibrillation with chronic kidney disease. N Engl J Med 2012; 367: 625-635
14. Sood MM, Larkina M, Thumma JR et al. Major bleeding events and risk stratification of antithrombotic agents in hemodialysis: results from the DOPPS. Kidney Int 2013, 84, 600-608
15. Rosendaal FR, Cannegieter SC, van der Meer FJM et al. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 1993; 69: 236-239
16. Ibrahim S, Jespersen J, Poller L. On behalf of the European Action on Anticoagulation. The clinical evaluation of international normalized ratio variability and control in conventional oral anticoagulant administration by use of the variance growth rate. J Thromb Haemost 2013; 11: 1540-1546
17. Camm AJ, Lip GYH, De Caterina R et al. An update of the 2010 ESC Guidelines for the management of atrial fibrillation developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33: 2719-2747
18. Chan KE, Lazarus JM, Thadhani R et al. Anticoagulant and antiplatelet usage associates with mortality among hemodialysis patients. J Am Soc Nephrol 2009 ; 20: 872-881
19. Carrero JJ, Evans M, Szummer K et al. Warfarin, kidney dysfunction, and outcomes following acute myocardial infarction in patients with atrial fibrillation. JAMA 2014; 311: 919-928
20. Genovesi S, Vincenti A, Rossi E et al. Atrial fibrillation and morbidity and mortality in a cohort of long-term hemodialysis patients. Am J Kidney Dis 2008; 2: 255-262
21. Marijon E, Le Heuzey JY, Connolly S et al. for the RE-LY Investigators. Causes of death and influencing factors in patients with atrial fibrillation a competing-risk analysis from the Randomized Evaluation of Long-Term Anticoagulant Therapy Study. Circulation 2013; 128: 2192-2201
22. Andersson1 T, Magnuson A, Bryngelsson IL et al. All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study. Eur Heart J 2013; 34: 1061-1067
23. Elliott MJ, Zimmerman D, Holden RM. Warfarin anticoagulation in hemodialysis patient: a systemic review of bleeding rates. Am J Kidney Dis 2007; 50: 433-440
24. Winkelmayer WC, Liu J, Setoguchi S et al. Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation. Clin J Am Soc Nephrol 2011; 6: 2662-2668
25. Genovesi S, Rossi E, Pogliani D et al. The nephrologist's anticoagulation treatment patterns/regimens in chronic hemodialysis patients with atrial fibrillation. J Nephrol 2014; 27: 187-192
26. Friedman PA, Holmes DR. Non-surgical left atrial appendage closure for stroke prevention in atrial fibrillation. J Cardiovasc Electrophysiol 2011; 22:1184-1191
27. Piccini JP, Stevens SR, Chang Y et al. Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. Circulation 2013; 127: 224-232