Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men

BMJ Open

Volumn 4, Issue , 2014, Pages

  Jensen, Tina Kold ^a,b   Gottschau, Mads ^a   Madsen, Jens Otto Broby ^a   Andersson, Anne Maria ^b   Lassen, Tina Harmer ^b   Skakkebæk, Niels E ^b   Swan, Shanna H ^c   Priskorn, Lærke ^a   Juul, Anders ^b   Jørgensen, Niels ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ESTRADIOL; FOLLITROPIN; HORMONE; INHIBIN B; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; INHIBIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BINGE DRINKING; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DANISH CITIZEN; ESTRADIOL BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEDICAL EXAMINATION; MILITARY SERVICE; NORMAL HUMAN; SPERM QUALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; ADOLESCENT; ADVERSE EFFECTS; ALCOHOLISM; BLOOD; COMPLICATION; DENMARK; DRINKING BEHAVIOR; DRUG EFFECTS; EPIDEMIOLOGY; SEMEN ANALYSIS; SPERM; YOUNG ADULT;

ADOLESCENT; ADULT; ALCOHOL DRINKING; ALCOHOLISM; BINGE DRINKING; CROSS-SECTIONAL STUDIES; DENMARK; ESTRADIOL; FOLLICLE STIMULATING HORMONE; HUMANS; INHIBINS; LUTEINIZING HORMONE; MALE; SEMEN; SEMEN ANALYSIS; SEX HORMONE-BINDING GLOBULIN; SPERM COUNT; TESTOSTERONE; YOUNG ADULT;

EID: 84924416299     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2014-005462     Document Type: Article

References (46)

1. Eurobarometer. EU citizens' attitudes towards alcohol. Secondary EU citizens' attitudes towards alcohol 2010. http://ec.europa.eu/health/alcohol/docs/ebs-331-en.pdf
2. Simons-Morton B, Pickett W, Boyce W, et al. Cross-national comparison of adolescent drinking and cannabis use in the United States, Canada, and the Netherlands. Int J Drug Policy 2010;21:64-9.
3. Saleem TS, Basha SD. Red wine: a drink to your heart. J Cardiovasc Dis Res 2010;1:171-6.
4. Farke W, Anderson P. Binge drinking in Europe. Adicciones 2007;19:333-9.
5. Dawson DA, Li TK, Grant BF. A prospective study of risk drinking: at risk for what? Drug Alcohol Depend 2008;95:62-72.
6. Muthusami KR, Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril 2005;84:919-24.
7. Martini AC, Molina RI, Estofan D, et al. Effects of alcohol and cigarette consumption on human seminal quality. Fertil Steril 2004;82:374-7.
8. Gaur DS, Talekar MS, Pathak VP. Alcohol intake and cigarette smoking: impact of two major lifestyle factors on male fertility. Indian J Pathol Microbiol 2010;53:35-40.
9. Stutz G, Zamudio J, Santillan ME, et al. The effect of alcohol, tobacco, and aspirin consumption on seminal quality among healthy young men. Arch Environ Health 2004;59:548-52.
10. Chia SE, Tay SK, Lim ST. What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. Hum Reprod 1998;13:3394-8.
11. Dunphy BC, Barratt CL, Cooke ID. Male alcohol consumption and fecundity in couples attending an infertility clinic. Andrologia 1991;23:219-21.
12. Kunzle R, Mueller MD, Hanggi W, et al. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril 2003;79:287-91.
13. Lopez Teijon M, Garcia F, Serra O, et al. Semen quality in a population of volunteers from the province of Barcelona. Reprod Biomed Online 2007;15:434-44.
14. Marshburn PB, Sloan CS, Hammond MG. Semen quality and association with coffee drinking, cigarette smoking, and ethanol consumption. Fertil Steril 1989;52:162-5.
15. Oldereid NB, Rui H, Purvis K. Life styles of men in barren couples and their relationship to sperm quality. Int J Fertil 1992;37:343-9.
16. Hansen ML, Thulstrup AM, Bonde JP, et al. Does last week's alcohol intake affect semen quality or reproductive hormones? A cross-sectional study among healthy young Danish men. Reprod Toxicol 2012;34:457-62.
17. Povey AC, Clyma JA, McNamee R, et al. Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study. Hum Reprod 2012;27:2799-806.
18. Li Y, Lin H, Ma M, et al. Semen quality of 1346 healthy men, results from the Chongqing area of southwest China. Hum Reprod 2009;24:459-69.
19. Jensen TK, Swan S, Jørgensen N, et al. Alcohol and male reproductive health; a cross-sectional study of 8,344 healthy men from Europe and USA. Hum Reprod 2014;29:1801-9.
20. Jørgensen N, Joensen UN, Jensen TK, et al. Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men. BMJ Open 2012;2:pii:e000990.
21. Jensen TK, Andersson AM, Jorgensen N, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004;82:863-70.
22. Jensen TK, Swan SH, Skakkebaek NE, et al. Caffeine intake and semen quality in a population of 2,554 young Danish men. Am J Epidemiol 2010;171:883-91.
23. Jensen TK, Andersson AM, Skakkebaek NE, et al. Association of sleep disturbances with reduced semen quality: a cross-sectional study among 953 healthy young Danish men. Am J Epidemiol 2013;177:1027-37.
24. Jensen TK, Heitmann BL, Jensen MB, et al. High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population. Am J Clin Nutr 2013;97:411-18.
25. Organisation WH. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th edn. Cambridge: Cambridge University Press, 1999.
26. Jorgensen N, Auger J, Giwercman A, et al. Semen analysis performed by different laboratory teams: an intervariation study. Int J Androl 1997;20:201-8.
27. Menkveld R, Stander FS, Kotze TJ, et al. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod 1990;5:586-92.
28. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-72.
29. Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381-95.
30. Adler ID. Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res 1996;352:169-72.
31. Jensen RB, Vielwerth S, Larsen T, et al. Pituitary-gonadal function in adolescent males born appropriate or small for gestational age with or without intrauterine growth restriction. J Clin Endocrinol Metab 2007;92:1353-7.
32. Anderson RA Jr, Willis BR, Oswald C, et al. Hormonal imbalance and alterations in testicular morphology induced by chronic ingestion of ethanol. Biochem Pharmacol 1980;29:1409-19.
33. Anderson RA Jr, Willis BR, Oswald C, et al. Ethanol-induced male infertility: impairment of spermatozoa. J Pharmacol Exp Ther 1983;225:479-86.
34. Pajarinen J, Karhunen PJ, Savolainen V, et al. Moderate alcohol consumption and disorders of human spermatogenesis. Alcohol Clin Exp Res 1996;20:332-7.
35. Muller M, den Tonkelaar I, Thijssen JH, et al. Endogenous sex hormones in men aged 40-80 years. Eur J Endocrinol 2003;149:583-9.
36. Shiels MS, Rohrmann S, Menke A, et al. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control 2009;20:877-86.
37. Svartberg J, Midtby M, Bonaa KH, et al. The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. Eur J Endocrinol 2003;149:145-52.
38. Tamimi R, Mucci LA, Spanos E, et al. Testosterone and oestradiol in relation to tobacco smoking, body mass index, energy consumption and nutrient intake among adult men. Eur J Cancer Prev 2001;10:275-80.
39. Allen NE, Appleby PN, Davey GK, et al. Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men. Cancer Causes Control 2002;13:353-63.
40. Handa K, Ishii H, Kono S, et al. Behavioral correlates of plasma sex hormones and their relationships with plasma lipids and lipoproteins in Japanese men. Atherosclerosis 1997;130:37-44.
41. Maneesh M, Dutta S, Chakrabarti A, et al. Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males. Indian J Physiol Pharmacol 2006;50:291-6.
42. Jorgensen N, Carlsen E, Nermoen I, et al. East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 2002;17:2199-208.
43. Jorgensen N, Andersen AG, Eustache F, et al. Regional differences in semen quality in Europe. Hum Reprod 2001;16:1012-19.
44. Swan SH, Brazil C, Drobnis EZ, et al. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect 2003;111:414-20.
45. Brink A-L, Kræftens Bekæmpelse og Sundhedsstyrelsen Unges livsstil og dagligdag 2008. MULD-rapport nr. 7. 2008.
46. Health DNBo. Secondary. http://www.sundhedsstyrelsen.dk/Sundhedogforebyggelse/Alkohol.aspx