Altered Ca2+ Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution

PLoS Genetics

Volumn 11, Issue 1, 2015, Pages

  Head, Stewart I ^a   Chan, Stephen ^a   Houweling, Peter J ^b,c   Quinlan, Kate G R ^c,d   Murphy, Robyn ^e   Wagner, Sören ^f,g   Friedrich, Oliver ^g   North, Kathryn N ^b,c,g  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e LA TROBE UNIVERSITY   (Australia)

^f UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^h UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ 3; CALCIUM BINDING PROTEIN; CALSEQUESTRIN; MUSCLE PROTEIN; PROTEIN SERCA1; SARCALUMENIN; UNCLASSIFIED DRUG; ACTININ; ACTN3 PROTEIN, HUMAN; CALCIUM;

ADAPTATION; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; COLD ACCLIMATIZATION; COLD EXPOSURE; CONTROLLED STUDY; ENDURANCE; FATIGUE; GENETIC ASSOCIATION; GENETIC SELECTION; GENETIC VARIABILITY; LOSS OF FUNCTION MUTATION; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NULL ALLELE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; SURVIVAL RATE; THERMOGENESIS; ACCLIMATIZATION; ANIMAL; COLD; DEFICIENCY; EVOLUTION; FAST MUSCLE FIBER; GENETIC POLYMORPHISM; GENETICS; HUMAN; KINETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; MUSCLE DISEASE; PATHOLOGY; WEATHER;

MUS;

ACCLIMATIZATION; ACTININ; ANIMALS; BIOLOGICAL EVOLUTION; CALCIUM; COLD TEMPERATURE; HUMANS; KINETICS; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUSCLE FIBERS, FAST-TWITCH; MUSCLE, SKELETAL; MUSCULAR DISEASES; POLYMORPHISM, GENETIC; SELECTION, GENETIC; WEATHER;

EID: 84924370767     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004862     Document Type: Article

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