Association of luteinizing hormone chorionic gonadotropin receptor gene polymorphism (rs2293275) with polycystic ovarian syndrome

Genetic Testing and Molecular Biomarkers

Volumn 19, Issue 3, 2015, Pages 128-132

  Thathapudi, Sujatha ^a   Kodati, Vijayalakshmi ^a   Erukkambattu, Jayashankar ^b   Addepally, Uma ^c   Qurratulain, Hasan ^a,b  

^a Vasavi Medical and Research Centre   (India)

^b Kamineni Academy of Medical Sciences and Research Center   (India)

^c JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FOLLITROPIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR;

ADULT; AGE; ALLELE; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE COURSE; DNA ISOLATION; DNA POLYMORPHISM; EXON; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INDIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; WAIST HIP RATIO; ADOLESCENT; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LH; YOUNG ADULT;

EID: 84924348216     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2014.0249     Document Type: Article

References (16)

1. Azziz R, Carmina E, Dewailly D, et al. (2006) Position statement: criteria for defining PCOS as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab 91:4237-4245
2. Azziz R, Carmina E, Dewailly D, et al. (2009) The androgen excess and PCOS society criteria for the Polycystic ovarian syndrome: the complete task force report. Fertil Steril 91:456-488
3. Balen AH, Laven JSE, Tan SL, Dewailly D (2003) Ultrasound assessment of Polycystic ovary: international consensus definitions. Hum Reprod Update 9:505-514
4. Capalbo A, Saqnella F, Apa R, et al. (2012) The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2.7-fold increased risk of polycystic ovary syndrome in a Sardinian population. Clin Endocrinol (Oxf) 77:113-119
5. Chen X, Ni R, Mo Y, et al. (2010) Appropriate BMI levels for PCOS patients in Southern China. Hum Reprod 25:1295-1302
6. Chen ZJ, Zhao H, He L, et al. (2011) Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3. Nat Genet 43:55-59
7. Govindan S, Ahamad SN, Vedicherla B, et al. (2007) Association of progesterone receptor gene polymorphism (PROGINS with endometriosis, uterine fibroids and breast cancer. Cancer Biomark 3:73-78
8. Kodati VL, Shetty P, VattamK, et al. (2010) Tumor necrosis factor alpha-C850T polymorphism is significantly associated with endometriosis in Asian Indian women. Fertil Steril 94:453-456
9. Legro RS (1995) The genetics of polycystic ovary syndrome. Am J Med 98 Suppl 1 A:165
10. Liang SJ, Hsu CS, Tzeng CR, et al. (2011) Clinical and Biochemical parameters of Polycystic ovary syndrome between the age of 20 and 40. Hum Reprod 12:3443-3449
11. Movva S, Alluri R, Komandur S, et al. (2007) Relationship of angiotensin-converting gene polymorphism with nephropathy associated with type 2 diabetes mellitus in Asian Indians. J Diabetes Complications 21:237-241
12. Rodriguez S, Gaunt TR, Day IN (2009) Hardy-Weinberg equilibrium testing of biological ascertainment for mendelian randomization studies. Am J Epidemiol 169:505-514
13. Themmen APN (2005) Focus on gonadotropin signalling. An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphisms. Reproduction 130:263-274
14. Urbanek M, Legro RS, Driscoll DA, et al. (1999) Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A 96:8573-8578
15. Valkenburg O, Uitterlinden AG, Piersma D, et al. (2009) Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. Hum Reprod 24:2014-2022
16. Zhao H, Chen ZJ (2013) Genetic association studies in female reproduction: from candidate gene approaches to genomewide mapping. Mol Hum Reprod 19:644-654