Antibiotic treatment of severe exacerbations of chronic obstructive pulmonary disease with procalcitonin: A randomized noninferiority trial

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Verduri, Alessia ^a   Luppi, Fabrizio ^a   D'Amico, Roberto ^a   Balduzzi, Sara ^a   Vicini, Roberto ^a   Liverani, Anna ^b   Ruggieri, Valentina ^a   Plebani, Mario ^b   Barbaro, Maria Pia Foschino ^c   Spanevello, Antonio ^d   Canonica, Giorgio Walter ^e   Papi, Alberto ^f   Fabbri, Leonardo Michele ^a   Beghè, Bianca ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF FOGGIA   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; PROCALCITONIN; THEOPHYLLINE; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CALCITONIN; PROTEIN PRECURSOR;

ADULT; ARTERIAL GAS; ARTICLE; BACTERIAL INFECTION; BLOOD ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; CONTROLLED STUDY; COUGHING; DISEASE CLASSIFICATION; DISEASE EXACERBATION; DYSPNEA; ELECTROCARDIOGRAM; FACIAL NERVE PARALYSIS; FEMALE; FEVER; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HOSPITALIZATION; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; PARALLEL DESIGN; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SPUTUM ANALYSIS; STOMACH PAIN; SYMPTOMATOLOGY; THORAX RADIOGRAPHY; TREATMENT DURATION; TREATMENT OUTCOME; VOMITING; AGED; BACTERIAL INFECTIONS; BLOOD; CLINICAL TRIAL; DRUG ADMINISTRATION; DRUG MONITORING; MICROBIOLOGY; PROSPECTIVE STUDY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT INFECTIONS;

BACTERIA (MICROORGANISMS);

AGED; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BIOMARKERS; CALCITONIN; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; FEMALE; HUMANS; ITALY; MALE; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT INFECTIONS; TREATMENT OUTCOME;

EID: 84924347524     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118241     Document Type: Article

References (33)

1. Donaldson GC, Wedzicha JA (2006) COPD exacerbations. 1: Epidemiology. Thorax 61: 164-168.PMID: 16443707
2. Hurst JR (2011) Exacerbation phenotyping in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 184: 625-626. doi: 10.1164/rccm.201106-1136ED PMID: 21920921
3. White AJ, Gompertz S, Stockley RA (2003) Chronic obstructive pulmonary disease. 6: The aetiology of exacerbations of chronic obstructive pulmonary disease. Thorax 58: 73-80. PMID: 12511727
4. Miravitlles M, Anzueto A (2013) Antibiotics for acute and chronic respiratory infection in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 188: 1052-1057. doi: 10.1164/ rccm.201302-0289PP PMID: 23924286
5. Albert R, Connett J, Bailey W, Casaburi R, Cooper JJ, et al. (2011) Azithromycin for prevention of exacerbations of COPD. N Engl J Med 365: 689-698. doi: 10.1056/NEJMoa1104623 PMID: 21864166
6. Han M, Tayob N, Murray S, Dransfield M, Washko G, et al. (2014) Predictors of chronic obstructive pulmonary disease exacerbation reduction in. Am J Respir Crit Care Med 189: 1503-1508. doi: 10.1164/ rccm.201402-0207OC PMID: 24779680
7. Ray W, Murray K, Hall K, Arbogast P, Stein C (2012) Azithromycin and the risk of cardiovascular death. N Engl J Med 366: 1881-1890. doi: 10.1056/NEJMoa1003833 PMID: 22591294
8. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2014) Available: http://www.goldcopd.org/. Last accessed: 2014April 9.
9. Vollenweider DJ, Jarrett H, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA (2012) Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 12: CD010257. doi: 10.1002/14651858.CD010257 PMID: 23235687
10. Daniels JM, Snijders D, de Graaff CS, Vlaspolder F, Jansen HM, et al. (2010) Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 181: 150-157. doi: 10.1164/rccm.200906-0837OC PMID: 19875685
11. Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, et al. (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106: 196-204. PMID: 3492164
12. Woodhead M (2011) New guidelines for the management of adult lower respiratory tract infections. Eur Respir J 38: 1250-1251. doi: 10.1183/09031936.00105211 PMID: 22130759
13. Blasi F, Bocchino M, Di Marco F, Richeldi L, Aliberti S (2012) The role of biomarkers in low respiratory tract infections. Eur J Intern Med 23: 429-435. doi: 10.1016/j.ejim.2012.05.002 PMID: 22726371
14. Koutsokera A, Stolz D, Loukides S, Kostikas K (2012) Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge. Chest 141: 396-405. doi: 10.1378/chest.11-0495 PMID: 21835899
15. Soler N, Esperatti M, Ewig S, Huerta A, Agusti C, et al. (2012) Sputum purulence-guided antibiotic use in hospitalised patients with exacerbations of COPD. Eur Respir J 40: 1344-1353. doi: 10.1183/ 09031936.00150211 PMID: 22523352
16. Bafadhel M, Clark TW, Reid C, Medina MJ, Batham S, et al. (2011) Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest 139: 1410-1418. doi: 10.1378/chest.10-1747 PMID: 21030489
17. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, et al. (2004) Effect of procalcito-nin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 363: 600-607. PMID: 14987884
18. Christ-Crain M, Stolz D, Bingisser R, Muller C, Miedinger D, et al. (2006) Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med 174: 84-93. PMID: 16603606
19. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, et al. (2009) Effect of procalcitoninbased guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the Pro-HOSP randomized controlled trial. JAMA 302: 1059-1066. doi: 10.1001/jama.2009.1297 PMID: 19738090
20. Stolz D, Christ-Crain M, Bingisser R, Leuppi J, Miedinger D, et al. (2007) Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy. Chest 131: 9-19. PMID: 17218551
21. Christ-Crain M, Muller B (2005) Procalcitonin in bacterial infections-hype, hope, more or less? Swiss Med Wkly 135: 451-460. PMID: 16208582
22. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2005. Available: http://www.goldcopd.org/. Last accessed: 2014April 9.
23. Schuetz P, Briel M, Mueller B (2013) Clinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infections. JAMA 309: 717-718. doi: 10.1001/jama.2013. 697 PMID: 23423417
24. Rodriguez-Roisin R (2000) Toward a consensus definition for COPD exacerbations. Chest 117: 398S-401S. PMID: 10843984
25. Miller MR, Hankinson J, Brusasco V, Burgos F, ATS/ERS Task Force, et al. (2005) Standardization of spirometry. Eur Respir J. Aug; 26(2):319-38 PMID: 16055882
26. Isenberg H (1992) Clinical microbiology procedures handbook. Washington, DC; Blackwell.
27. Baiardini I, Braido F, Fassio O, Tarantini F, Pasquali M, et al. (2005) A new tool to assess and monitor the burden of chronic cough on quality of life: Chronic Cough Impact Questionnaire. Allergy 60: 482-488. PMID: 15727580
28. Brazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, et al. (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 305: 160-164. PMID: 1285753
29. Mahler DA, Tomlinson D, Olmstead EM, Tosteson AN, O'Connor GT (1995) Changes in dyspnea, health status, and lung function in chronic airway disease. Am J Respir Crit Care Med 151: 61-65. PMID: 7812573
30. Mahler DA, Weinberg DH, Wells CK, Feinstein AR (1984) The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 85: 751-758. PMID: 6723384
31. Mathis G (1993) Rare earth cryptates and homogeneous fluoroimmunoassays with human sera. Clin Chem 39: 1953-1959. PMID: 8375081
32. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, et al. (2012)-Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract.-Cochrane Database Syst Rev 2012 Sep 12; 9:CD007498 doi:: T-epublish. doi: 10.1002/14651858.CD007498.pub2 PMID: 22972110
33. Sethi S, Evans N, Grant BJ, Murphy TF (2002) New strains of bacteria and exacerbations of chronic obstructive pulmonary. N Engl J Med 347: 465-471. PMID: 12181400