A functional extracellular transcriptome in animals? Implications for biology, disease and medicine

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Tewari, Muneesh ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; SMALL NUCLEOLAR RNA; TRANSCRIPTOME; UNTRANSLATED RNA;

ARTICLE; BIOMEDICINE; CELL COMMUNICATION; CELLULAR DISTRIBUTION; CYTOLOGY; DISEASES; EXTRACELLULAR SPACE; MEDICAL TECHNOLOGY; MOLECULAR BIOLOGY; MOLECULAR GENETICS; NONHUMAN; PHYSIOLOGY; RNA TRANSPORT; ANIMAL; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; TRANSPORT VESICLE;

ANIMALIA;

ANIMALS; BIOLOGICAL TRANSPORT; EXTRACELLULAR SPACE; TRANSCRIPTOME; TRANSPORT VESICLES;

EID: 84924330606     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0613-5     Document Type: Article

References (12)

1. Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, et al. Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons. Nucleic Acids Res. 2014;42:9195-208. doi:10.1093/nar/gku594.
2. Vojtech L, Woo S, Hughes S, Levy C, Ballweber L, Sauteraud RP, et al. Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res. 2014;42:7290-304. doi:10.1093/nar/gku347.
3. Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014;25:501-15. doi:10.1016/j.ccr.2014.03.007.
4. Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, Dvorak P, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 2006;20:847-56. doi:10.1038/sj.leu.2404132.
5. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-9. doi:10.1038/ncb1596.
6. Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10:1470-6. doi:10.1038/ncb1800.
7. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A. 2011;108:5003-8. doi:10.1073/pnas.1019055108.
8. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011;13:423-33. doi:10.1038/ncb2210.
9. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010;39:133-44. doi:10.1016/j.molcel.2010.06.010.
10. Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 2011;71:3792-801. doi:10.1158/0008-5472.CAN-10-4455.
11. Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18:883-91. doi:10.1038/nm.2753.
12. Chevillet JR, Kang Q, Ruf IK, Briggs HA, Vojtech LN, Hughes SM, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci U S A. 2014;111:14888-93. doi:10.1073/pnas.1408301111.