Adolescent girls and young women: Key populations for HIV epidemic control

Journal of the International AIDS Society

Volumn 18, Issue 2, 2015, Pages 64-70

  Dellar, Rachael C ^a   Dlamini, Sarah ^a   Karim, Quarraisha Abdool ^a,b  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b Department of Epidemiology Mailman School of Public Health Columbia University ^*  (United States)

Author keywords

Adolescent girls; HIV prevention; Prevention interventions; Young women

Indexed keywords

ADOLESCENT; AFRICA; AGE; CHILD HEALTH CARE; CONDOM USE; EDUCATION PROGRAM; EPIDEMIC; EVIDENCE BASED PRACTICE; FEMALE; FOOD INSECURITY; GENDER BASED VIOLENCE; HEALTH CARE ACCESS; HEALTH DISPARITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; INFECTION CONTROL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCHOOL; SEX; SOCIAL BEHAVIOR; SPORTING EVENT; TRANSACTIONAL SEX; UROGENITAL TRACT INFECTION; VIRUS TRANSMISSION; VULNERABLE POPULATION; ADULT; EPIDEMICS; HIV INFECTIONS; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICA, SOUTHERN; EPIDEMICS; FEMALE; HIV INFECTIONS; HUMANS; YOUNG ADULT;

EID: 84924309944     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.18.2.19408     Document Type: Review

References (83)

1. UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2013 [cited 2014 Aug 14]. Available from: http://www.unaids.org/en/media/unaids/ contentassets/documents/epidemiology/2013/gr2013/UNAIDS-Global-Report- 2013-en.pdf
2. UNAIDS. 2008 Report on the global AIDS epidemic [cited 2014 Aug 14]. Available from: http://www.unaids.org/en/media/unaids/contentassets/dataimport/ pub/globalreport/2008/jc1510-2008globalreport-en.pdf
3. Anderson SJ, Cherutich P, Kilonzo N, Cremin I, Fecht D, Kimanga D, et al. Maximising the effect of combination HIV prevention through prioritisation of the people and places in greatest need: a modelling study. Lancet. 2014; 384:249-56.
4. Barnabas RV, Celum C. Bending the curve: maximising impact with focused HIV prevention. Lancet. 2014;384:216-7.
5. Shisana O, Rehle T, Simbayi LC, Zuma K, Jooste S, Zungu N, et al. South African national HIV prevalence, incidence and behaviour survey, 2012. Cape Town: HSRC Press; 2014.
6. Cowan F, Pettifor A. HIV in adolescents in sub-Saharan Africa. Curr Opin HIV AIDS. 2009;4:288-93.
7. Abdool Karim Q, Abdool Karim SS, Singh B, Short R, Ngxongo S. Seroprevalence of HIV infection in rural South Africa. AIDS. 1992;6:1535-9.
8. Abdool Karim Q, Kharsany AB, Leask K, Ntombela F, Humphries H, Frohlich JA, et al. Prevalence of HIV, HSV-2 and pregnancy among high school students in rural KwaZulu-Natal, South Africa: a bio-behavioural cross-sectional survey. Sex Transm Infect. 2014;90:620-6.
9. Abdool Karim Q, Abdool Karim SS. HIV/AIDS in South Africa. Cambridge: Cambridge University Press; 2010.
10. Abdool Karim Q, Dellar R. Inclusion of adolescent girls in HIV prevention research-an imperative for an AIDS-free generation. J Int AIDS Soc. 2014;17: 19075. doi: 10.7448/IAS.17.1.19075.
11. Fauci AS, Folkers GK, Dieffenbach CW. HIV-AIDS: much accomplished, much to do. Nat Immunol. 2013;14:1104-7.
12. Pettifor A, Bekker LG. Adolescent enrolment in HIV prevention trials. Lancet. 2012;380:646.
13. Gregson S, Nyamukapa CA, Garnett GP, Mason PR, Zhuwau T, Carael M, et al. Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe. Lancet. 2002;359:1896-903.
14. Pettifor A, Macphail C, Rees H, Cohen M. HIV and sexual behavior among young people: the South African paradox. Sex Transm Dis. 2008;35:843-4.
15. Pettifor AE, Measham DM, Rees HV, Padian NS. Sexual power and HIV risk, South Africa. Emerg Infect Dis. 2004;10:1996-2004.
16. Kelly RJ, Gray RH, Sewankambo NK, Serwadda D, Wabwire-Mangen F, Lutalo T, et al. Age differences in sexual partners and risk of HIV-1 infection in rural Uganda. J Acquir Immune Defic Syndr. 2003;32:446-51.
17. Pettifor AE, Rees HV, Kleinschmidt I, Steffenson AE, MacPhail C, Hlongwa-Madikizela L, et al. Young people's sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005;19:1525-34.
18. Kaiser R, Bunnell R, Hightower A, Kim AA, Cherutich P, Mwangi M, et al. Factors associated with HIV infection in married or cohabitating couples in Kenya: results from a nationally representative study. PLoS One. 2011;6: e17842.
19. Wamoyi J, Wight D, Plummer M, Mshana GH, Ross D. Transactional sex amongst young people in rural northern Tanzania: an ethnography of young women's motivations and negotiation. Reprod Health. 2010;7:2.
20. Stoebenau K, Nixon SA, Rubincam C, Willan S, Zembe YZ, Tsikoane T, et al. More than just talk: the framing of transactional sex and its implications for vulnerability to HIV in Lesotho, Madagascar and South Africa. Global Health. 2011;7:34.
21. Dunkle KL, Jewkes RK, Brown HC, Gray GE, McIntryre JA, Harlow SD. Transactional sex among women in Soweto, South Africa: prevalence, risk factors and association with HIV infection. Soc Sci Med. 2004;59:1581-92.
22. MacPherson EE, Sadalaki J, Njoloma M, Nyongopa V, Nkhwazi L, Mwapasa V, et al. Transactional sex and HIV: understanding the gendered structural drivers of HIV in fishing communities in Southern Malawi. J Int AIDS Soc. 2012; 15(Suppl 1):1-9. 17364, doi: 10.7448/IAS.15.3.17364.
23. Dixon-Mueller R. How young is ''too young''? Comparative perspectives on adolescent sexual, marital, and reproductive transitions. Stud Fam Plann. 2008; 39:247-62.
24. Hallman K. Gendered socioeconomic conditions and HIV risk behaviours among young people in South Africa. Afr J AIDS Res. 2005;4:37-50.
25. Hallman K. HIV vulnerability of non-enrolled and urban poor girls in KwaZulu-Natal, South Africa. New York, NY: Population Council; 2006.
26. Joint United Nations Programme on HIV/AIDS (UNAIDS), Interagency Task Team on HIV and Young People. Guidance brief: HIV interventions for most atrisk young people. New York: UNFPA; 2008.
27. Pettifor AE, van der Straten A, Dunbar MS, Shiboski SC, Padian NS. Early age of first sex: a risk factor for HIV infection among women in Zimbabwe. AIDS. 2004;18:1435-42.
28. Pettifor AE, Levandowski BA, MacPhail C, Padian NS, Cohen MS, Rees HV. Keep them in school: the importance of education as a protective factor against HIV infection among young South African women. Int J Epidemiol. 2008;37:1266-73.
29. Greif MJ. Housing, medical, and food deprivation in poor urban contexts: implications for multiple sexual partnerships and transactional sex in Nairobi's slums. Health Place. 2012;18:400-7.
30. Chatterji M, Murray N, London D, Anglewicz P. The factors influencing transactional sex among young men and women in 12 sub-Saharan African countries. Soc Biol. 2005;52:56-72.
31. Shefer T, Clowes L, Vergnani T. Narratives of transactional sex on a university campus. Cult Health Sex. 2012;14:435-47.
32. Weiser SD, Leiter K, Bangsberg DR, Butler LM, Percy-de Korte F, Hlanze Z, et al. Food insufficiency is associated with high-risk sexual behavior among women in Botswana and Swaziland. PLoS Med. 2007;4:1589-97; discussion 1598.
33. Weiser SD, Young SL, Cohen CR, Kushel MB, Tsai AC, Tien PC, et al. Conceptual framework for understanding the bidirectional links between food insecurity and HIV/AIDS. Am J Clin Nutr. 2011;94:1729S-39S.
34. Pettifor AE, Hudgens MG, Levandowski BA, Rees HV, Cohen MS. Highly efficient HIV transmission to young women in South Africa. AIDS. 2007;21: 861-5.
35. Yi TJ, Shannon B, Prodger J, McKinnon L, Kaul R. Genital immunology and HIV susceptibility in young women. Am J Reprod Immunol. 2013;69(Suppl 1): 74-9.
36. Glynn JR, Carael M, Auvert B, Kahindo M, Chege J, Musonda R, et al. Why do young women have a much higher prevalence of HIV than young men? A study in Kisumu, Kenya and Ndola, Zambia. AIDS. 2001;15(Suppl 4): S51-60.
37. Carpenter LM, Kamali A, Ruberantwari A, Malamba SS, Whitworth JA. Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV sero-status of the partners. AIDS. 1999;13:1083-9.
38. Hira SK, Nkowane BM, Kamanga J,Wadhawan D, Kavindele D, Macuacua R, et al. Epidemiology of human immunodeficiency virus in families in Lusaka, Zambia. J Acquir Immune Defic Syndr. 1990;3:83-6.
39. Padian NS, Shiboski SC, Glass SO, Vittinghoff E. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study. Am J Epidemiol. 1997;146:350-7.
40. Senkoro KP, Boerma JT, Klokke AH, Ng'weshemi JZ, Muro AS, Gabone R, et al. HIV incidence and HIV-associated mortality in a cohort of factory workers and their spouses in Tanzania, 1991 through 1996. J Acquir Immune Defic Syndr. 2000;23:194-202.
41. Kigozi G, Wawer M, Ssettuba A, Kagaayi J, Nalugoda F, Watya S, et al. Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters). AIDS. 2009;23:2209-13.
42. Jain R, Muralidhar S. Contraceptive methods: needs, options and utilization. J Obstet Gynaecol India. 2011;61:626-34.
43. Fish EN. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol. 2008;8:737-44.
44. Prodger JL, Gray R, Kigozi G, Nalugoda F, Galiwango R, Hirbod T, et al. Foreskin T-cell subsets differ substantially from blood with respect to HIV co-receptor expression, inflammatory profile, and memory status. Mucosal Immunol. 2012;5:121-8.
45. McKinnon LR, Nyanga B, Chege D, Izulla P, Kimani M, Huibner S, et al. Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility. J Immunol. 2011;187:6032-42.
46. Stanley M. Early age of sexual debut: a risky experience. J Fam Plann Reprod Health Care. 2009;35:118-20.
47. Hwang LY, Scott ME, Ma Y, Moscicki AB. Higher levels of cervicovaginal inflammatory and regulatory cytokines and chemokines in healthy young women with immature cervical epithelium. J Reprod Immunol. 2011;88:66-71.
48. Ghanem KG, Shah N, Klein RS, Mayer KH, Sobel JD, Warren DL, et al. Influence of sex hormones, HIV status, and concomitant sexually transmitted infection on cervicovaginal inflammation. J Infect Dis. 2005;191:358-66.
49. Levinson P, Kaul R, Kimani J, Ngugi E, Moses S, MacDonald KS, et al. Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS. 2009;23: 309-17.
50. Rottingen JA, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much really is known? Sex Transm Dis. 2001;28:579-97.
51. Cohen MS. HIV and sexually transmitted diseases: lethal synergy. Top HIV Med. 2004;12:104-7.
52. Nagot N, Ouedraogo A, Foulongne V, Konate I, Weiss HA, Vergne L, et al. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med. 2007;356:790-9.
53. Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis. 2002; 185:45-52.
54. Morrison CS, Turner AN, Jones LB. Highly effective contraception and acquisition of HIV and other sexually transmitted infections. Best Pract Res Clin Obstet Gynaecol. 2009;23:263-84.
55. Low N, Chersich MF, Schmidlin K, Egger M, Francis SC, van de Wijgert JH, et al. Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis. PLoS Med. 2011;8:e1000416.
56. McClelland RS, Lavreys L, Hassan WM, Mandaliya K, Ndinya-Achola JO, Baeten JM. Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective study. AIDS. 2006;20:269-73.
57. Mavedzenge SN, Luecke E, Ross DA. Effectiveness of HIV prevention, treatment and care interventions among adolescents: a systematic review of systematic reviews. UNICEF technical brief. New York: UNICEF; 2013.
58. Yankah E, Aggleton P. Effects and effectiveness of life skills education for HIV prevention in young people. AIDS Educ Prev. 2008;20:465 -85.
59. Michielsen K, Chersich MF, Luchters S, De Koker P, Van Rossem R, Temmerman M. Effectiveness of HIV prevention for youth in sub-Saharan Africa: systematic review and meta-analysis of randomized and nonrandomized trials. AIDS. 2010;24:1193- 202.
60. Harrison A, Newell ML, Imrie J, Hoddinott G. HIV prevention for South African youth: which interventions work? A systematic review of current evidence. BMC Public Health. 2010;10:102.
61. Agbemenu K, Schlenk EA. An integrative review of comprehensive sex education for adolescent girls in Kenya. J Nurs Scholarsh. 2011;43:54-63.
62. Napierala Mavedzenge SM, Doyle AM, Ross DA. HIV prevention in young people in sub-Saharan Africa: a systematic review. J Adolesc Health. 2011;49: 568-86.
63. Chin HB, Sipe TA, Elder R, Mercer SL, Chattopadhyay SK, Jacob V, et al. The effectiveness of group-based comprehensive risk-reduction and abstinence education interventions to prevent or reduce the risk of adolescent pregnancy, human immunodeficiency virus, and sexually transmitted infections: two systematic reviews for the Guide to Community Preventive Services. Am J Prev Med. 2012;42:272 -94.
64. Paul-Ebhohimhen VA, Poobalan A, van Teijlingen ER. A systematic review of school-based sexual health interventions to prevent STI/HIV in sub-Saharan Africa. BMC Public Health. 2008;8:4.
65. Robin L, Dittus P, Whitaker D, Crosby R, Ethier K, Mezoff J, et al. Behavioral interventions to reduce incidence of HIV, STD, and pregnancy among adolescents: a decade in review. J Adolesc Health. 2004;34:3-26.
66. Sales JM, Milhausen RR, Diclemente RJ. A decade in review: building on the experiences of past adolescent STI/HIV interventions to optimise future prevention efforts. Sex Transm Infect. 2006;82:431- 6.
67. Gallant M, Maticka-Tyndale E. School-based HIV prevention programmes for African youth. Soc Sci Med. 2004;58:1337- 51.
68. Morrison-Beedy D, Nelson LE. HIV prevention interventions in adolescent girls: what is the state of the science? Worldviews Evid Based Nurs. 2004;1: 165-75.
69. Kirby DB, Laris BA, Rolleri LA. Sex and HIV education programs: their impact on sexual behaviors of young people throughout the world. J Adolesc Health. 2007;40:206- 17.
70. Speizer IS, Magnani RJ, Colvin CE. The effectiveness of adolescent reproductive health interventions in developing countries: a review of the evidence. J Adolesc Health. 2003;33:324-48.
71. DiCenso A, Guyatt G, Willan A, Griffith L. Interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trials. BMJ. 2002;324:1426.
72. Doyle AM, Ross DA, Maganja K, Baisley K, Masesa C, Andreasen A, et al. Long-term biological and behavioural impact of an adolescent sexual health intervention in Tanzania: follow-up survey of the community-based MEMA kwa Vijana Trial. PLoS Med. 2010;7:e1000287.
73. Ross DA, Changalucha J, Obasi AI, Todd J, Plummer ML, Cleophas-Mazige B, et al. Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trial. AIDS. 2007;21:1943-55.
74. Cowan FM, Pascoe SJ, Langhaug LF, Mavhu W, Chidiya S, Jaffar S, et al. The Regai Dzive Shiri project: results of a randomized trial of an HIV prevention intervention for youth. AIDS. 2010;24:2541-52.
75. Dick B, Ferguson J, Chandra-Mouli V, Brabin L, Chatterjee S, Ross DA. Review of the evidence for interventions to increase young people's use of health services in developing countries. World Health Organ Tech Rep Ser. 2006;938:151-204; discussion 317-41.
76. Denno DM, Chandra-Mouli V, Osman M. Reaching youth with out-of-facility HIV and reproductive health services: a systematic review. J Adolesc Health. 2012;51:106-21.
77. Zuurmond MA, Geary RS, Ross DA. The effectiveness of youth centers in increasing use of sexual and reproductive health services: a systematic review. Stud Fam Plann. 2012;43:239 -54.
78. Maticka-Tyndale E, Brouillard-Coylea C. The effectiveness of community interventions targeting HIV and AIDS prevention at young people in developing countries. World Health Organ Tech Rep Ser. 2006;938:243-85; discussion 317- 41.
79. Jewkes R, Nduna M, Levin J, Jama N, Dunkle K, Puren A, et al. Impact of stepping stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial. BMJ. 2008;337:a506.
80. Pettifor A, MacPhail C, Nguyen N, Rosenberg M. Can money prevent the spread of HIV? A review of cash payments for HIV prevention. AIDS Behav. 2012;16:1729-38.
81. th International AIDS Conference on HIV Pathogenesis, Treatment and Prevention; June 30-July 3 2013. Kuala Lumpur: STI (BMJ); 2013.
82. Baird SJ, Garfein RS, McIntosh CT, Ozler B. Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomised trial. Lancet. 2012;379:1320-9.
83. Pettifor A, Bekker LG, Hosek S, DiClemente R, Rosenberg M, Bull SS, et al. Preventing HIV among young people: research priorities for the future. J Acquir Immune Defic Syndr. 2013;63(Suppl 2):S155-60.