Percutaneous intramyocardial delivery of mesenchymal stem cells induces superior improvement in regional left ventricular function compared with bone marrow mononuclear cells in porcine myocardial infarcted heart

Theranostics

Volumn 5, Issue 2, 2015, Pages 196-205

  Tao, Bo ^a   Cui, Mingliang ^a   Wang, Chen ^a   Ma, Sai ^a   Wu, Feng ^a   Yi, Fu ^a   Qin, Xing ^a   Liu, Junting ^c   Wang, Haichang ^a   Wang, Zhe ^a   Ma, Xiaowei ^a   Tian, Jie ^c   Chen, Yundai ^b   Wang, Jing ^a   Cao, Feng ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c XIDIAN UNIVERSITY   (China)

Author keywords

Angiogenesis; Imaging; Myocardial infarction; Remodeling; Stem cells

Indexed keywords

PHOSPHATE BUFFERED SALINE;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BLOOD VESSEL PARAMETERS; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MARROW DERIVED MONONUCLEAR CELL; CARDIOVASCULAR PARAMETERS; CELL PROLIFERATION; CLINICAL EFFECTIVENESS; COLLAGEN SYNTHESIS; CORONARY ARTERY OBSTRUCTION; ECHOCARDIOGRAPHY; ENGRAFTMENT; FEASIBILITY STUDY; GATED SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE FIBROSIS; HEART MUSCLE PERFUSION; HISTOPATHOLOGY; INTERMETHOD COMPARISON; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEFT VENTRICULAR SYSTOLIC WALL THICKENING; MESENCHYMAL STEM CELL TRANSPLANTATION; MINIPIG; NONHUMAN; PERCUTANEOUS INTRAMYOCARDIAL BONE MARROW MESENCHYMAL STEM CELL THERAPY; TREATMENT OUTCOME; VASCULAR DENSITY; ANIMAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DISEASE MODEL; HEART; MYOCARDIAL INFARCTION; PATHOLOGY; PHYSIOLOGY; PIG; PROCEDURES;

ANIMALS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; HEART; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; SWINE; SWINE, MINIATURE; TOMOGRAPHY, EMISSION-COMPUTED; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 84924292743     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.7976     Document Type: Article

References (31)

1. Rosenzweig A. Cardiac cell therapy--mixed results from mixed cells. N Engl J Med. 2006; 355: 1274-7. doi:10.1056/NEJMe068172.
2. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004; 364: 141-8. doi:10.1016/S0140-6736(04)16626-9.
3. Assmus B, Honold J, Schachinger V, Britten MB, Fischer-Rasokat U, Lehmann R, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med. 2006; 355: 1222-32. doi:10.1056/NEJMoa051779.
4. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet. 2006; 367: 113-21. doi:10.1016/S0140-6736(05)67861-0.
5. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med. 2006; 355: 1199-209. doi:10.1056/NEJMoa055706.
6. Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Holschermann H, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006; 355: 1210-21. doi:10.1056/NEJMoa060186.
7. Cao F, Sun D, Li C, Narsinh K, Zhao L, Li X, et al. Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up. Eur Heart J. 2009; 30: 1986-94. doi:10.1093/eurheartj/ehp220.
8. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143-7.
9. Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A. 2005; 102: 11474-9. doi:10.1073/pnas.0504388102.
10. Halkos ME, Zhao ZQ, Kerendi F, Wang NP, Jiang R, Schmarkey LS, et al. Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction. Basic Res Cardiol. 2008; 103: 525-36. doi:10.1007/s00395-008-0741-0.
11. Quevedo HC, Hatzistergos KE, Oskouei BN, Feigenbaum GS, Rodriguez JE, Valdes D, et al. Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A. 2009; 106: 14022-7. doi:10.1073/pnas.0903201106.
12. Parekkadan B, Milwid JM. Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng. 2010; 12: 87-117. doi:10.1146/annurev-bioeng-070909-105309.
13. Niccoli-Asabella A, Ferlan G, Crovace A, Notaristefano A, Rubini D, Altini C, et al. Swine experimental model to evaluate stem cells implant post myocardial infarction by perfusion gated-SPET. Hell J Nucl Med. 2012; 15: 16-22.
14. Freyman T, Polin G, Osman H, Crary J, Lu M, Cheng L, et al. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J. 2006; 27: 1114-22. doi:ehi818 [pii]10.1093/eurheartj/ehi818.
15. Williams AR, Trachtenberg B, Velazquez DL, McNiece I, Altman P, Rouy D, et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. Circ Res. 2011; 108: 792-6. doi:10.1161/CIRCRESAHA.111.242610.
16. Hatzistergos KE, Quevedo H, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010; 107: 913-22. doi:10.1161/CIRCRESAHA.110.222703.
17. Kim BO, Tian H, Prasongsukarn K, Wu J, Angoulvant D, Wnendt S, et al. Cell transplantation improves ventricular function after a myocardial infarction: a preclinical study of human unrestricted somatic stem cells in a porcine model. Circulation. 2005; 112: I96-104. doi:10.1161/01.CIRCULATIONAHA.105.524678.
18. Gavira JJ, Nasarre E, Abizanda G, Perez-Ilzarbe M, de Martino-Rodriguez A, Garcia de Jalon JA, et al. Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction. Eur Heart J. 2010; 31: 1013-21. doi:ehp342 [pii]10.1093/eurheartj/ehp342.
19. Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD. Intra- coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet. 2004; 363: 783-4. doi:10.1016/S0140-6736(04)15695-X.
20. Hofmann M, Wollert KC, Meyer GP, Menke A, Arseniev L, Hertenstein B, et al. Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation. 2005; 111: 2198-202. doi: 10.1161/01.CIR.0000163546.27639.AA.
21. Schoenhard JA, Hatzopoulos AK. Time is like a clock in my heart: implications for stem cell delivery after myocardial infarction. Cardiology. 2010; 117: 158-60. doi:10.1159/000321396.
22. Strauer BE, Steinhoff G. 10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice. J Am Coll Cardiol. 2011; 58: 1095-104. doi:S0735-1097(11)02285-6 [pii]10.1016/j.jacc.2011.06.016.
23. Mazo M, Gavira JJ, Abizanda G, Moreno C, Ecay M, Soriano M, et al. Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat. Cell Transplant. 2010; 19: 313-28. doi:10.3727/096368909X480323.
24. van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, et al. Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation. 2008; 118: S121-9. doi:10.1161/CIRCULATIONAHA.107.759480.
25. Hashemi SM, Ghods S, Kolodgie FD, Parcham-Azad K, Keane M, Hamamdzic D, et al. A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarction. Eur Heart J. 2008; 29: 251-9. doi:10.1093/eurheartj/ehm559.
26. Moelker AD, Baks T, van den Bos EJ, van Geuns RJ, de Feyter PJ, Duncker DJ, et al. Reduction in infarct size, but no functional improvement after bone marrow cell administration in a porcine model of reperfused myocardial infarction. Eur Heart J. 2006; 27: 3057-64. doi:10.1093/eurheartj/ehl401.
27. Jameel MN, Li Q, Mansoor A, Qiang X, Sarver A, Wang X, et al. Long-term functional improvement and gene expression changes after bone marrow- derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol. 2010; 298: H1348-56. doi:10.1152/ajpheart.01100.2009.
28. Sheikh AY, Huber BC, Narsinh KH, Spin JM, van der Bogt K, de Almeida PE, et al. In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol. 2012; 32: 92-102. doi:10.1161/ATVBAHA.111.238618.
29. Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol. 2012; 59: 942-53. doi:10.1016/j.jacc.2011.11.029.
30. Ohnishi S, Sumiyoshi H, Kitamura S, Nagaya N. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett. 2007; 581: 3961-6. doi:10.1016/j.febslet.2007.07.028.
31. Yang YJ, Qian HY, Huang J, Geng YJ, Gao RL, Dou KF, et al. Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts. Eur Heart J. 2008; 29: 1578-90. doi:10.1093/eurheartj/ehn167.