Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Tsumuraya, Tomomi ^a,b   Ohtaki, Hirokazu ^a   Song, Dandan ^a   Sato, Atsushi ^a,b   Watanabe, Jun ^a   Hiraizumi, Yutaka ^a   Nakamachi, Tomoya ^a,c   Xu, Zhifang ^a   Dohi, Kenji ^a,d   Hashimoto, Hitoshi ^e   Atsumi, Takashi ^b   Shioda, Seiji ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

Human mesenchymal stem stromal cells (hMSCs); Macrophage; Microglia; Pituitary adenylate cyclase activating polypeptide (PACAP); Spinal cord injury

Indexed keywords

ARGINASE; GAMMA INTERFERON; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ADCYAP1 PROTEIN, MOUSE; CYTOKINE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; LIPOPOLYSACCHARIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; LOCOMOTION; MACROPHAGE ACTIVATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROGLIA; MOLECULAR INTERACTION; MOUSE; MYELITIS; NERVE CELL; NONHUMAN; POSTOPERATIVE PERIOD; SPINAL CORD TRANSSECTION; UPREGULATION; WILD TYPE; ANIMAL; BIOLOGICAL THERAPY; C57BL MOUSE; CELL MOTION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; SPINAL CORD INJURIES; TIME FACTOR; TRANSFORMED CELL LINE; TRANSGENIC MOUSE;

ANIMALS; CELL LINE, TRANSFORMED; CELL MOVEMENT; CELL- AND TISSUE-BASED THERAPY; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; LOCOMOTION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I; SPINAL CORD INJURIES; TIME FACTORS;

EID: 84924242180     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0252-5     Document Type: Article

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