Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Conroy, Andrea L ^a,b   Hawkes, Michael ^c   Hayford, Kyla ^a,b   Namasopo, Sophie ^d   Opoka, Robert O ^e   John, Chandy C ^f   Liles, W Conrad ^g   Kain, Kevin C ^a,b,h  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d Jinja Regional Referral Hospital   (Uganda)

^e MULAGO HOSPITAL   (Uganda)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

^h MaRS Centre   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CALIBRATION; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FEVER; HUMAN; INFANT; LAMBARENE ORGAN DYSFUNCTION SCORE; MAJOR CLINICAL STUDY; MALARIA; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PEDIATRIC EARLY DEATH INDEX FOR AFRICA; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SCORING SYSTEM; SIGNS OF INFLAMMATION IN CHILDREN THAT KILL SCORE; SURVIVOR; UGANDAN; VALIDATION STUDY; YOUDEN INDEX; CLASSIFICATION; HOSPITAL MORTALITY; INFLAMMATION; INTENSIVE CARE UNIT; MORTALITY; ORGAN DYSFUNCTION SCORE; PRESCHOOL CHILD; REPRODUCIBILITY; SEVERITY OF ILLNESS INDEX; UGANDA;

CHILD, PRESCHOOL; FEMALE; FEVER; HOSPITAL MORTALITY; HUMANS; INFANT; INFLAMMATION; INTENSIVE CARE UNITS; MALARIA; MALE; ORGAN DYSFUNCTION SCORES; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; ROC CURVE; SEVERITY OF ILLNESS INDEX; UGANDA;

EID: 84924230150     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0773-4     Document Type: Article

References (21)

1. Rajaratnam JK, Marcus JR, Flaxman AD, Wang H, Levin-Rector A, Dwyer L, et al. Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970-2010: a systematic analysis of progress towards Millennium Development Goal 4. Lancet. 2010;375:1988-2008.
2. Wang H, Liddell CA, Coates MM, Mooney MD, Levitz CE, Schumacher AE, et al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:957-79.
3. United Nations Children's Fund. Levels & Trends in Child Mortality. Report 2013. Estimates Developed by the UN Inter-agency Group for Child Mortality Estimation. 3 UN Plaza, New York, New York, 10017 USA: United Nations Children's Fund; 2013.
4. World Health Organization. Emergency triage assessment and treatment course. 20, Avenue Appia, 1211 Geneva 27, Switzerland: World Health Organization; 2005.
5. Pollack MM, Ruttimann UE, Getson PR. Pediatric risk of mortality (PRISM) score. Crit Care Med. 1988;16:1110-6.
6. Shann F, Pearson G, Slater A, Wilkinson K. Paediatric index of mortality (PIM): a mortality prediction model for children in intensive care. Intensive Care Med. 1997;23:201-7.
7. Helbok R, Issifou S, Matsiegui PB, Lackner P, Missinou MA, Kombila D, et al. Simplified multi-organ dysfunction score predicts disability in African children with Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006;75:443-7.
8. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet. 2003;362:192-7.
9. Duncan H, Hutchison J, Parshuram CS. The Pediatric Early Warning System score: a severity of illness score to predict urgent medical need in hospitalized children. J Crit Care. 2006;21:271-8.
10. Parshuram CS, Hutchison J, Middaugh K. Development and initial validation of the Bedside Paediatric Early Warning System score. Crit Care. 2009;13:R135.
11. Egdell P, Finlay L, Pedley DK. The PAWS score: validation of an early warning scoring system for the initial assessment of children in the emergency department. Emerg Med J. 2008;25:745-9.
12. Kumar N, Thomas N, Singhal D, Puliyel JM, Sreenivas V. Triage score for severity of illness. Indian Pediatr. 2003;40:204-10.
13. Gupta MA, Chakrabarty A, Halstead R, Sahni M, Rangasami J, Puliyel A, et al. Validation of "Signs of Inflammation in Children that Kill" (SICK) score for immediate non-invasive assessment of severity of illness. Ital J Pediatr. 2010;36:35.
14. Helbok R, Kendjo E, Issifou S, Lackner P, Newton Charles R, Kombila M, et al. The Lambaréné Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children. J Infect Dis. 2009;200:1834-41.
15. Berkley JA, Ross A, Mwangi I, Osier FH, Mohammed M, Shebbe M, et al. Prognostic indicators of early and late death in children admitted to district hospital in Kenya: cohort study. BMJ. 2003;326:361.
16. Okello PE, Van Bortel W, Byaruhanga AM, Correwyn A, Roelants P, Talisuna A, et al. Variation in malaria transmission intensity in seven sites throughout Uganda. Am J Trop Med Hyg. 2006;75:219-25.
17. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, et al. Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children. Malar J. 2014;13:43.
18. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837-45.
19. Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, et al. Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006;100:615-22.
20. Kendjo E, Agbenyega T, Bojang K, Newton CR, Bouyou-Akotet M, Pedross F, et al. Mortality patterns and site heterogeneity of severe malaria in African children. PLoS One. 2013;8:e58686.
21. Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, Cousens S, et al. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities. PLoS Med. 2011;8:e1001080.