Ketogenic diet therapy is effective in encephalitis with refractory seizures

Neurological Research

Volumn 36, Issue 10, 2014, Pages 906-910

  Matsuzono, Kosuke ^a   Kurata, Tomoko ^a   Deguchi, Shoko ^a   Yamashita, Toru ^a   Deguchi, Kentaro ^a   Abe, Koji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

AERRPS; Encephalitis; Ketogenic diet therapy; Refractory seizures; SPECT with 123I iomazenil

Indexed keywords

ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CARBAMAZEPINE; CREATINE KINASE; ETIRACETAM; INTERLEUKIN 6; IOMAZENIL; LOXOPROFEN; METHYLPREDNISOLONE; MYOGLOBIN; PHENOBARBITAL; PHENYTOIN; THIOPENTAL; THYROTROPIN; TOPIRAMATE; VALPROIC ACID;

ADULT; ARTICLE; CASE REPORT; CERVICAL LYMPHADENOPATHY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; FEVER; HEADACHE; HUMAN; HYPOREFLEXIA; KETOGENIC DIET; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; RASH; REAL TIME POLYMERASE CHAIN REACTION; REFRACTORY SEIZURE; SEIZURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; YOUNG ADULT; BRAIN; DIET THERAPY; DIFFUSION WEIGHTED IMAGING; DRUG RESISTANCE; PATHOLOGY; PATHOPHYSIOLOGY; SEIZURES;

BRAIN; DIFFUSION MAGNETIC RESONANCE IMAGING; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; HUMANS; KETOGENIC DIET; MALE; SEIZURES; YOUNG ADULT;

EID: 84924179514     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132814Y.0000000371     Document Type: Article

References (19)

1. van Lierde I, van Paesschen W, Dupont P, Maes A, Sciot R. De novo cryptogenic refractory multifocal febrile status epilepticus in the young adult: a review of six cases. Acta Neurol Belg. 2003;103(2):88-94.
2. Baxter P, Clarke A, Cross H, Harding B, Hicks E, Livingston J, et al. Idiopathic catastrophic epileptic encephalopathy presenting with acute onset intractable status. Seizure. 2003;12(6):379-87.
3. Wilder-Smith EP, Lim EC, Teoh HL, Sharma VK, Tan JJ, Chan BP, et al. The NORSE (new-onset refractory status epilepticus) syndrome: defining a disease entity. Ann Acad Med Sing. 2005;34(7):417-20.
4. Kramer U, Shorer Z, Ben-Zeev B, Lerman-Sagie T, Goldberg-Stern H, Lahat E. Severe refractory status epilepticus owing to presumed encephalitis. J Child Neurol. 2005;20(3):184-7.
5. Mikaeloff Y, Jambaque I, Hertz-Pannier L, Zamfirescu A, Adamsbaum C, Plouin P, et al. Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis. Epilepsy Res. 2006;69(1):67-79.
6. Awaya Y, Fukuyama Y, Hayashi K, Osawa M. [Acute nonherpetic encephalitis with severe refractory status epilepticus — its overwhelming ictogenicity, epileptogenicity, long-term prognosis and review of the literature]. No To Hattatsu. 2007;39(2):138-44. Japanese.
7. Sakuma H, Awaya Y, Shiomi M, Yamanouchi H, Takahashi Y, Saito Y et al. Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand. 2010;121(4):251-6.
8. van Baalen A, Hausler M, Boor R, Rohr A, Sperner J, Kurlemann G, et al. Febrile infection-related epilepsy syndrome (FIRES): a nonencephalitic encephalopathy in childhood. Epilepsia. 2010;51(7):1323-8.
9. Nabbout R, Mazzuca M, Hubert P, Peudennier S, Allaire C, Flurin V, et al. Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia. 2010;51(10):2033-7.
10. Saito Y, Maegaki Y, Okamoto R, Ogura K, Togawa M, Nanba Y, et al. Acute encephalitis with refractory, repetitive partial seizures: case reports of this unusual post-encephalitic epilepsy. Brain Dev. 2007;29(3):147-56.
11. Shyu CS, Lee HF, Chi CS, Chen CH. Acute encephalitis with refractory, repetitive partial seizures. Brain Dev. 2008;30(5):356-61.
12. Sakuma H. Acute encephalitis with refractory, repetitive partial seizures. Brain Dev. 2009;31(7):510-4.
13. Ismail FY, Kossoff EH. AERRPS, DESC, NORSE, FIRES: multi-labeling or distinct epileptic entities? Epilepsia. 2011;52(11):e185-9.
14. Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, et al. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia. 2011;52(11):1956-65.
15. Yudkoff M, Daikhin Y, Horyn O, Nissim I, Nissim I. Ketosis and brain handling of glutamate, glutamine, and GABA. Epilepsia. 2008;49(Suppl 8):73-5.
16. Masino SA, Rho JM. Mechanisms of ketogenic diet action. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper’s basic mechanisms of the epilepsies. 4th ed. Bethesda, MD: National Center for Biotechnology Information; 2012:1-28.
17. Politi K, Shemer-Meiri L, Shuper A, Aharoni S. The ketogenic diet 2011: how it works. Epilepsy Res Treat. 2011;2011:963637.
18. McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. 2011;52(3):e7-11.
19. Nylen K, Likhodii S, Burnham WM. The ketogenic diet: proposed mechanisms of action. Neurotherapeutics. 2009;6(2):402-5.