Mass spectrometric immunoassay raises doubt for the existence of parathyroid hormone fragment 7-84

Clinical Chemistry

Volumn 61, Issue 3, 2015, Pages 558-560

  Singh, Ravinder J ^a   Hines, Jolaine M ^a   Lopez, Mary F ^b   Krastins, Bryan ^b   Hoofnagle, Andrew N ^c  

^a MAYO CLINIC   (United States)

^b Thermo Fisher Scientific   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MONOCLONAL ANTIBODY; PARATHYROID HORMONE; PARATHYROID HORMONE[7-84]; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG; PARATHYROID HORMONE (7-84); PEPTIDE FRAGMENT;

ANTIBODY AFFINITY; HUMAN; IMMUNOASSAY; IMMUNOASSAY ANALYZER; LETTER; MASS SPECTROMETRY; PARATHYROID HORMONE BLOOD LEVEL; AMINO ACID SEQUENCE; BLOOD; CHEMISTRY; ISOLATION AND PURIFICATION; PROCEDURES; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; HUMANS; IMMUNOASSAY; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; TANDEM MASS SPECTROMETRY;

EID: 84923930351     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2014.235440     Document Type: Letter

References (5)

1. Cantor T, Yang Z, Caraiani N, Ilamathi E. Lack of comparability of intact parathyroid hormone measurements among commercial assays for end-stage renal disease patients: implication for treatment decisions. Clin Chem 2006;52:1771-6.
2. La'ulu SL, Roberts WL. Performance characteristics of six intact parathyroid hormone assays. Am J Clin Pathol 2010;134:930-8.
3. Tan K, Ong L, Sethi SK, Saw S. Comparison of the Elecsys PTH(1-84) assay with four contemporary second generation intact PTH assays and association with other biomarkers in chronic kidney disease patients. Clin Biochem 2013;46:781-6.
4. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, D'Amour P. A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem 1998;44:805-9.
5. Lopez MF, Rezai T, Sarracino DA, Prakash A, Krastins B, Athanas M, et al. Selected reaction monitoring-mass spectrometric immunoassay responsive to parathyroid hormone and related variants. Clin Chem 2010;56:281-90.