Progressive multifocal leukoencephalopathy associated with belimumab in a patient with systemic lupus erythematosus

Journal of Rheumatology

Volumn 42, Issue 3, 2015, Pages 551-552

  Leblanc Trudeau, Charlotte ^a   Masetto, Ariel ^a   Bocti, Christian ^b  

^a Department of Rheumatology ^*  (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BELIMUMAB; HYDROXYCHLOROQUINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; MONOCLONAL ANTIBODY;

ADL DISABILITY; ADULT; ANEMIA; APATHY; APHASIA; ARTHRITIS; ARTICLE; BRAIN EDEMA; CASE REPORT; CEREBROSPINAL FLUID CULTURE; COGNITIVE DEFECT; DETERIORATION; DISEASE DURATION; DRUG RESPONSE; DRUG WITHDRAWAL; EXECUTIVE FUNCTION; FATIGUE; FEMALE; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INDEPENDENT LIVING; JC VIRUS; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; RASH; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; WHITE MATTER LESION; BRAIN; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; LUPUS ERYTHEMATOSUS, SYSTEMIC; PATHOLOGY;

ANTIBODIES, MONOCLONAL, HUMANIZED; BRAIN; FEMALE; HUMANS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED;

EID: 84923868596     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.140577     Document Type: Article

References (5)

1. Molloy ES, Calabrese LH. Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies. Arthritis Rheum 2012;64:3043-51.
2. Hahn BH. Belimumab for systemic lupus erythematosus. N Engl J Med 2013;368:1528-35.
3. Fredericks C, Kvam K, Bear J, Crabtree G, Josephson S. A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab. Lupus 2014;23:711-3.
4. Wallace DJ, Navarra S, Petri MA, Gallacher A, Thomas M, Furie R, et al. Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus. Lupus 2013;22:144-54.
5. Nived O, Bengtsson AA, Jönsen A, Sturfelt G. Progressive multifocal leukoencephalopathy - the importance of early diagnosis illustrated in four cases. Lupus 2008;17:1036-41.