메뉴 건너뛰기




Volumn 49, Issue 3, 2015, Pages 343-350

Ledipasvir-Sofosbuvir: Interferon-/Ribavirin-Free Regimen for Chronic Hepatitis C Virus Infection

Author keywords

hepatitis C virus; ledipasvir; sofosbuvir

Indexed keywords

ABACAVIR; ANTACID AGENT; ANTICONVULSIVE AGENT; ANTIHISTAMINIC AGENT; ANTIMYCOBACTERIAL AGENT; ATAZANAVIR PLUS RITONAVIR; CYCLOSPORIN; DARUNAVIR PLUS RITONAVIR; DIGOXIN; DRUG METABOLITE; EFAVIRENZ; EMTRICITABINE; GS 331007; HYPERICUM PERFORATUM EXTRACT; LAMIVUDINE; LEDIPASVIR PLUS SOFOSBUVIR; ORAL CONTRACEPTIVE AGENT; PEGINTERFERON; PROTON PUMP INHIBITOR; RALTEGRAVIR; RIBAVIRIN; RILPIVIRINE; RITONAVIR PLUS TIPRANAVIR; ROSUVASTATIN; SIMEPREVIR; TACROLIMUS; TENOFOVIR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; FLUORENE DERIVATIVE; INTERFERON; LEDIPASVIR; SOFOSBUVIR; URIDINE PHOSPHATE;

EID: 84923841742     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014563952     Document Type: Review
Times cited : (25)

References (47)
  • 1
    • 84867288022 scopus 로고    scopus 로고
    • Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965
    • Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965.MMWR Recomm Rep. 2012;61 (RR-4): 1-32
    • (2012) MMWR Recomm Rep , vol.61 , Issue.RR-4 , pp. 1-32
  • 2
    • 84904507580 scopus 로고    scopus 로고
    • Sofosbuvir: a nucleotide NS5B inhibitor for the treatment of chronic hepatitis C infection
    • Rose L,Bias TE,Mathias CB,Trooskin SB,Fong JJ.Sofosbuvir: a nucleotide NS5B inhibitor for the treatment of chronic hepatitis C infection.Ann Pharmacother. 2014;48:1019-1029
    • (2014) Ann Pharmacother , vol.48 , pp. 1019-1029
    • Rose, L.1    Bias, T.E.2    Mathias, C.B.3    Trooskin, S.B.4    Fong, J.J.5
  • 3
    • 84923835691 scopus 로고    scopus 로고
    • Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C. Accessed November 29, 2014
    • Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C. http://www.hcvguidelines.org/. Accessed November 29, 2014.
  • 4
    • 84876556033 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication
    • Lohmann V.Hepatitis C virus RNA replication.Curr Top Microbiol Immunol. 2013;369:167-198
    • (2013) Curr Top Microbiol Immunol , vol.369 , pp. 167-198
    • Lohmann, V.1
  • 5
    • 84896308812 scopus 로고    scopus 로고
    • Discovery and development of hepatitis C virus NS5A replication complex inhibitors
    • ,,, et al.. ;:-
    • Belema M,Lopez OD,Bender JA, et al.Discovery and development of hepatitis C virus NS5A replication complex inhibitors.J Med Chem. 2014;57:1643-1672
    • (2014) J Med Chem , vol.57 , pp. 1643-1672
    • Belema, M.1    Lopez, O.D.2    Bender, J.A.3
  • 6
    • 84896295869 scopus 로고    scopus 로고
    • Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection
    • ,,, et al.. ;:-
    • Link JO,Taylor JG,Xu L, et al.Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.J Med Chem. 2014;57:2033-2046
    • (2014) J Med Chem , vol.57 , pp. 2033-2046
    • Link, J.O.1    Taylor, J.G.2    Xu, L.3
  • 7
    • 84887460791 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885
    • ,,, et al.. ;:-
    • Wong KA,Worth A,Martin R, et al.Characterization of hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885.Antimicrob Agents Chemother. 2013;57:6333-6340
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 6333-6340
    • Wong, K.A.1    Worth, A.2    Martin, R.3
  • 8
    • 84862684876 scopus 로고    scopus 로고
    • A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C
    • ,,, et al.. ;:-
    • Lawitz EJ,Gruener D,Hill JM, et al.A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C.J Hepatol. 2012;57:24-31
    • (2012) J Hepatol , vol.57 , pp. 24-31
    • Lawitz, E.J.1    Gruener, D.2    Hill, J.M.3
  • 10
    • 84923835689 scopus 로고    scopus 로고
    • Foster City, CA: ; :, Gilead Sciences, Inc
    • Foster City, CA: Gilead Sciences, Inc; 2014:
    • (2014)
  • 12
    • 84923838701 scopus 로고    scopus 로고
    • The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor, in HCV-uninfected subjects with severe renal impairment [abstract]
    • ,,, et al.. ;:-
    • Mogalian E,Mathias A,Yang C, et al.The pharmacokinetics of ledipasvir, an HCV specific NS5A inhibitor, in HCV-uninfected subjects with severe renal impairment [abstract].Hepatology (Baltimore, Md). 2014;60:1145A-1146A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1145-1146
    • Mogalian, E.1    Mathias, A.2    Yang, C.3
  • 13
    • 84923835687 scopus 로고    scopus 로고
    • Department of Health and Human Services. Management of hepatitis C: 2002 National Institutes of Health Consensus Conference Statement. Accessed November 29, 2014
    • Department of Health and Human Services. Management of hepatitis C: 2002 National Institutes of Health Consensus Conference Statement. http://consensus.nih.gov/2002/2002-hepatitisc2002116html.htm. Accessed November 29, 2014.
  • 14
    • 84877782905 scopus 로고    scopus 로고
    • Earlier sustained virologic response end points for regulatory approval and dose selection of hepatitis C therapies
    • ,,, et al.. ;:-
    • Chen J,Florian J,Carter W, et al.Earlier sustained virologic response end points for regulatory approval and dose selection of hepatitis C therapies.Gastroenterology. 2013;144:1450-5.e2
    • (2013) Gastroenterology , vol.144 , pp. 1450-1455
    • Chen, J.1    Florian, J.2    Carter, W.3
  • 15
    • 84923835686 scopus 로고    scopus 로고
    • Guidance for industry chronic hepatitis C virus infection: developing direct-acting antiviral drugs for treatment. Accessed November 29, 2014
    • Guidance for industry chronic hepatitis C virus infection: developing direct-acting antiviral drugs for treatment. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm225333.pdf. Accessed November 29, 2014.
  • 16
    • 84923835685 scopus 로고    scopus 로고
    • Concordance between SVR4, SVR12 and SVR24 in genotype 1 HCV-infected patients who received all oral fixed-dose combination ledipasvir/sofosbuvir with or without ribavirin in phase 3 clinical trials [abstract]
    • ,,, et al.. ;:-
    • Bernstein DE,Mangia A,Brau N, et al.Concordance between SVR4, SVR12 and SVR24 in genotype 1 HCV-infected patients who received all oral fixed-dose combination ledipasvir/sofosbuvir with or without ribavirin in phase 3 clinical trials [abstract].Hepatology (Baltimore, Md). 2014;60:1142A-1143A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1142-1143
    • Bernstein, D.E.1    Mangia, A.2    Brau, N.3
  • 17
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial
    • ,,, et al.. ;:-
    • Lawitz E,Poordad FF,Pang PS, et al.Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial.Lancet. 2014;383:515-523
    • (2014) Lancet , vol.383 , pp. 515-523
    • Lawitz, E.1    Poordad, F.F.2    Pang, P.S.3
  • 18
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • ,,, et al.. ;:-
    • Afdhal N,Zeuzem S,Kwo P, et al.Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.N Engl J Med. 2014;370:1889-1898
    • (2014) N Engl J Med , vol.370 , pp. 1889-1898
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3
  • 19
    • 84900326091 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
    • ,,, et al.. ;:-
    • Kowdley KV,Gordon SC,Reddy KR, et al.Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.N Engl J Med. 2014;370:1879-1888
    • (2014) N Engl J Med , vol.370 , pp. 1879-1888
    • Kowdley, K.V.1    Gordon, S.C.2    Reddy, K.R.3
  • 20
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • ,,, et al.. ;:-
    • Afdhal N,Reddy KR,Nelson DR, et al.Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection.N Engl J Med. 2014;370:1483-1493
    • (2014) N Engl J Med , vol.370 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.R.2    Nelson, D.R.3
  • 21
    • 84923835684 scopus 로고    scopus 로고
    • No differences in efficacy of fixed-dose combination ledipasvir/sofosbuvir in patients according to fibrosis stage development determined by liver biopsy or laboratory biomarker in phase 3 clinical trials [abstract]
    • ,,, et al.. ;:-
    • Gordon SC,Fried MW,Kwo P, et al.No differences in efficacy of fixed-dose combination ledipasvir/sofosbuvir in patients according to fibrosis stage development determined by liver biopsy or laboratory biomarker in phase 3 clinical trials [abstract].Hepatology (Baltimore, Md). 2014;60:1149A-1150A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1149-1150
    • Gordon, S.C.1    Fried, M.W.2    Kwo, P.3
  • 22
    • 84922479159 scopus 로고    scopus 로고
    • An integrated safety and efficacy analysis of >500 patients with compensated cirrhosis treated with ledipasvir/sofosbuvir with or without ribavirin [abstract]
    • ,,, et al
    • Bourliere M,Sulkowski M,Omata M, et al.An integrated safety and efficacy analysis of >500 patients with compensated cirrhosis treated with ledipasvir/sofosbuvir with or without ribavirin [abstract].Hepatology (Baltimore, Md). 2014;60:239A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 239
    • Bourliere, M.1    Sulkowski, M.2    Omata, M.3
  • 23
    • 84973272829 scopus 로고    scopus 로고
    • 100% SVR4 in Japanese patients with chronic genotype 1 hepatitis C virus infection receiving ledipasvir/sofosbuvir fixed dose combination for 12 weeks: results from a multicenter phase 3 study [abstract]
    • ,,, et al
    • Mizokami M,Takehara T,Yokosuka O, et al.100% SVR4 in Japanese patients with chronic genotype 1 hepatitis C virus infection receiving ledipasvir/sofosbuvir fixed dose combination for 12 weeks: results from a multicenter phase 3 study [abstract].Hepatology (Baltimore, Md). 2014;60:1130A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1130
    • Mizokami, M.1    Takehara, T.2    Yokosuka, O.3
  • 24
    • 84923835683 scopus 로고    scopus 로고
    • Gilead Sciences. Ledipasvir/sofosbuvir fixed-dose combination plus ribavirin in subjects with chronic HCV with advanced liver disease or post-liver transplant. Accessed November 29, 2014
    • Gilead Sciences. Ledipasvir/sofosbuvir fixed-dose combination plus ribavirin in subjects with chronic HCV with advanced liver disease or post-liver transplant. http://clinicaltrial.gov/ct2/show/NCT02010255?term=ledipasvir&rank=13. Accessed November 29, 2014.
  • 25
    • 84923835682 scopus 로고    scopus 로고
    • Gilead Sciences. Safety and efficacy of ledipasvir/sofosbuvir (LDV/SOF) fixed dose combination (FDC) for 12 or 24 weeks in kidney transplant recipients with chronic HCV infection. Accessed November 29, 2014
    • Gilead Sciences. Safety and efficacy of ledipasvir/sofosbuvir (LDV/SOF) fixed dose combination (FDC) for 12 or 24 weeks in kidney transplant recipients with chronic HCV infection. http://clinicaltrial.gov/ct2/show/NCT02251717?term=ledipasvir&rank=9. Accessed November 29, 2014.
  • 26
    • 84923839589 scopus 로고    scopus 로고
    • Early improvement in HepQuant (HQ)-SHUNT function test during treatment with ledipasvir/sofosbuvir in liver transplant recipients with allograft fibrosis or cirrhosis and patients with decompensated cirrhosis who have not undergone transplantation [abstract]
    • ,,, et al
    • O’Leary JG,Burton JR,Helmke SM, et al.Early improvement in HepQuant (HQ)-SHUNT function test during treatment with ledipasvir/sofosbuvir in liver transplant recipients with allograft fibrosis or cirrhosis and patients with decompensated cirrhosis who have not undergone transplantation [abstract].Hepatology (Baltimore, Md). 2014;60:1134A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1134
    • O’Leary, J.G.1    Burton, J.R.2    Helmke, S.M.3
  • 27
    • 84902497696 scopus 로고    scopus 로고
    • O14 Use of sofosbuvir/ledipasvir fixed dose combination for treatment of HCV genotype-1 in patients coinfected with HIV [abstract]
    • ,,, et al.. ; ():
    • Osinusi A,Townsend K,Nelson A, et al.O14 Use of sofosbuvir/ledipasvir fixed dose combination for treatment of HCV genotype-1 in patients coinfected with HIV [abstract].J Hepatol. 2014;60 (1): S7
    • (2014) J Hepatol , vol.60 , Issue.1 , pp. 7
    • Osinusi, A.1    Townsend, K.2    Nelson, A.3
  • 28
    • 84923845142 scopus 로고    scopus 로고
    • High efficacy of sofosbuvir/ledipasvir for the treatment of HCV genotype 1 in patients coinfected with HIV on or off antiretroviral therapy: results from the NIAID ERADICATE trial [abstract]
    • ,,, et al
    • Townsend K,Osinusi A,Nelson A, et al.High efficacy of sofosbuvir/ledipasvir for the treatment of HCV genotype 1 in patients coinfected with HIV on or off antiretroviral therapy: results from the NIAID ERADICATE trial [abstract].Hepatology (Baltimore, Md). 2014;60:240A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 240
    • Townsend, K.1    Osinusi, A.2    Nelson, A.3
  • 29
    • 84907525692 scopus 로고    scopus 로고
    • O6 Sofosbuvir/ledipasvir fixed dose combination is safe and effective in difficult-to-treat populations including genotype-3 patients, decompensated genotype-1 patients, and genotype-1 patients with prior sofosbuvir treatment experience [abstract]
    • ,,, et al.. ; (): -
    • Gane EJ,Hyland RH,An D, et al.O6 Sofosbuvir/ledipasvir fixed dose combination is safe and effective in difficult-to-treat populations including genotype-3 patients, decompensated genotype-1 patients, and genotype-1 patients with prior sofosbuvir treatment experience [abstract].J Hepatol. 2014;60 (1): S3-S4
    • (2014) J Hepatol , vol.60 , Issue.1 , pp. 3-4
    • Gane, E.J.1    Hyland, R.H.2    An, D.3
  • 30
    • 84920990853 scopus 로고    scopus 로고
    • Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with decompensated cirrhosis: preliminary results of a prospective, multicenter study [abstract]
    • ,,, et al.. ;:-
    • Flamm SJ,Everson GT,Charlton M, et al.Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with decompensated cirrhosis: preliminary results of a prospective, multicenter study [abstract].Hepatology (Baltimore, Md). 2014;60:320A-321A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 320-321
    • Flamm, S.J.1    Everson, G.T.2    Charlton, M.3
  • 31
    • 84923835681 scopus 로고    scopus 로고
    • Gilead Sciences. Efficacy and safety of ledipasvir/sofosbuvir fixed-dose combination in treatment-naïve and treatment-experienced subjects with chronic genotype 4 or 5 HCV infection. Accessed November 29, 2014
    • Gilead Sciences. Efficacy and safety of ledipasvir/sofosbuvir fixed-dose combination in treatment-naïve and treatment-experienced subjects with chronic genotype 4 or 5 HCV infection. http://clinicaltrial.gov/ct2/show/NCT02081079?-term=ledipasvir&rank=16. Accessed November 29, 2014.
  • 32
    • 84893741827 scopus 로고    scopus 로고
    • Once daily sofosbuvir/ledipasivr fixed dose combination with or without ribavirin: the ELECTRON trial [abstract]
    • ,,, et al
    • Gane EJ,Stedman CA,Hyland RH, et al.Once daily sofosbuvir/ledipasivr fixed dose combination with or without ribavirin: the ELECTRON trial [abstract].Hepatology (Baltimore, Md). 2013;58:243A
    • (2013) Hepatology (Baltimore, Md) , vol.58 , pp. 243
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 33
    • 84922477979 scopus 로고    scopus 로고
    • All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: interim results from the NIAID SYNERGY trial [abstract]
    • ,,, et al
    • Kapoor R,Kohli A,Sidharthan S, et al.All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: interim results from the NIAID SYNERGY trial [abstract].Hepatology (Baltimore, Md). 2014;60:321A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 321
    • Kapoor, R.1    Kohli, A.2    Sidharthan, S.3
  • 34
    • 84923835680 scopus 로고    scopus 로고
    • Gilead Sciences. Safety and efficacy of ledipasvir/sofosbuvir fixed dose combination in adolescents and children with chronic HCV-infection
    • Gilead Sciences. Safety and efficacy of ledipasvir/sofosbuvir fixed dose combination in adolescents and children with chronic HCV-infection. http://clinicaltrial.gov/ct2/show/NCT-02249182?term=ledipasvir&rank=6. Accessed November 29, 2014.
  • 35
    • 84913603634 scopus 로고    scopus 로고
    • O11 Retreatment of relapsers to sofosbuvir/ribavirin with sofosbuvir/ledipasvir: complete and rapid virologic suppression by week 4 [abstract]
    • ,,, et al.. ;:-
    • Osinusi A,Marti M,Townsend K, et al.O11 Retreatment of relapsers to sofosbuvir/ribavirin with sofosbuvir/ledipasvir: complete and rapid virologic suppression by week 4 [abstract].J Hepatol. 2014;60:S5-S6
    • (2014) J Hepatol , vol.60 , pp. 5-6
    • Osinusi, A.1    Marti, M.2    Townsend, K.3
  • 36
    • 84923852032 scopus 로고    scopus 로고
    • Retreatment of patients who failed prior sofobuvir-based regimens with all oral fixed-dose combination ledipasvir/sofosbuvir plus ribavirin for 12 weeks [abstract]
    • ,,, et al.. ;:-
    • Wyles DL,Pockros PJ,Yang C, et al.Retreatment of patients who failed prior sofobuvir-based regimens with all oral fixed-dose combination ledipasvir/sofosbuvir plus ribavirin for 12 weeks [abstract].Hepatology (Baltimore, Md). 2014;60:317A-318A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 317-318
    • Wyles, D.L.1    Pockros, P.J.2    Yang, C.3
  • 37
    • 84923845743 scopus 로고    scopus 로고
    • Ledipasvir/sofosbuvir is safe and effective in nosocomially infected patients with advanced age and significant cardiac co-morbidities [abstract]
    • ,,, et al
    • Chung RT,Lauer GM,Stamm LM, et al.Ledipasvir/sofosbuvir is safe and effective in nosocomially infected patients with advanced age and significant cardiac co-morbidities [abstract].Hepatology (Baltimore, Md). 2014;60:1158A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1158
    • Chung, R.T.1    Lauer, G.M.2    Stamm, L.M.3
  • 38
    • 84923838305 scopus 로고    scopus 로고
    • Virologic response rates to all oral fixed-dose combination ledipasvir/sofosbuvir regimens are similar in patients with and without traditional negative predictive factors in phase 3 clinical trials [abstract]
    • ,,, et al.. ;:-
    • Jacobson IM,Kwo P,Kowdley KV, et al.Virologic response rates to all oral fixed-dose combination ledipasvir/sofosbuvir regimens are similar in patients with and without traditional negative predictive factors in phase 3 clinical trials [abstract].Hepatology (Baltimore, Md). 2014;60:1141A-1142A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1141-1142
    • Jacobson, I.M.1    Kwo, P.2    Kowdley, K.V.3
  • 39
    • 84923835679 scopus 로고    scopus 로고
    • Drug-drug interaction profile of the fixed-dose combination tablet ledipasvir/sofosbuvir [abstract]
    • German P,Pang P,Fang L,Chung D,Mathias A.Drug-drug interaction profile of the fixed-dose combination tablet ledipasvir/sofosbuvir [abstract].Hepatology (Baltimore, Md). 2014;60:1162A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1162
    • German, P.1    Pang, P.2    Fang, L.3    Chung, D.4    Mathias, A.5
  • 40
    • 85027949450 scopus 로고    scopus 로고
    • Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-uninfected female subjects
    • German P,Moorehead L,Pang P,Vimal M,Mathias A.Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-uninfected female subjects.J Clin Pharmacol. 2014;54:1290-1298
    • (2014) J Clin Pharmacol , vol.54 , pp. 1290-1298
    • German, P.1    Moorehead, L.2    Pang, P.3    Vimal, M.4    Mathias, A.5
  • 41
    • 84923842285 scopus 로고    scopus 로고
    • Evaluation of the resistance profile of ledipasvir (LDV), a nonstructural protein 5A (NS5A) inhibitor, in genotype (GT) 1 chronically infected HCV subjects treated with LDV-containing regimens without sofosbuvir (SOF) [abstract]
    • ,,, et al.. ;:-
    • Kitrinos KM,Wyles DL,Dvory-Sobol H, et al.Evaluation of the resistance profile of ledipasvir (LDV), a nonstructural protein 5A (NS5A) inhibitor, in genotype (GT) 1 chronically infected HCV subjects treated with LDV-containing regimens without sofosbuvir (SOF) [abstract].Hepatology (Baltimore, Md). 2014;60:1143A-1144A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1143-1144
    • Kitrinos, K.M.1    Wyles, D.L.2    Dvory-Sobol, H.3
  • 42
    • 84923842585 scopus 로고    scopus 로고
    • Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir plus/minus RBV [abstract]
    • ,,, et al
    • Sarrazin C,Dvory-Sobol H,Svarovskaia E, et al.Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir plus/minus RBV [abstract].Hepatology (Baltimore, Md). 2014;60:1128A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1128
    • Sarrazin, C.1    Dvory-Sobol, H.2    Svarovskaia, E.3
  • 43
    • 84923835678 scopus 로고    scopus 로고
    • PollackA. Harvoni, a hepatitis C drug from Gilead, wins FDA approval
    • PollackA. Harvoni, a hepatitis C drug from Gilead, wins FDA approval. http://mobile.nytimes.com/2014/10/11/business/harvoni-a-hepatitis-c-drug-from-gilead-wins-fda-approval.html?_r=2&referrer=. Accessed November 29, 2014.
  • 44
    • 84923835677 scopus 로고    scopus 로고
    • LondeixP. New treatments for hepatitis C virus: strategies for achieving universal access. Accessed November 29, 2014
    • LondeixP. New treatments for hepatitis C virus: strategies for achieving universal access. http://www.hepcoalition.org/IMG/pdf/daas_strategies_for_achieving_universal_access_en.pdf. Accessed November 29, 2014.
  • 45
    • 84923848648 scopus 로고    scopus 로고
    • Evaluation of the long-term health outcomes of ledipasvir/sofosbuvir (LDV/SOF) and sofosbuvir-based regimens for patients with chronic hepatitis C (CHC) and liver cirrhosis across genotypes 1 to 4 (GT 1-4): results form a decision-analytic markov model [abstract]
    • Gordon SC,Ahmed A,Saab S,Younossi Z.Evaluation of the long-term health outcomes of ledipasvir/sofosbuvir (LDV/SOF) and sofosbuvir-based regimens for patients with chronic hepatitis C (CHC) and liver cirrhosis across genotypes 1 to 4 (GT 1-4): results form a decision-analytic markov model [abstract].Hepatology (Baltimore, Md). 2014;60:1040A-1041A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1040-1041
    • Gordon, S.C.1    Ahmed, A.2    Saab, S.3    Younossi, Z.4
  • 46
    • 84923842138 scopus 로고    scopus 로고
    • A decision-analytic markov model to evaluate the health outcomes of ledipasvir/sofosbuvir (LDV/SOF) for patients with chronic hepatitis C (HCV) genotype 1 (GT1) infection [abstract]
    • Younossi Z,Saab S,Ahmed A,Gordon SC.A decision-analytic markov model to evaluate the health outcomes of ledipasvir/sofosbuvir (LDV/SOF) for patients with chronic hepatitis C (HCV) genotype 1 (GT1) infection [abstract].Hepatology (Baltimore, Md). 2014;60:1043A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1043
    • Younossi, Z.1    Saab, S.2    Ahmed, A.3    Gordon, S.C.4
  • 47
    • 84923845937 scopus 로고    scopus 로고
    • Evaluation of the health outcomes for ledipasvir/sofosbuvir in early vs. delayed treatment according to fibrosis stage of patients with chronic hepatitis C virus (HCV) genotype 1 infection: results from a decision-analytic Markov model [abstract]
    • Ahmed A,Gordon SC,Saab S,Younossi Z.Evaluation of the health outcomes for ledipasvir/sofosbuvir in early vs. delayed treatment according to fibrosis stage of patients with chronic hepatitis C virus (HCV) genotype 1 infection: results from a decision-analytic Markov model [abstract].Hepatology (Baltimore, Md). 2014;60:1041A
    • (2014) Hepatology (Baltimore, Md) , vol.60 , pp. 1041
    • Ahmed, A.1    Gordon, S.C.2    Saab, S.3    Younossi, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.