Mitochondrial donation - How many women could benefit?

New England Journal of Medicine

Volumn 372, Issue 9, 2015, Pages 885-887

  Gorman, Gráinne S ^a   Grady, John P ^a   Turnbull, Doug M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA SEQUENCE; ETHNIC DIFFERENCE; FEMALE FERTILITY; FERTILIZATION IN VITRO; GOVERNMENT REGULATION; HETEROZYGOTE; HUMAN; LETTER; LICENSING; LIVE BIRTH; MUTATION RATE; PRIORITY JOURNAL; UNITED KINGDOM; UNITED STATES; ADOLESCENT; ADULT; BIRTH RATE; EPIDEMIOLOGY; FEMALE; FERTILITY; GENETICS; LEGISLATION AND JURISPRUDENCE; MITOCHONDRION; MUTATION; TRANSPLANTATION; YOUNG ADULT;

ADOLESCENT; ADULT; BIRTH RATE; DNA, MITOCHONDRIAL; FEMALE; FERTILITY; FERTILIZATION IN VITRO; GOVERNMENT REGULATION; GREAT BRITAIN; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUTATION; YOUNG ADULT;

EID: 84923830738     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1500960     Document Type: Letter

References (5)

1. Craven L, Tuppen HA, Greggains GD, et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 2010;465:82-5.
2. Tachibana M, Sparman M, Sritanaudomchai H, et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 2009;461:367-72.
3. Cohort fertility, England and Wales, 2012. London: Office for National Statistics, 2012 (http://www.ons.gov.uk/ons/rel/fertility-analysis/cohort-fertility-england-and-wales/2012/cohort-fertility-2012.html).
4. Births in England and Wales, 2013. London: Office for National Statistics, 2014 (http://www.ons.gov.uk/ons/rel/vsob1/birth-summary-tables-england-and-wales/2013/stb-births-in-england-and-wales-2013.html).
5. Monte LM, Ellis RR. Fertility of women in the United States: 2012. July 2014 (http://www.census.gov/content/dam/Census/library/publications/2014/demo/p20-575.pdf).