Transgenic Mouse Milk Expressing Human Bile Salt-Stimulated Lipase Improves the Survival and Growth Status of Premature Mice

Molecular Biotechnology

Volumn 57, Issue 3, 2015, Pages 287-297

  Wang, Yuanyuan ^a,b   Sheng, Zheya ^b,c   Wang, Yuhang ^b   Li, Qinghe ^b   Gao, Yu ^e   Wang, Yuhui ^d   Dai, Yunping ^b   Liu, George ^d   Zhao, Yaofeng ^b   Li, Ning ^b  

^a BENGBU MEDICAL COLLEGE   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^e Shun Da Kang Agricultural Science and Technology Development Co Ltd   (China)

Author keywords

Bile salt stimulated lipase; Mammary gland; Milk; Premature; Transgenic mice

Indexed keywords

ESTERS; MAMMALS; SALTS;

BILE SALTS; MAMMARY GLAND; MILK; PREMATURE; TRANSGENIC MICE;

DAIRIES;

BILE SALT; BILE SALT STIMULATED LIPASE; CHOLESTEROL; GLUCOSE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; CEL PROTEIN, HUMAN; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREAST MILK; CARBOHYDRATE METABOLISM; CHILD GROWTH; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FECES ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; LACTATION; LIPID ABSORPTION; LIPID ANALYSIS; LIPID METABOLISM; MALE; MOUSE; NEWBORN; NONHUMAN; PREMATURITY; SURVIVAL; TRIACYLGLYCEROL BLOOD LEVEL; WEANING; WEIGHT GAIN; ANIMAL; BIOLOGICAL MODEL; BLOOD; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; SECRETION (PROCESS); SURVIVAL RATE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; CHOLESTEROL; FEMALE; HUMANS; LIPASE; MALE; MICE; MICE, TRANSGENIC; MILK, HUMAN; MODELS, BIOLOGICAL; SURVIVAL RATE; TRIGLYCERIDES;

EID: 84923815159     PISSN: 10736085     EISSN: 15590305     Source Type: Journal    
DOI: 10.1007/s12033-014-9822-5     Document Type: Article

References (21)

1. Herrera, E., & Amusquivar, E. (2000). Lipid metabolism in the fetus and the newborn. Diabetes/Metabolism Research and Reviews,16(3), 202–210.
2. Stromqvist, M., Tornell, J., Edlund, M., Edlund, A., Johansson, T., Lindgren, K., et al. (1996). Recombinant human bile salt-stimulated lipase: An example of defective O-glycosylation of a protein produced in milk of transgenic mice. Transgenic Research,5(6), 475–485.
3. Hamosh, M. (1987). Lipid metabolism in premature infants. Biology of the Neonate,52(Suppl 1), 50–64.
4. Hui, D. Y., & Howles, P. N. (2002). Carboxyl ester lipase: Structure–function relationship and physiological role in lipoprotein metabolism and atherosclerosis. Journal of Lipid Research,43(12), 2017–2030.
5. Howles, P. N., Stemmerman, G. N., Fenoglio-Preiser, C. M., & Hui, D. Y. (1999). Carboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice. American Journal of Physiology,277(3 Pt 1), G653–G661.
6. Bläckberg, L., Duan, R. D., & Sternby, B. (1997). Purification of carboxyl ester lipase (bile salt-stimulated lipase) from human milk and pancreas. Methods in Enzymology,284, 185–194.
7. Sahasrabudhe, A. V., Solapure, S. M., Khurana, R., Suryanarayan, V., Ravishankar, S., deSousa, S. M., et al. (1998). Production of recombinant human bile salt stimulated lipase and its variant in Pichia pastoris. Protein Expression and Purification,14(3), 425–433.
8. Poorkhalkali, N., Lidmer, A. S., Lundberg, L. G., Dalrymple, M. A., Gibson, Y., Taylor, L., et al. (1998). Bile salt-stimulated lipase (BSSL) distribution in rat, mouse and transgenic mouse expressing human BSSL. Histochemistry and Cell Biology,110(4), 367–376.
9. Howles, P. N., Carter, C. P., & Hui, D. Y. (1996). Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. Journal of Biological Chemistry,271(12), 7196–7202.
10. Weng, W., Li, L., van Bennekum, A. M., Potter, S. H., Harrison, E. H., Blaner, W. S., et al. (1999). Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice. Biochemistry,38(13), 4143–4149.
11. Loctin, J., & Delost, P. (1983). Somatic development in premature mice from birth to weaning. Reproduction, Nutrition, Development,23(5), 915–926.
12. Hernell, O., & Olivecrona, T. (1974). Human milk lipases. I. Serum stimulated lipase. Journal of Lipid Research,15(4), 367–374.
13. Yu, S., Liang, M., Fan, B., Xu, H., Li, C., Zhang, Q., et al. (2006). Maternally derived recombinant human anti-hantavirus monoclonal antibodies are transferred to mouse offspring during lactation and neutralize virus in vitro. Journal of Virology,80(8), 4183–4186.
14. Zhang, R., Rao, M., Li, C., Cao, J., Meng, Q., Zheng, M., et al. (2009). Functional recombinant human anti-HAV antibody expressed in milk of transgenic mice. Transgenic Research,18(3), 445–453.
15. Wang, Y., Tong, J., Li, S., Zhang, R., Chen, L., Wang, Y., et al. (2011). Over-expression of human lipoprotein lipase in mouse mammary glands leads to reduction of milk triglyceride and delayed growth of suckling pups. PLoS ONE,6(6), e20895.
16. Miller, R., & Lowe, M. E. (2008). Carboxyl ester lipase from either mother’s milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. Journal of Nutrition,138(5), 927–930.
17. Lombardo, D. (2001). Bile salt-dependent lipase: Its pathophysiological implications. Biochimica et Biophysica Acta,1533(1), 1–28.
18. Andersson, E. L., Hernell, O., Blackberg, L., Falt, H., & Lindquist, S. (2011). Bile salt-stimulated lipase and pancreatic lipase-related protein 2: Key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line. Journal of Lipid Research,52(11), 1949–1956.
19. Wang, C. S., Martindale, M. E., King, M. M., & Tang, J. (1989). Bile-salt-activated lipase: Effect on kitten growth rate. American Journal of Clinical Nutrition,49(3), 457–463.
20. Li, X., Lindquist, S., Lowe, M., Noppa, L., & Hernell, O. (2007). Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats. Pediatric Research,62(5), 537–541.
21. Pamblanco, M., Ten, A., & Comin, J. (1987). Bile salt-stimulated lipase activity in human colostrum from mothers of infants of different gestational age and birthweight. Acta Paediatrica Scand,76(2), 328–331.