Assessment of aminoglycoside dosing and estimated glomerular filtration rate in determining gentamicin and tobramycin area under the curve and clearance

Internal Medicine Journal

Volumn 45, Issue 3, 2015, Pages 319-329

  Lim, A K H ^a   Mathanasenarajah, G ^a   Larmour, I ^a  

^a SOUTHERN HEALTH   (Australia)

Author keywords

Aminoglycoside clearance; Antibiotic guideline; Cockroft Gault; Estimated glomerular filtration rate; Gentamicin; Tobramycin

Indexed keywords

AMIKACIN; CREATININE; GENTAMICIN; TOBRAMYCIN; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BODY SURFACE; BODY WEIGHT; COMPARTMENT MODEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG CLEARANCE; DRUG EXPOSURE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; TREATMENT DURATION; ADOLESCENT; AGED; DOSE RESPONSE; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENTAMICINS; GLOMERULAR FILTRATION RATE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; TOBRAMYCIN; YOUNG ADULT;

EID: 84923763092     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/imj.12684     Document Type: Article

References (25)

1. Antibiotics Expert Group. Monitoring Antimicrobial Blood Concentrations and Aminoglycoside and Vancomycin Dosing. Therapeutic Guidelines: Antibiotics, version 14. Melbourne: Therapeutic Guidelines Limited; 2010; 357-362.
2. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int 2011; 79: 33-45.
3. Pagkalis S, Mantadakis E, Mavros MN, Ammari C, Falagas ME. Pharmacological considerations for the proper clinical use of aminoglycosides. Drugs 2011; 71: 2277-2294.
4. Avent ML, Rogers BA, Cheng AC, Paterson DL. Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity. Intern Med J 2011; 41: 441-449.
5. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S etal. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145: 247-254.
6. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI etal. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.
7. Golik MV, Lawrence KR. Comparison of dosing recommendations for antimicrobial drugs based on two methods for assessing kidney function: Cockcroft-Gault and modification of diet in renal disease. Pharmacotherapy 2008; 28: 1125-1132.
8. Hermsen ED, Maiefski M, Florescu MC, Qiu F, Rupp ME. Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacotherapy 2009; 29: 649-655.
9. Wargo KA, English TM. Evaluation of the chronic kidney disease epidemiology collaboration equation for dosing antimicrobials. Ann Pharmacother 2010; 44: 439-446.
10. Gill J, Malyuk R, Djurdjev O, Levin A. Use of GFR equations to adjust drug doses in an elderly multi-ethnic group: a cautionary tale. Nephrol Dial Transplant 2007; 22: 2894-2899.
11. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG etal. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31.
12. Turnidge J, Bell J Target AUC values. Aladdin Manual Version 4.0. 2010: 9.
13. Jelliffe RW, Iglesias T, Hurst AK, Foo KA, Rodriguez J. Individualising gentamicin dosage regimens. A comparative review of selected models, data fitting methods and monitoring strategies. Clin Pharmacokinet 1991; 21: 461-478.
14. Xuan D, Nicolau DP, Nightingale CH. Population pharmacokinetics of gentamicin in hospitalized patients receiving once-daily dosing. Int J Antimicrob Agents 2004; 23: 291-295.
15. Chin PK, Florkowski CM, Begg EJ. The performances of the Cockcroft-Gault, modification of diet in renal disease study and chronic kidney disease epidemiology collaboration equations in predicting gentamicin clearance. Ann Clin Biochem 2013; 50(Pt 6): 546-557.
16. Pai MP, Nafziger AN, Bertino JS Jr. Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients. Antimicrob Agents Chemother 2011; 55: 4006-4011.
17. Zarowitz BJ, Robert S, Peterson EL. Prediction of glomerular filtration rate using aminoglycoside clearance in critically ill medical patients. Ann Pharmacother 1992; 26: 1205-1210.
18. Kirkpatrick CM, Duffull SB, Begg EJ. Pharmacokinetics of gentamicin in 957 patients with varying renal function dosed once daily. Br J Clin Pharmacol 1999; 47: 637-643.
19. Charhon N, Neely MN, Bourguignon L, Maire P, Jelliffe RW, Goutelle S. Comparison of four renal function estimation equations for pharmacokinetic modeling of gentamicin in geriatric patients. Antimicrob Agents Chemother 2012; 56: 1862-1869.
20. Ryzner KL. Evaluation of aminoglycoside clearance using the modification of diet in renal disease equation versus the Cockcroft-Gault equation as a marker of glomerular filtration rate. Ann Pharmacother 2010; 44: 1030-1037.
21. Bookstaver PB, Johnson JW, McCoy TP, Stewart D, Williamson JC. Modification of diet in renal disease and modified Cockcroft-Gault formulas in predicting aminoglycoside elimination. Ann Pharmacother 2008; 42: 1758-1765.
22. Al-Aloul M, Miller H, Alapati S, Stockton PA, Ledson MJ, Walshaw MJ. Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use. Pediatr Pulmonol 2005; 39: 15-20.
23. Alghanem S, Paterson I, Touw DJ, Thomson AH. Influence of multiple courses of therapy on aminoglycoside clearance in adult patients with cystic fibrosis. J Antimicrob Chemother 2013; 68: 1338-1347.
24. Schentag JJ, Plaut ME, Cerra FB. Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients. Antimicrob Agents Chemother 1981; 19: 859-866.
25. Donta ST, Lembke LA. Comparative effects of gentamicin and tobramycin on excretion of N-acetyl-beta-D-glucosaminidase. Antimicrob Agents Chemother 1985; 28: 500-503.