Chemotherapy of respiratory syncytial virus infections: The final breakthrough

International Journal of Antimicrobial Agents

Volumn 45, Issue 3, 2015, Pages 234-237

  De Clercq, Erik ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

GS 5806; Palivizumab; Respiratory syncytial virus; Ribavirin; RSV; Virus cell fusion

Indexed keywords

ANTIVIRUS AGENT; ASVASIRAN; F GLYCOPROTEIN; GS 5806; HYBRID PROTEIN; NEUTRALIZING ANTIBODY; PALIVIZUMAB; PLACEBO; RIBAVIRIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; GS-5806; PYRAZOLE DERIVATIVE; SULFONAMIDE;

CELL FUSION; DRUG COST; DRUG EFFICACY; DRUG STRUCTURE; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; LOWER RESPIRATORY TRACT INFECTION; MORTALITY; PARAMYXOVIRIDAE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RESPIRATORY FAILURE; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVIEW; RISK FACTOR; RNA INTERFERENCE; SEASONAL INFLUENZA; VIRAL GENETICS; VIRUS LOAD; VIRUS STRAIN; WHEEZING; INHALATIONAL DRUG ADMINISTRATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ANTIVIRAL AGENTS; HUMANS; PYRAZOLES; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RIBAVIRIN; SULFONAMIDES; TREATMENT OUTCOME;

EID: 84923650187     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2014.12.025     Document Type: Review

References (26)

1. E. De Clercq Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections Int J Antimicrob Agents 7 1996 193 202
2. C.B. Hall, G.A. Weinberg, M.K. Iwane, A.K. Blumkin, K.M. Edwards, and M.A. Staat The burden of respiratory syncytial virus infection in young children N Engl J Med 360 2009 588 598
3. H. Nair, D.J. Nokes, B.D. Gessner, M. Dherani, S.A. Madhi, and R.J. Singleton Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Lancet 375 2010 1545 1555
4. J.P. DeVincenzo, R.J. Whitley, R.L. Mackman, C. Scaglioni-Weinlich, L. Harrison, and E. Farrell Oral GS-5806 activity in a respiratory syncytial virus challenge study N Engl J Med 371 2014 711 722
5. P.F. Wright Progress in the prevention and treatment of RSV infection N Engl J Med 371 2014 776 777
6. T.S. Jardetzky, and R.A. Lamb Activation of paramyxovirus membrane fusion and virus entry Curr Opin Virol 5 2014 24 33
7. J.S. McLellan, M. Chen, M.G. Joyce, M. Sastry, G.B. Stewart-Jones, and Y. Yang Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus Science 342 2013 592 598
8. W.W. Thompson, D.K. Shay, E. Weintraub, L. Brammer, N. Cox, and L.J. Anderson Mortality associated with influenza and respiratory syncytial virus in the United States JAMA 289 2003 179 186
9. M.O. Blanken, M.M. Rovers, J.M. Molenaar, P.L. Winkler-Seinstra, A. Meijer, and J.L. Kimpen Dutch RSV Neonatal Network. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants N Engl J Med 368 2013 1791 1799
10. S. Seo, A.P. Campbell, H. Xie, J.W. Chien, W.M. Leisenring, and J.A. Englund Outcome of respiratory syncytial virus lower respiratory tract disease in hematopoietic cell transplant recipients receiving aerosolized ribavirin: significance of stem cell source and oxygen requirement Biol Blood Marrow Transplant 19 2013 589 596
11. A. Waghmare, A.P. Campbell, H. Xie, S. Seo, J. Kuypers, and W. Leisenring Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes Clin Infect Dis 57 2013 1731 1741
12. A.R. Falsey, P.A. Hennessey, M.A. Formica, C. Cox, and E.E. Walsh Respiratory syncytial virus infection in elderly and high-risk adults N Engl J Med 352 2005 1749 1759
13. N. Lee, G.C. Lui, K.T. Wong, T.C. Li, E.C. Tse, and J.Y. Chan High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections Clin Infect Dis 57 2013 1069 1077
14. K. Widmer, Y. Zhu, J.V. Williams, M.R. Griffin, K.M. Edwards, and H.K. Talbot Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults J Infect Dis 206 2012 56 62
15. J.R. Romero Palivizumab prophylaxis of respiratory syncytial virus disease from 1998 to 2002: results from four years of palivizumab usage Pediatr Infect Dis J 22 Suppl. 2003 S46 S54
16. Committee on Infectious Diseases From the American Academy of Pediatrics: Policy statements - Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections Pediatrics 124 2009 1694 1701
17. T. Andabaka, J.W. Nickerson, M.X. Rojas-Reyes, J.D. Rueda, V. Bacic Vrca, and B. Barsic Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children Cochrane Database Syst Rev 4 2013 CD006602
18. S. Joffe, G.T. Ray, G.J. Escobar, S.B. Black, and T.A. Lieu Cost-effectiveness of respiratory syncytial virus prophylaxis among preterm infants Pediatrics 104 1999 419 427
19. C.B. Hall, G.A. Weinberg, A.K. Blumkin, K.M. Edwards, M.A. Staat, and A.F. Schultz Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age Pediatrics 132 2013 e341 e348
20. K. Ventre, and A.G. Randolph Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children Cochrane Database Syst Rev 1 2007 CD000181
21. J. DeVincenzo, R. Lambkin-Williams, T. Wilkinson, J. Cehelsky, S. Nochur, and E. Walsh A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus Proc Natl Acad Sci USA 107 2010 8800 8805
22. E.E. Walsh, D.R. Peterson, A.E. Kalkanoglu, F.E. Lee, and A.R. Falsey Viral shedding and immune responses to respiratory syncytial virus infection in older adults J Infect Dis 207 2013 1424 1432
23. M.L. Houben, F.E. Coenjaerts, J.W. Rossen, M.E. Belderbos, R.W. Hofland, and J.L. Kimpen Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community J Med Virol 82 2010 1266 1271
24. B. Bagga, C.W. Woods, T.H. Veldman, A. Gilbert, A. Mann, and G. Balaratnam Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals Antivir Ther 18 2013 785 791
25. J.P. DeVincenzo, T. Wilkinson, A. Vaishnaw, J. Cehelsky, R. Meyers, and S. Nochur Viral load drives disease in humans experimentally infected with respiratory syncytial virus Am J Respir Crit Care Med 182 2010 1305 1314
26. C.M. El Saleeby, A.J. Bush, L.M. Harrison, J.A. Aitken, and J.P. Devincenzo Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children J Infect Dis 204 2011 996 1002