Potential drug interaction between warfarin and linezolid

Internal Medicine

Volumn 54, Issue 5, 2015, Pages 459-464

  Sakai, Yoshiro ^a,b   Naito, Tetsuya ^a   Arima, Chiyoko ^a   Miura, Miho ^a   Qin, Liang ^b   Hidaka, Hidenobu ^a,b   Masunaga, Kenji ^a,b   Kakuma, Tatsuyuki ^b   Watanabe, Hiroshi ^a,b  

^a KURUME UNIVERSITY HOSPITAL   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Drug interaction; Linezolid; PT INR; Warfarin

Indexed keywords

LINEZOLID; RIFAMPICIN; VITAMIN K GROUP; WARFARIN; ACETAMIDE DERIVATIVE; ANTICOAGULANT AGENT; ANTIINFECTIVE AGENT; OXAZOLIDINONE DERIVATIVE;

ADULT; AGED; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTICOAGULANT THERAPY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG INTERACTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENDOCARDITIS; FEMALE; HEART VALVE REPLACEMENT; HUMAN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PROTHROMBIN TIME; RETROSPECTIVE STUDY; STREPTOCOCCUS CONSTELLATUS; VALVULOPLASTY; BLOOD; DRUG POTENTIATION; INTERNATIONAL NORMALIZED RATIO; MIDDLE AGED; TIME;

ACETAMIDES; AGED; ANTI-INFECTIVE AGENTS; ANTICOAGULANTS; DRUG SYNERGISM; FEMALE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; OXAZOLIDINONES; PROTHROMBIN TIME; RETROSPECTIVE STUDIES; TIME FACTORS; WARFARIN;

EID: 84923644139     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.54.3146     Document Type: Article

References (12)

1. Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 30: 10363-10370, 1991.
2. Eisai Co. Interview form. Warfarin Tablets. [Internet]. [cited 2014 Mar 25]. Available from: http://www.info.pmda.go.jp/
3. Pfizer Co. Interview form. Zyvox Injection. [Internet]. [cited 2014 Mar 25]. Available from: http://www.info.pmda.go.jp/
4. Wiskirchen DE, Shepard A, Kuti JL, et al. Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis. Antimicrob Agents Chemother 55: 4170-4175, 2011.
5. Liu C, Bayer A, Cosgrove SE, et al. Infectious Diseases Society of America.Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 52: e18-e55, 2011.
6. Baillargeon J, Holmes HM, Lin YL, et al. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Am J Med 125: 183-189, 2012.
7. Stalker DJ, Jungbluth GL. Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial. Clin Pharmacokinet 42: 1129-1140, 2003.
8. Abdelhafiz AH, Myint MP, Tayek JA, et al. Anemia, hypoalbuminemia, and renal impairment as predictors of bleeding complications in patients receiving anticoagulation therapy for nonvalvular atrial fibrillation: a secondary analysis. Clin Ther 31: 1534-1539, 2009.
9. DiMarco JP, Flaker G, Waldo AL, et al; AFFIRM Investigators. Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 149: 650-656, 2005.
10. Slatter JG, Stalker DJ, Feenstra KL, et al. Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects. Drug Metab Dispos 29: 1136-1145, 2001.
11. Moubareck C, Gavini F, Vaugien L, et al. Antimicrobial susceptibility of bifidobacteria. J Antimicrob Chemother 55: 38-44, 2005.
12. Lee CR, Thrasher KA. Difficulties in anticoagulation management during coadministration of warfarin and rifampin. Pharmacotherapy 21: 1240-1246, 2001.