Lack of detectable allergenicity in genetically modified maize containing "cry" proteins as compared to native maize based on in silico & in vitro analysis

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Mathur, Chandni ^a   Kathuria, Pooran C ^b   Dahiya, Pushpa ^c   Singh, Anand B ^a  

^a UNIVERSITY OF DELHI   (India)

^b National Allergy Centre   (India)

^c MAHARSHI DAYANAND UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CRY1AB TOXIN; CRY1AC TOXIN; CRY1C TOXIN; IMMUNOGLOBULIN E; UNCLASSIFIED DRUG; ALLERGEN; PLANT PROTEIN;

ADULT; ALLERGENICITY; ANTIGEN BINDING; ARTICLE; BACILLUS THURINGIENSIS; BIOINFORMATICS; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; FOOD ALLERGY; HUMAN; IMMUNOBLOTTING; IN VITRO STUDY; MAIZE; MALE; MIDDLE AGED; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DATABASE; QUALITATIVE ANALYSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIMULATION; STOMACH JUICE; TRANSGENIC PLANT; YOUNG ADULT; COMPUTER SIMULATION; GENETICALLY MODIFIED FOOD; GENETICS; METABOLISM;

SIGE; ZEA MAYS;

ALLERGENS; COMPUTER SIMULATION; FOOD, GENETICALLY MODIFIED; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; ZEA MAYS;

EID: 84923600798     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117340     Document Type: Article

References (41)

1. Goodman RE, Affua OT (2011) Suggested Improvements for the Allergenicity Assessment of Genetically modified Plants used in foods. Curr Allergy Asthma Rep 11: 317-324. doi: 10.1007/s11882-011-0195-6 PMID: 21487714
2. Hileman RE, Silvanovich A, Goodman RE, Rice EA, Holleschak G, et al. (2002) Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Int Arch Allergy Immunol 128: 280-291. PMID: 12218366
3. Bates SL, Zhao JZ, Roush RT, Shelton AM (2005) Insect resistance management in GM crops: past, present and future. Nat Biotechnol 23: 57-62. PMID: 15637622
4. James C (2011) Global Status of Commercialized Biotech/GM Crops. ISAAA Brief No. 43. ISAAA: Ithaca, NY.
5. Metcalfe DD, Astwood JD, Townsend R, Sampson HA, Taylor SL et al. (1996) Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr 36: 165-186. PMID: 8959382
6. Food and Agriculture Organization/World Health Organization, FAO/WHO (2001) Evaluation of the Allergenicity of Genetically Modified foods: Report of a Joint FAO/WHO Expert Consultation, 22-25 January, Rome, Italy. Available: http://www.fao.org/docrep/007/y0820e/y0820e00.HTM.
7. th Session, 30 June-5 July, Rome, Italy. pp 47-60. Available- http://www.fao.org/fileadmin/user-upload/gmfp/resources/al03-34e.pdf
8. OECD (1998) Report of the Organization for Economic Cooperation and Development Workshop on the Toxicological and Nutritional Testing of Novel Foods, 5-8 March 1997, Aussois, France. http://www.oecd.org/env/ehs/biotrack/SG-ICGB%2898%291-FINAL-ENG%20-Novel-Foods-Aussoisreport.pdf
9. ICMR (2008) Indian Council of Medical Research, guidelines for safety assessment of food derived from Genetically Engineered Plants. Available: http://www.icmr.nic.in/guide/Guidelines%20for%20Genetically%20Engineered%20Plants.pdf (updated 2012).
10. Ladics GS, Cressman RF, Guicheney CH, Herman RA, Privalle L et al. (2011) Bioinformatics and the allergy assessment of agricultural biotechnology products: Industry practices and recommendations. Regul Toxicol Pharmacol 60: 46-53. doi: 10.1016/j.yrtph.2011.02.004 PMID: 21320564
11. FAO (1995) Report of the FAO technical consultation on food allergies, 13-14 November, Rome, Italy. Food and Agriculture Organization of the United Nations.
12. Sicherer SH, Sampson HA (2014) Food allergy: Epidemiology, pathogenesis, diagnosis and treatment. J Allergy Clin Immunol 133: 291-307. doi: 10.1016/j.jaci.2013.11.020 PMID: 24388012
13. Prescott SL, Pawankar R, Allen KJ, Campbell DE, Sinn J Kh, et al. (2013) A global survey of changing patterns of food allergy burden in children. World Allergy Organ J 6: 1939-4551.
14. Panda R, Ariyarathna H, Amnuaycheewa P, Tetteh A, Pramod SN, et al. (2013) Challenges in testing genetically modified crops for potential increases in endogenous allergen expression for safety. Allergy 68: 142-151. doi: 10.1111/all.12076 PMID: 23205714
15. Satoh R, Nakamura R, Komatsu A, Oshima M, Teshima R (2011) Proteomic analysis of known and candidate rice allergens between nontransgenic and transgenic plants. Regul Toxicol Pharmacol 59: 437-444. doi: 10.1016/j.yrtph.2011.01.008 PMID: 21300107
16. Ivanciuc O, Schein CH, Braun W (2003) SDAP: database and computational tools for allergenic proteins. Nucleic Acids Res 31: 359-362. PMID: 12520022
17. Henikoff S, Henikoff JG (1992) Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA 89: 10915-10919. PMID: 1438297
18. Kasera R, Singh BP, Lavasa S, Prasad KN, Sahoo RC, et al. (2011) Kidney Bean: A Major Sensitizer among Legumes in Asthma and Rhinitis Patients from India. PLoS ONE 6(11): e27193. doi: 10.1371/journal.pone.0027193 PMID: 22096535
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin Phenol reagent. J Biol Chem 193: 265-275. PMID: 14907713
20. Lammeli UK (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227: 680-685. PMID: 5432063
21. Astwood JD, Leach JN, Fuchs RL (1996) Stability of food allergens to digestion in vitro. Nat Biotechnol 14: 1269-1273. PMID: 9631091
22. Ofori Anti AO, Ariyarathna H, Chen L, Lee HL, Pramod SN, et al. (2008) Establishing objective detection limits for the pepsin digestion assay used in the assessment of genetically modified foods. Regul Toxicol Pharmacol 52: 94-103. doi: 10.1016/j.yrtph.2008.06.006 PMID: 18611423
23. United States Pharmacopeia Convention, Committee of Revision (1989) The United States Pharmacopeia; The National Formulary. Vol. XXII, NF XVII, p 1788.
24. Sepulveda R, Longbottom JL, Pepys J (1979) Enzyme linked immunosorbent assay (ELISA) for IgG and IgE antibodies to protein and polysaccharides antigens of Aspergillus fumigatus. Clin Allergy 9: 359-371. PMID: 113131
25. Kauffman HF, Beaumont F, Meurs H, Heidi SV, de Vries K (1983) Comparison of antibody measurement against Aspergillus fumigatus by means of double - diffusion and enzyme linked immunosorbent assay (ELISA). J Allergy Clin Immunol 72: 255-261. PMID: 6411795
26. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354. PMID: 388439
27. Aalberse RC (2000) Structural biology of allergens. J Allergy Clin Immunol 106: 228-238. PMID: 10932064
28. Dhillon BS, Prasanna BM (2001) Maize in breeding food crops, Chopra VL, editor Oxford & IBH, New Delhi. pp147-185.
29. IGMORIS. Indian GMO Research Information System, Document on Biology of Maize. Department of Biotechnology, Govt. of India. Available: http://igmoris.nic.in/Files2/BiologyDocuments/Biology-of-Maize.pdf
30. Knowles BH (1994) Mechanism of action of Bacillus thurigenesis insecticidal delta endotoxins. Adv In Insect Physiol 24: 275-308.
31. Batista R, Nunes B, Cardoso C, Jose HS, Almeida AB, et al. (2005) Lack of detectable allergenicity of transgenic maize and soya samples. J Allergy Clin Immunol 116: 403-410. PMID: 16083797
32. Buzoianu SG, Walsh MC, Rea MC, O'Donovan O, Gelencsér E, et al. (2012) Effects of Feeding Bt Maize to Sows during Gestation and Lactation on Maternal and Offspring Immunity and Fate of Transgenic Material. PLoS ONE 7(10): e47851. doi: 10.1371/journal.pone.0047851 PMID: 23091650
33. Walsh MC, Buzoianu SG, Gardiner GE, Rea MC, Gelencsér E, et al. (2011) Fate of Transgenic DNA from Orally Administered Bt MON810 Maize and Effects on Immune Response and Growth in Pigs. PLoS ONE 6(11): e27177. doi: 10.1371/journal.pone.0027177 PMID: 22132091
34. Verma AK, Mishra A, Subash S, Das M, Dwivedi PD (2011) Computational allergenicity prediction of transgenic proteins expressed in genetically modified crops. Immunopharmacol Immunotoxicol 33: 410-422. doi: 10.3109/08923973.2010.523704 PMID: 20964517
35. Randhawa GJ, Singh M, Grover M (2011) Bioinformatic analysis for allergenicity assessment of Bacillus thuringiensis Cry proteins expressed in insect-resistant food crops. Food Chem Toxicol 49: 356-362. doi: 10.1016/j.fct.2010.11.008 PMID: 21078358
36. Melinda CM, Keshun L, William AT, Raymond CD (2005) Glyphosate-Tolerant Soybeans Remain Compositionally Equivalent to Conventional Soybeans (Glycine max L.) during Three Years of Field Testing. J Agric Food Chem 53: 5331-5335. PMID: 15969514
37. Noteborn HPJM Bienenmann Ploum ME, van den Berg JHJ, Alink GM, Zolla L, et al. (1995) Safety Assessment of the Bacillus thuringiensis Insecticidal Crystal Protein CRYIA(b) Expressed in Transgenic Tomatoes. American Chemical Society Symposium Series, pp 134-147.
38. Burks AW, Fuchs RL (1995) Assessment of the endogenous allergens in glyphosate tolerant and commercial soybean varieities. J Allergy Clin Immunol 96: 1008-1010. PMID: 8543735
39. Taylor SL (1997) Foods from genetically modified organisms and potential for food allergy. Environ Toxicol Pharmacol 4: 121-126. PMID: 21781810
40. Pastorello EA, Farioli L, Pravettoni V, Ispano M, Scibola E, et al. (2000) The major Maize allergen, which is responsible for food induced allergic reactions, is a lipid transfer protein. J Allergy Clin Immunol 106: 744-751. PMID: 11031346
41. Fasoli E, Pastorello EA, Farioli L, Scibilia J, Aldini G, et al. (2009) Searching for allergens in maize kernels via proteomic tools. J Proteomics 72: 501-510. PMID: 19367736