Model scenarios for switch-like mitotic transitions

FEBS Letters

Volumn 589, Issue 6, 2015, Pages 667-671

  Vinod, P K ^a,b   Novak, Bela ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INTERNATIONAL INSTITUTE OF INFORMATION TECHNOLOGY   (India)

Author keywords

Biochemical kinetics; Bistability; Greatwall kinase; Mitotic control; Phosphatase

Indexed keywords

CYCLIN DEPENDENT KINASE 1; CDK1 PROTEIN, HUMAN; CYCLIC AMP-REGULATED PHOSPHOPROTEIN 19; CYCLIN DEPENDENT KINASE; ENDOSULFINE; PEPTIDE; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2;

ARTICLE; AUTOREGULATION; BIOACCUMULATION; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; FEEDBACK SYSTEM; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MITOSIS RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; XENOPUS; ALGORITHM; BIOLOGICAL MODEL; HUMAN; MITOSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ALGORITHMS; CYCLIN-DEPENDENT KINASES; FEEDBACK, PHYSIOLOGICAL; HUMANS; MITOSIS; MODELS, BIOLOGICAL; PEPTIDES; PHOSPHOPROTEINS; PROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCTION;

EID: 84923565307     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.02.007     Document Type: Article

References (16)

1. P.V. Castilho, B.C. Williams, S. Mochida, Y. Zhao, and M.L. Goldberg The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites Mol. Biol. Cell 20 22 2009 4777 4789
2. M.J. Cundell, R.N. Bastos, T. Zhang, J. Holder, U. Gruneberg, B. Novak, and F.A. Barr The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation Mol. Cell 52 3 2013 393 405 10.1016/j.molcel.2013.09.005
3. A. Gharbi-Ayachi, J.C. Labbe, A. Burgess, S. Vigneron, J.M. Strub, E. Brioudes, A. Van-Dorsselaer, A. Castro, and T. Lorca The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A Science 330 6011 2010 1673 1677
4. A. Goldbeter, C. Gerard, D. Gonze, J.C. Leloup, and G. Dupont Systems biology of cellular rhythms FEBS Lett. 586 18 2012 2955 2965 10.1016/j.febslet.2012.07.041
5. P. Gravells, K. Tomita, A. Booth, J. Poznansky, and A.C. Porter Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle Hum. Mol. Genet. 22 14 2013 2842 2851 10.1093/hmg/ddt133
6. N. Hegarat, C. Vesely, P.K. Vinod, C. Ocasio, N. Peter, J. Gannon, A.W. Oliver, B. Novak, and H. Hochegger PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit PLoS Genet. 10 1 2014 e1004004 10.1371/journal.pgen.1004004
7. M. Koivomagi, E. Valk, R. Venta, A. Iofik, M. Lepiku, E.R. Balog, S.M. Rubin, D.O. Morgan, and M. Loog Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase Nature 480 7375 2011 128 131 10.1038/nature10560
8. S. Mochida, S. Ikeo, J. Gannon, and T. Hunt Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts EMBO J. 28 18 2009 2777 2785
9. S. Mochida, S.L. Maslen, M. Skehel, and T. Hunt Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis Science 330 6011 2010 1670 1673
10. T.Y. Tsai, J.A. Theriot, and J.E. Ferrell Jr. Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos PLoS Biol. 12 2 2014 e1001788 10.1371/journal.pbio.1001788
11. J.J. Tyson, K. Chen, and B. Novak Network dynamics and cell physiology Nat. Rev. Mol. Cell Biol. 2 12 2001 908 916
12. A. Verdugo, P.K. Vinod, J.J. Tyson, and B. Novak Molecular mechanisms creating bistable switches at cell cycle transitions Open Biol. 3 3 2013 120179 10.1098/rsob.120179
13. S. Vigneron, E. Brioudes, A. Burgess, J.C. Labbe, T. Lorca, and A. Castro Greatwall maintains mitosis through regulation of PP2A EMBO J. 28 18 2009 2786 2793
14. B.C. Williams, J.J. Filter, K.A. Blake-Hodek, B.E. Wadzinski, N.J. Fuda, D. Shalloway, and M.L. Goldberg Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers Elife 3 2014 e01695 10.7554/eLife. 01695
15. J.Q. Wu, J.Y. Guo, W. Tang, C.S. Yang, C.D. Freel, C. Chen, A.C. Nairn, and S. Kornbluth PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation Nat. Cell Biol. 11 5 2009 644 651
16. J. Yu, Y. Zhao, Z. Li, S. Galas, and M.L. Goldberg Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts Mol. Cell 22 1 2006 83 91