Successful catheter ablation decreases platelet activation and improves endothelial function in patients with atrial fibrillation

Heart Rhythm

Volumn 11, Issue 11, 2014, Pages 1912-1918

  Lim, Han S ^a   Willoughby, Scott R ^a   Schultz, Carlee ^a   Chakrabarty, Adhiraj ^a   Alasady, Muayad ^a   Lau, Dennis H ^a   Roberts Thomson, Kurt C ^a   Worthley, Matthew I ^a   Young, Glenn D ^a   Sanders, Prashanthan ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Atrial fibrillation; Catheter ablation; Endothelial dysfunction; Platelet activation; Stroke prevention; Thrombotic risk

Indexed keywords

AMIODARONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DUAL SPECIFICITY PHOSPHATASE 2; ENOXAPARIN; FIBRINOGEN RECEPTOR; FLECAINIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N(G),N(G) DIMETHYLARGININE; PADGEM PROTEIN; SOTALOL; WARFARIN; ARGININE; BETA3 INTEGRIN; BIOLOGICAL MARKER; N,N-DIMETHYLARGININE;

ABLATION CATHETER; ADULT; ANTICOAGULANT THERAPY; ARTICLE; ATRIAL FIBRILLATION; BLOOD VESSEL FUNCTION; CATHETER ABLATION; ELECTROCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HOLTER MONITORING; HUMAN; HYPERTENSION; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT DISEASE; RISK ASSESSMENT; SENESCENCE; SINUS RHYTHM; THROMBOCYTE ACTIVATION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSTHORACIC ECHOCARDIOGRAPHY; VASCULAR ENDOTHELIUM; AGED; ANALOGS AND DERIVATIVES; BLOOD; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; PROSPECTIVE STUDY; STROKE;

AGED; ARGININE; ATRIAL FIBRILLATION; BIOLOGICAL MARKERS; CATHETER ABLATION; ELECTROCARDIOGRAPHY; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTEGRIN BETA3; MALE; MIDDLE AGED; P-SELECTIN; PLATELET ACTIVATION; PROSPECTIVE STUDIES; RECURRENCE; STROKE;

EID: 84923510766     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.07.030     Document Type: Article

References (31)

1. Wolf, P.A., Abbott, R.D., Kannel, W.B., Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 22 (1991), 983–988.
2. Akar, J.G., Jeske, W., Wilber, D.J., Acute onset human atrial fibrillation is associated with local cardiac platelet activation and endothelial dysfunction. J Am Coll Cardiol 51 (2008), 1790–1793.
3. Lim, H.S., Willoughby, S.R., Schultz, C., et al. Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm. J Am Coll Cardiol 61 (2013), 852–860.
4. Willoughby, S.R., Roberts-Thomson, R.L., Lim, H.S., Schultz, C., Prabhu, A., De Sciscio, P., Wong, C.X., Worthley, M.I., Sanders, P., Atrial platelet reactivity in patients with atrial fibrillation. Heart Rhythm 7 (2010), 1178–1183.
5. Mondillo, S., Sabatini, L., Agricola, E., Ammaturo, T., Guerrini, F., Barbati, R., Pastore, M., Fineschi, D., Nami, R., Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation. Int J Cardiol 75 (2000), 227–232.
6. Watson, T., Shantsila, E., Lip, G.Y.H., Mechanisms of thrombogenesis in atrial fibrillation: Virchow׳s triad revisited. The Lancet 373 (2009), 155–166.
7. Willoughby, S.R., Stewart, S., Holmes, A.S., Chirkov, Y.Y., Horowitz, J.D., Platelet nitric oxide responsiveness: a novel prognostic marker in acute coronary syndromes. Arterioscler Thromb Vasc Biol 25 (2005), 2661–2666.
8. Kamath, S., Chin, B.S., Blann, A.D., Lip, G.Y., A study of platelet activation in paroxysmal, persistent and permanent atrial fibrillation. Blood Coagul Fibrinolysis 13 (2002), 627–636.
9. Skalidis, E.I., Zacharis, E.A., Tsetis, D.K., Pagonidis, K., Chlouverakis, G., Yarmenitis, S., Hamilos, M., Manios, E.G., Vardas, P.E., Endothelial cell function during atrial fibrillation and after restoration of sinus rhythm. Am J Cardiol 99 (2007), 1258–1262.
10. Takahashi, N., Ishibashi, Y., Shimada, T., et al. Atrial fibrillation impairs endothelial function of forearm vessels in humans. J Card Fail 7 (2001), 45–54.
11. Calkins, H., Kuck, K.H., Cappato, R., et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Heart Rhythm 9 (2012), 632–696 e621.
12. Stiles, M.K., John, B., Wong, C.X., Kuklik, P., Brooks, A.G., Lau, D.H., Dimitri, H., Roberts-Thomson, K.C., Wilson, L., De Sciscio, P., Young, G.D., Sanders, P., Paroxysmal lone atrial fibrillation is associated with an abnormal atrial substrate: characterizing the “second factor”. J Am Coll Cardiol 53 (2009), 1182–1191.
13. Lim, H.S., Schultz, C., Dang, J., Alasady, M., Lau, D.H., Brooks, A.G., Wong, C.X., Roberts-Thomson, K.C., Young, G.D., Worthley, M.I., Sanders, P., Willoughby, S.R., Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation. Circ Arrhythm Electrophysiol 7 (2014), 83–89.
14. Sanders, P., Morton, J.B., Kistler, P.M., Vohra, J.K., Kalman, J.M., Sparks, P.B., Reversal of atrial mechanical dysfunction after cardioversion of atrial fibrillation: implications for the mechanisms of tachycardia-mediated atrial cardiomyopathy. Circulation 108 (2003), 1976–1984.
15. Sohara, H., Amitani, S., Kurose, M., Miyahara, K., Atrial fibrillation activates platelets and coagulation in a time-dependent manner: a study in patients with paroxysmal atrial fibrillation. J Am Coll Cardiol 29 (1997), 106–112.
16. Goette, A., Ittenson, A., Hoffmanns, P., Reek, S., Hartung, W., Klein, H., Ansorge, S., Geller, J.C., Increased expression of P-selectin in patients with chronic atrial fibrillation. Pacing Clin Electrophysiol 23 (2000), 1872–1875.
17. Freestone, B., Chong, A.Y., Nuttall, S., Blann, A.D., Lip, G.Y., Soluble E-selectin, von Willebrand factor, soluble thrombomodulin, and total body nitrate/nitrite product as indices of endothelial damage/dysfunction in paroxysmal, persistent, and permanent atrial fibrillation. Chest 132 (2007), 1253–1258.
18. Fu, R., Wu, S., Wu, P., Qiu, J., A Study of blood soluble P-selectin, fibrinogen, and von Willebrand factor levels in idiopathic and lone atrial fibrillation. Europace 13 (2011), 31–36.
19. Minamino, T., Kitakaze, M., Sanada, S., Asanuama, H., Kurotobi, T., Koretsune, Y., Fukunami, M., Kuzuya, T., Hoki, N., Hori, M., Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide. Circulation 98 (1998), 1721–1727.
20. Dole, V.S., Bergmeier, W., Mitchell, H.A., Eichenberger, S.C., Wagner, D.D., Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106 (2005), 2334–2339.
21. Pongratz, G., Brandt-Pohlmann, M., Henneke, K.H., Pohle, C., Zink, D., Gehling, G., Bachmann, K., Platelet activation in embolic and preembolic status of patients with nonrheumatic atrial fibrillation. Chest 111 (1997), 929–933.
22. Atalar, E., Haznedaroglu, I.C., Acil, T., Ozer, N., Kilic, H., Ovunc, K., Aksoyek, S., Nazli, N., Kes, S., Kabakci, G., Kirazli, S., Ozmen, F., Patients with paroxysmal atrial fibrillation but not paroxysmal supraventricular tachycardia display evidence of platelet activation during arrhythmia. Platelets 14 (2003), 407–411.
23. Goette, A., Hammwohner, M., Bukowska, A., Scalera, F., Martens-Lobenhoffer, J., Dobrev, D., Ravens, U., Weinert, S., Medunjanin, S., Lendeckel, U., Bode-Boger, S.M., The impact of rapid atrial pacing on ADMA and endothelial NOS. Int J Cardiol 154 (2012), 141–146.
24. Stuhlinger, M.C., Oka, R.K., Graf, E.E., Schmolzer, I., Upson, B.M., Kapoor, O., Szuba, A., Malinow, M.R., Wascher, T.C., Pachinger, O., Cooke, J.P., Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 108 (2003), 933–938.
25. Cai, H., Li, Z., Goette, A., Mera, F., Honeycutt, C., Feterik, K., Wilcox, J.N., Dudley, S.C. Jr., Harrison, D.G., Langberg, J.J., Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke. Circulation 106 (2002), 2854–2858.
26. Meinitzer, A., Seelhorst, U., Wellnitz, B., Halwachs-Baumann, G., Boehm, B.O., Winkelmann, B.R., Marz, W., Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study). Clin Chem 53 (2007), 273–283.
27. Guazzi, M., Belletti, S., Lenatti, L., Bianco, E., Guazzi, M.D., Effects of cardioversion of atrial fibrillation on endothelial function in hypertension or diabetes. Eur J Clin Invest 37 (2007), 26–34.
28. Shin, S.Y., Na, J.O., Lim, H.E., et al. Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation. J Cardiovasc Electrophysiol 22 (2011), 376–382.
29. Rotter, M., Jais, P., Vergnes, M.C., Nurden, P., Takahashi, Y., Sanders, P., Rostock, T., Hocini, M., Sacher, F., Haissaguerre, M., Decline in C-reactive protein after successful ablation of long-lasting persistent atrial fibrillation. J Am Coll Cardiol 47 (2006), 1231–1233.
30. Marcus, G.M., Smith, L.M., Glidden, D.V., Wilson, E., McCabe, J.M., Whiteman, D., Tseng, Z.H., Badhwar, N., Lee, B.K., Lee, R.J., Scheinman, M.M., Olgin, J.E., Markers of inflammation before and after curative ablation of atrial flutter. Heart Rhythm 5 (2008), 215–221.
31. Hansen, J.B., Naalsund, T., Sandset, P.M., Svensson, B., Rebound activation of coagulation after treatment with unfractionated heparin and not with low molecular weight heparin is associated with partial depletion of tissue factor pathway inhibitor and antithrombin. Thromb Res 100 (2000), 413–417.