Cortisol, platelet serotonin content, and platelet activity in patients with major depression and type 2 diabetes: An exploratory investigation

Psychosomatic Medicine

Volumn 77, Issue 2, 2015, Pages 145-155

  Zahn, Daniela ^a   Petrak, Frank ^b   Franke, Leonora ^c   Hägele, Anna Karolina ^b   Juckel, Georg ^b   Lederbogen, Florian ^d   Neubauer, Horst ^e   Norra, Christine ^b   Uhl, Idun ^b   Herpertz, Stephan ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^e ST JOSEF HOSPITAL   (Germany)

Author keywords

CD40; cortisol; major depression; platelet activity; platelet serotonin content; Type 2 diabetes

Indexed keywords

BETA THROMBOGLOBULIN; C REACTIVE PROTEIN; CD40 ANTIGEN; CD40 LIGAND; CELL MARKER; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PADGEM PROTEIN; SEROTONIN; THROMBOCYTE FACTOR 4; TRIACYLGLYCEROL;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; PARAMETERS; PRIORITY JOURNAL; SALIVA LEVEL; THROMBOCYTE ACTIVATION; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COMPLICATION; FEMALE; MALE; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; SALIVA; THROMBOCYTE;

ANTIGENS, CD40; BETA-THROMBOGLOBULIN; BLOOD PLATELETS; CASE-CONTROL STUDIES; CD40 LIGAND; DEPRESSIVE DISORDER, MAJOR; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; P-SELECTIN; PLATELET FACTOR 4; SALIVA; SEROTONIN;

EID: 84923413813     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0000000000000145     Document Type: Article

References (64)

1. World Health Organization. Depression: a global public health concern [article online]. 2012. Available at: http:// www. Who. Int/mental-health/management/depression/who- paper-depression-wfmh-2012. Pdf. Accessed July 22, 2013.
2. Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adultswith Type 2 diabetes: a systematic review and meta-analysis. Diabet Med 2006;23: 1165-73.
3. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 2001;24:1069-78.
4. Golden SH, LazoM, CarnethonM, BertoniAG, Schreiner PJ, Roux AVD, Lee HB, Lyketsos C. Examining a bidirectional association between depressive symptoms and diabetes. JAMA 2008;299:2751-9.
5. Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and Type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 2008;31:2383-90.
6. Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry 2007;22:613-26.
7. Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 2006;27:2763-74.
8. Egede LE, Nietert PJ, Zheng D. Depression and all-cause and coronary heart disease mortality among adults with and without diabetes. Diabetes Care 2005;28:1339-45.
9. Lin EH, Rutter CM, KatonW, Heckbert SR, Ciechanowski P, OliverMM, Ludman EJ, Young BA,Williams LH, McCulloch DK, Von Korff M. Depression and advanced complications of diabetes: a prospective cohort study. Diabetes Care 2010; 33:264-9.
10. de Jonge P, Rosmalen JG, Kema IP, Doornbos B, van Melle JP, Pouwer F, Kupper N. Psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients: a critical review of the literature. Neurosci Biobehav Rev 2010;35:84-90.
11. Goldston K, Baillie AJ. Depression and coronary heart disease: a review of the epidemiological evidence, explanatory mechanisms and management approaches. Clin Psychol Rev 2008;28:288-306.
12. Stetler C, Miller GE. Depression and hypothalamic-pituitaryadrenal activation: a quantitative summary of four decades of research. Psychosom Med 2011;73:114-26.
13. Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism. Curr Opin Pharmacol 2009;9: 787-93.
14. Roberge C, Carpentier AC, Langlois MF, Baillargeon JP, Ardilouze JL, Maheux P, Gallo-Payet N. Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity. Am J Physiol Endocrinol Metab 2007; 293:E1465-78.
15. Liu H, Bravata DM, Cabaccan J, Raff H, Ryzen E. Elevated late-night salivary cortisol levels in elderly male Type 2 diabetic veterans. Clin Endocrinol (Oxf) 2005;63:642-9.
16. Bruehl H, Rueger M, Dziobek I, Sweat V, Tirsi A, Javier E, Arentoft A, Wolf OT, Convit A. Hypothalamic-pituitaryadrenal axis dysregulation and memory impairments in Type 2 diabetes. J Clin Endocr Metab 2007;92:2439-45.
17. Chiodini I, Torlontano M, Scillitani A, ArosioM, Bacci S, Di Lembo S, Epaminonda P, Augello G, Enrini R,Ambrosi B, Adda G, Trischitta V. Association of subclinical hypercortisolism with Type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol 2005;153: 837-44.
18. Lederbogen F, Hummel J, Fademrecht C, Krumm B, Kuhner C, Deuschle M, Ladwig KH, Meisinger C, Wichmann HE, Lutz H, Breivogel B. Flattened circadian cortisol rhythm in Type 2 diabetes. Exp Clin Endocr Diab 2011;119:573-5.
19. Champaneri S, Xu X, Carnethon MR, Bertoni AG, Seeman T, Diez Roux A, Golden SH. Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis. Metabolism 2012; 61:986-95.
20. Bruehl H, Wolf OT, Convit A. A blunted cortisol awakening response and hippocampal atrophy in Type 2 diabetes mellitus. Psychoneuroendocrinology 2009;34:815.
21. Alvarez A, Faccioli J, Guinzbourg M, Castex MM, Bayon C, Masson W, Bluro I, Kozak A, Sorroche P, Capurro L, Grosembacher L, Proietti A, Finkelsztein C, Costa L, Day PF, Cagide A, Litwak LE, Golden SH. Endocrine and inflammatory profiles in Type 2 diabetic patients with and without major depressive disorder. BMC Res Notes 2013;6:61.
22. von Känel R, Mausbach BT, Kudielka BM, Orth-Gomer K. Relation of morning serum cortisol to prothrombotic activity in women with stable coronary artery disease. J Thromb Thrombolysis 2008;25:165-72.
23. Dekker MJ, Koper JW, van Aken MO, Pols HA, Hofman A, de Jong FH, Kirschbaum C, Witteman JC, Lamberts SW, Tiemeier H. Salivary cortisol is related to atherosclerosis of carotid arteries. J Clin Endocr Metab 2008;93:3741-7.
24. Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A. Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PLoS One 2012;7:e31356.
25. von Känel R. Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence? Acta Psychiatr Scand 2004;110: 163-77.
26. Nijm J, Jonasson L. Inflammation and cortisol response in coronary artery disease. Ann Med 2009;41:224-33.
27. Sanner JE, Frazier L. The role of serotonin in depression and clotting in the coronary artery disease population. J Cardiovasc Nurs 2011;26:423-9.
28. Bach-Mizrachi H, Underwood MD, Tin A, Ellis SP, Mann JJ, Arango V. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol Psychiatry 2008; 13:507-13.
29. Nemeroff CB, Musselman DL. Are platelets the link between depression and ischemic heart disease? Am Heart J 2000;140: 57-62.
30. Parakh K, Sakhuja A, Bhat U, Ziegelstein RC. Platelet function in patients with depression. South Med J 2008;101:612-7.
31. Ziegelstein RC, Parakh K, Sakhuja A, Bhat U. Platelet function in patients with major depression. Intern Med J 2009; 39:38-43.
32. Franke L, Schewe HJ, Muller B, Campman V, Kitzrow W, Uebelhack R, Berghofer A, Muller-Oerlinghausen B. Serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5HT content and 5HT uptake. Life Sci 2000;67:301-15.
33. Muck-Seler D, Pivac N, Jakovljevic M, Sagud M, Mihaljevic-Peles A. Platelet 5-HT concentration and comorbid depression in war veterans with and without posttraumatic stress disorder. J Affect Disord 2003;75: 171-9.
34. Roggenbach J,Muller-Oerlinghausen B, Franke L,Uebelhack R, Blank S, Ahrens B. Peripheral serotonergic markers in acutely suicidal patients. 1. Comparison of serotonergic platelet measures between suicidal individuals, nonsuicidal patients with major depression and healthy subjects. J Neural Transm 2007;114:479-87.
35. Pivac N, Muck-Seler D, SagudM, JakovljevicM,Mustapic M, Mihaljevic-Peles A. Long-term sertraline treatment and peripheral biochemical markers in female depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27:759-65.
36. Muck-Seler D, Pivac N,MustapicM, Crncevic Z, Jakovljevic M, Sagud M. Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women. Psychiatry Res 2004;127:217-26.
37. Maurer-Spurej E, Pittendreigh C, Solomons K. The influence of selective serotonin reuptake inhibitors on human platelet serotonin. Thromb Haemost 2004;91:119-28.
38. Ruljancic N, Mihanovic M, Cepelak I. Thrombocyte serotonin and serum cholesterol concentration in suicidal and nonsuicidal depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1261-7.
39. Schins A, Hamulyak K, Scharpe S, Lousberg R, Van Melle J, Crijns H, Honig A. Whole blood serotonin and platelet activation in depressed post-myocardial infarction patients. Life Sci 2004;76:637-50.
40. Wulsin LR, Musselman D, Otte C, Bruce E, Ali S, Whooley MA. Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosom Med 2009;71:260-5.
41. Sanner JE, Frazier L, Udtha M. The role of platelet serotonin and depression in the acute coronary syndrome population. Yale J Biol Med 2013;86:5-13.
42. Barradas MA, Gill DS, Fonseca VA, Mikhailidis DP, Dandona P. Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. Eur J Clin Invest 1988;18:399-404.
43. Malyszko J, Urano T, Knofler R, Taminato A, Yoshimi T, Takada Y, Takada A. Daily variations of platelet aggregation in relation to blood and plasma serotonin in diabetes. Thromb Res 1994;75:569-76.
44. Pietraszek MH, Takada Y, Takada A, Fujita M, Watanabe I, Taminato A, Yoshimi T. Blood serotonergic mechanisms in Type-2 (non-insulin-dependent) diabetes-mellitus. Thromb Res 1992;66:765-74.
45. Hara K, Hirowatari Y, Shimura Y, Takahashi H. Serotonin levels in platelet-poor plasma and whole blood in people with Type 2 diabetes with chronic kidney disease. Diabetes Res Clin Pract 2011;94:167-71.
46. Zahn D, Petrak F, Uhl I, Juckel G, Neubauer H, Hagele AK, Wiltfang J, Herpertz S. New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atherosclerotic markers in patients with depression. J Affect Disord 2013; 146:420-5.
47. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001; 16:606-13.
48. Wittchen HU, Zaudig M, Fydrich T. Skid. Strukturiertes Klinisches Interview für DSM-IV. Göttingen: Hogrefe; 1997.
49. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, Markowitz JC, Ninan PT, Kornstein S, Manber R, Thase ME, Kocsis JH, Keller MB. The 16-item Quick Inventory of Depressive Symptomatology (QIDS), Clinician Rating (QIDS-C), and Self-Report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry 2003;54:573-83.
50. Lederbogen F, Kuhner C, Kirschbaum C, Meisinger C, Lammich J, Holle R, Krumm B, von Lengerke T, Wichmann HE, Deuschle M, Ladwig KH. Salivary cortisol in a middleaged community sample: results from 990 men and women of the KORA-F3 Augsburg study. Eur J Endocrinol 2010; 163:443-51.
51. Franke L, Schmidtmann M, Riedl A, van der Voort I, Uebelhack R,Monnikes H. Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of gender. J Gastroenterol 2010;45:389-98.
52. Neubauer H, Setiadi P, Gunesdogan B, Pinto A, Borgel J, Mugge A. Influence of glycaemic control on platelet bound CD40-CD40L system, P-selectin and soluble CD40 ligand in Type 2 diabetes. Diabet Med 2010;27:384-90.
53. Schonbeck U, Varo N, Libby P, Buring J, Ridker PM. Soluble CD40L and cardiovascular risk in women. Circulation 2001; 104:2266-8.
54. Faul F, Erdfelder E, Lang AG, Buchner A. G power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39:175-91.
55. Stetler C, Miller GE. Blunted cortisol response to awakening in mild to moderate depression: regulatory influences of sleep patterns and social contacts. J Abnorm Psychol 2005;114: 697-705.
56. Huber TJ, Issa K, Schik G, Wolf OT. The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. Psychoneuroendocrinology 2006;31:900-4.
57. Bhagwagar Z, Hafizi S, Cowen PJ. Increased salivary cortisol after waking in depression. Psychopharmacology (Berl) 2005; 182:54-7.
58. Vreeburg SA, Hoogendijk WJ, van Pelt J, Derijk RH, Verhagen JC, van Dyck R, Smit JH, Zitman FG, Penninx BW. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study. Arch Gen Psychiatry 2009;66:617-26.
59. Jarcho MR, Slavich GM, Tylova-Stein H, Wolkowitz OM, Burke HM. Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder. Biol Psychol 2013;93:150-8.
60. Knight JM, Avery EF, Janssen I, Powell LH. Cortisol and depressive symptoms in a population-based cohort of midlife women. Psychosom Med 2010;72:855-61.
61. Gragnoli C. Depression and Type 2 diabetes: cortisol pathway implication and investigational needs. J Cell Physiol 2012; 227:2318-22.
62. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS, Stefanadis C. The CD40/CD40 ligand system: Linking inflammation with atherothrombosis. J Am Coll Cardiol 2009;54:669-77.
63. Blann AD, Nadar SK, Lip GY. The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J 2003;24: 2166-79.
64. Pamukcu B, Lip GY, Snezhitskiy V, Shantsila E. The CD40-CD40L system in cardiovascular disease. Ann Med 2011; 43:331-40.