Large-scale manufacturing of GMP-compliant anti-EGFR targeted nanocarriers: Production of doxorubicin-loaded anti-EGFR-immunoliposomes for a first-in-man clinical trial

International Journal of Pharmaceutics

Volumn 484, Issue 1-2, 2015, Pages 8-15

  Wicki, Andreas ^a   Ritschard, Reto ^a   Loesch, Uli ^a   Deuster, Stefanie ^a   Rochlitz, Christoph ^a   Mamot, Christoph ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

EGFR; GMP production; Immunoliposomes; Nanocarrier; Phase I clinical trial; Targeted therapies

Indexed keywords

CETUXIMAB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANOSINE PHOSPHATE; IMMUNOLIPOSOME; NANOCARRIER; PHOSPHOLIPID; DRUG CARRIER; MACROGOL DERIVATIVE; NANOPARTICLE;

ARTICLE; COLORIMETRY; DRUG DEGRADATION; DRUG TRANSPORT; PARTICLE SIZE; PH; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CLINICAL TRIAL (TOPIC); DRUG DELIVERY SYSTEM; HUMAN; MEDICINAL CHEMISTRY; PROCEDURES; PROTOCOL COMPLIANCE; STANDARDS; SYNTHESIS;

CHEMISTRY, PHARMACEUTICAL; CLINICAL TRIALS AS TOPIC; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GUIDELINE ADHERENCE; HUMANS; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84923382198     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.02.034     Document Type: Article

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