Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation

Blood

Volumn 125, Issue 8, 2015, Pages 1339-1348

  Dinarvand, Peyman ^a   Hassanian, Seyed Mahdi ^a   Weiler, Hartmut ^b   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CELL ADHESION MOLECULE; D DIMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL PROTEIN C RECEPTOR; GAMMA INTERFERON; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; METALLOPROTEINASE; METALLOPROTEINASE 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE ACTIVATED RECEPTOR 1; TISSUE ADHESIVE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; VASCULAR CELL ADHESION MOLECULE 1; AUTACOID; CYTOKINE; PROTEIN C;

ADHESION BARRIER FILM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CELL COUNT; CELL SURFACE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; HUMAN; INFLAMMATION; MALE; MOUSE; NONHUMAN; PERITONEAL FLUID LEVEL; PERITONEUM ADHESION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SCORING SYSTEM; SIGNAL TRANSDUCTION; THERAPY EFFECT; TISSUE ADHESION; ANIMAL; C57BL MOUSE; DRUG SCREENING; GENETICS; INFUSION; KNOCKOUT MOUSE; METABOLISM; PERITONEAL DISEASES; PERITONITIS; POSTOPERATIVE COMPLICATIONS; TISSUE ADHESIONS;

ANIMALS; CYTOKINES; DRUG EVALUATION, PRECLINICAL; INFLAMMATION; INFLAMMATION MEDIATORS; INFUSIONS, PARENTERAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONEAL DISEASES; PERITONITIS; POSTOPERATIVE COMPLICATIONS; PROTEIN C; TISSUE ADHESIONS;

EID: 84923378695     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-10-609339     Document Type: Article

References (38)

1. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001;18(4):260-273.
2. Menzies D, Ellis H. Intestinal obstruction from adhesions-how big is the problem? Ann R Coll Surg Engl. 1990;72(1):60-63.
3. Menzies D. Peritoneal adhesions. Incidence, cause, and prevention. Surg Annu. 1992;24(Pt 1): 27-45.
4. Sulaiman H, Gabella G, Davis C, et al. Growth of nerve fibres into murine peritoneal adhesions. J Pathol. 2000;192(3):396-403.
5. Kavic SM, Kavic SM. Adhesions and adhesiolysis: the role of laparoscopy. JSLS. 2002;6(2):99-109.
6. Leach RE, Burns JW, Dawe EJ, SmithBarbour MD, Diamond MP. Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/ carboxymethylcellulose gel. Fertil Steril. 1998;69(3):415-418.
7. Hemadeh O, Chilukuri S, Bonet V, Hussein S, Chaudry IH. Prevention of peritoneal adhesions by administration of sodium carboxymethyl cellulose and oral vitamin E. Surgery. 1993; 114(5):907-910.
8. Hellebrekers BW, Trimbos-Kemper GC, van Blitterswijk CA, Bakkum EA, Trimbos JB. Effects of five different barrier materials on postsurgical adhesion formation in the rat. Hum Reprod. 2000; 15(6):1358-1363.
9. Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183(4):297-306.
10. Dinarvand P, Hashemi SM, Seyedjafari E, et al. Function of poly (lactic-co-glycolic acid) nanofiber in reduction of adhesion bands. J Surg Res. 2012; 172(1):e1-e9.
11. Practice Committee of American Society for Reproductive Medicine in collaboration with Society of Reproductive Surgeons. Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery: a committee opinion. Fertil Steril. 2013;99(6):1550-1555.
12. Saed GM, Zhang W, Diamond MP. Molecular characterization of fibroblasts isolated from human peritoneum and adhesions. Fertil Steril. 2001;75(4):763-768.
13. Saed GM, Diamond MP. Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. Fertil Steril. 2003;79(1): 164-168.
14. Rout UK, Saed GM, Diamond MP. Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblasts. Fertil Steril. 2002;78(1): 154-161.
15. Chegini N. TGF-b system: the principal profibrotic mediator of peritoneal adhesion formation. Semin Reprod Med. 2008;26(4):298-312.
16. White JC, Jiang ZL, Diamond MP, Saed GM. Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts. Fertil Steril. 2011; 96(3):758-763.e3.
17. Bernard GR, Vincent JL, Laterre PF, et al; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344(10):699-709.
18. Mitka M. Drug for severe sepsis is withdrawn from market, fails to reduce mortality. JAMA. 2011; 306(22):2439-2440.
19. Taylor FB Jr, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest. 1987; 79(3):918-925.
20. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007; 109(8):3161-3172.
21. Comp PC, Esmon CT. Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest. 1981;68(5):1221-1228.
22. Kerschen EJ, Fernandez JA, Cooley BC, et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007;204(10):2439-2448.
23. Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. J Thromb Haemost. 2009;7(Suppl 1):140-145.
24. Costa R, Morrison A, Wang J, Manithody C, Li J, Rezaie AR. Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart. J Thromb Haemost. 2012;10(9): 1736-1744.
25. Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296(5574): 1880-1882.
26. Rezaie AR. Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem. 2010;17(19):2059-2069.
27. Castellino FJ, Liang Z, Volkir SP, et al. Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. Thromb Haemost. 2002;88(3):462-472.
28. Darrow AL, Fung-Leung WP, Ye RD, et al. Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost. 1996;76(6): 860-866.
29. Connolly AJ, Ishihara H, Kahn ML, Farese RV Jr, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996;381(6582):516-519.
30. Dinarvand P, Farhadian S, Seyedjafari E, et al. Novel approach to reduce postsurgical adhesions to a minimum: administration of losartan plus atorvastatin intraperitoneally. J Surg Res. 2013; 181(1):91-98.
31. Nair SK, Bhat IK, Aurora AL. Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions. Arch Surg. 1974; 108(6):849-853.
32. Hooker GD, Taylor BM, Driman DK. Prevention of adhesion formation with use of sodium hyaluronate-based bioresorbable membrane in a rat model of ventral hernia repair with polypropylene mesh-a randomized, controlled study. Surgery. 1999;125(2):211-216.
33. Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239.
34. Topal E, Ozturk E, Sen G, Yerci O, Yilmazlar T. A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions. Acta Chir Belg. 2010;110(1):71-75.
35. Rezaie AR. Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. J Biol Chem. 2001;276(19): 15567-15570.
36. Atta HM, Al-Hendy A, El-Rehany MA, et al. Adenovirus-mediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats. Surgery. 2009;146(1):12-17.
37. Burnier L, Mosnier LO. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of proteaseactivated receptor 3. Blood. 2013;122(5):807-816.
38. Schuepbach RA, Madon J, Ender M, Galli P, Riewald M. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost. 2012;10(8):1675-1684.