The common food additive carrageenan is not a ligand for Toll-Like- Receptor 4 (TLR4) in an HEK293-TLR4 reporter cell-line model

Food and Chemical Toxicology

Volumn 78, Issue , 2015, Pages 153-158

  McKim, James M ^a   Wilga, Paul C ^b   Pregenzer, Jeffrey F ^b   Blakemore, William R ^c  

^a IONTOX LLC   (United States)

^b CYPROTEX DISCOVERY LTD   (United Kingdom)

^c Celtic Colloids Inc   (United States)

Author keywords

Carrageenan; In vitro; Inflammation; Protein binding; TLR4

Indexed keywords

ALKALINE PHOSPHATASE; CARRAGEENAN; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; PROTEIN MD 2; SECRETABLE ALKALINE PHOSPHATASE; TOLL LIKE RECEPTOR 4; TOLONIUM CHLORIDE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; FOOD ADDITIVE; LIGAND; LIPOPOLYSACCHARIDE; TLR4 PROTEIN, HUMAN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; HEK293 CELL LINE; HEK293 TOLL LIKE RECEPTOR 4 REPORTER CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN BINDING; SIGNAL TRANSDUCTION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT;

ANIMALIA;

ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; CARRAGEENAN; CELL SURVIVAL; FOOD ADDITIVES; HEK293 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LIGANDS; LIPOPOLYSACCHARIDES; NF-KAPPA B; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84923378134     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.01.003     Document Type: Article

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