Expression patterns of B cells in acute kidney transplant rejection

Experimental and Clinical Transplantation

Volumn 12, Issue 5, 2014, Pages 405-414

  Carpio, Virna Nowotny ^a   De Lourdes Noronha, Irene ^b   Martins, Hugo Ludovico ^b   Jobim, Luiz Fernando ^a   Gil, Beatriz Chamun ^a   Külzer, Adriane Silva ^a   da Silva Loreto, Melina ^a   Santos Gonçalves, Luiz Felipe ^a   Manfro, Roberto Ceratti ^a   Veronese, Francisco Veríssimo ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

C4d; CD138; CD20; Donor specific antibodies; Lymphocytes; Plasma cells

Indexed keywords

CD20 ANTIGEN; COMPLEMENT COMPONENT C4D; HLA ANTIBODY; HLA ANTIGEN; PARAFFIN; PEROXIDASE; SYNDECAN 1; AUTOANTIBODY; BIOLOGICAL MARKER; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT; SDC1 PROTEIN, HUMAN;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BIOPSY TECHNIQUE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; IMMUNOREACTIVITY; KIDNEY ALLOGRAFT REJECTION; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; PLASMA CELL; RISK FACTOR; T LYMPHOCYTE; TREATMENT OUTCOME; ACUTE DISEASE; ADVERSE EFFECTS; BIOPSY; BLOOD; CHI SQUARE DISTRIBUTION; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KAPLAN MEIER METHOD; KIDNEY; KIDNEY TRANSPLANTATION; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PREDICTIVE VALUE; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; TIME; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIGENS, CD20; AUTOANTIBODIES; B-LYMPHOCYTES; BIOLOGICAL MARKERS; BIOPSY; CHI-SQUARE DISTRIBUTION; COMPLEMENT C4B; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HLA ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PEPTIDE FRAGMENTS; PLASMA CELLS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SYNDECAN-1; T-LYMPHOCYTES; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84923358696     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: 10.6002/ect.2014.0049     Document Type: Article

References (31)

1. Regele H, Exner M, Watschinger B, et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant. 2001;16(10):2058-2066.
2. Gaston RS, Cecka JM, Kasiske BL, et al. Evidence for antibodymediated injury as a major determinant of late kidney allograft failure. Transplantation. 2010;90(1):68-74.
3. Crespo M, Pascual M, Tolkoff-Rubin N, et al. Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics. Transplantation. 2001;71(5):652-658.
4. Lederer SR, Kluth-Pepper B, Schneeberger H, Albert E, Land W, Feucht HE. Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts. Kidney Int. 2001;59(1):334-341.
5. Worthington JE, McEwen A, McWilliam LJ, Picton ML, Martin S. Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome. Transplantation. 2007;83(4):398-403.
6. Haririan A, Kiangkitiwan B, Kukuruga D, et al. The impact of C4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy. Am J Transplant. 2009;9(12):2758-2767.
7. Herzenberg AM, Gill JS, Djurdjev O, Magil AB. C4d deposition in acute rejection: an independent long-term prognostic factor. J Am Soc Nephrol. 2002;13(1):234-241.
8. Kayler LK, Lakkis FG, Morgan C, et al. Acute cellular rejection with CD20-positive lymphoid clusters in kidney transplant patients following lymphocyte depletion. Am J Transplant. 2007;7(4):949-954.
9. Scheepstra C, Bemelman FJ, van der Loos C, et al. B cells in cluster or in a scattered pattern do not correlate with clinical outcome of renal allograft rejection. Transplantation. 2008;86(6):772-778.
10. Hippen BE, DeMattos A, Cook WJ, Kew CE, Gaston RS. Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant. 2005;5(9):2248-2252.
11. Muorah MR, Brogan PA, Sebire NJ, Trompeter RS, Marks SD. Dense B cell infiltrates in paediatric renal transplant biopsies are predictive of allograft loss. Pediatr Transplant. 2009;13(2):217-222.
12. Tsai EW, Wallace WD, Gjertson DW, Reed EF, Ettenger RB. Significance of intragraft CD138+ lymphocytes and p-S6RP in pediatric kidney transplant biopsies. Transplantation. 2010;90 (8):875-881.
13. Bagnasco SM, Tsai W, Rahman MH, et al. CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival. Am J Transplant. 2007;7(8): 1968-1973.
14. Zarkhin V, Chalasani G, Sarwal MM. The yin and yang of B cells in graft rejection and tolerance. Transplant Rev (Orlando). 2010; 24(2):67-78.
15. Stegall MD, Raghavaiah S, Gloor JM. The (re)emergence of B cells in organ transplantation. Curr Opin Organ Transplant. 2010; 15(4): 451-455.
16. Zarkhin V, Kambham N, Li L, et al. Characterization of intra-graft B cells during renal allograft rejection. Kidney Int. 2008;74(5):664-673.
17. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant. 2008;8(4):753-760.
18. Gundersen HJ, Bendtsen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96(5):379-394.
19. Martins HL, Silva C, Martini D, Noronha IL. Detection of B lymphocytes (CD20+) in renal allograft biopsy specimens. Transplant Proc. 2007;39(2):432-434.
20. Colvin RB. Antibody- mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol. 2007;18(4):1046-1056.
21. Regele H, Böhmig GA, Habicht A, et al. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol. 2002;13(9):2371-2380.
22. Sarwal M, Chua MS, Kambham N, et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med. 2003;349(2):125-138.
23. Martin L, Charon-Barra C, Bocrie O, et al. Detection of plasma cells, C4d deposits and donor-specific antibodies on sequential graft biopsies of renal transplant recipients with chronic dysfunction. Transplant Immunol. 2010;22(3-4):110-114.
24. Zarkhin V, Li L, Sarwal M. “To B or Not to B?” B-cells and graft rejection. Transplantation. 2008;85(12):1705-1714.
25. Tsai EW, Rianthavorn P, Gjertson DW, Wallace WD, Reed EF, Ettenger RB. CD20+ lymphocytes in renal allografts are associated with poor graft survival in pediatric patients. Transplantation. 2006;82(12):1769-1773.
26. Hwang HS, Song JH, Hyoung BJ, et al. Clinical impacts of CD38+ B cells on acute cellular rejection with CD20+ B cells in renal allograft. Transplantation. 2010;89(12):1489-1495.
27. Desvaux D, Le Gouvello S, Pastural M, et al. Acute renal allograft rejections with major interstitial oedema and plasma cell-rich infiltrates: high gamma-interferon expression and poor clinical outcome. Nephrol Dial Transplant. 2004;19(4):933-939.
28. Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant. 2004;4(3):378-383.
29. Jiqiu W, Jinsong C, Dongrui C, Mingchao Z, Shuming J, Zhi-Hong L. CD20+ B-cell infiltration is related to the time after transplant and poor prognosis of acute cellular rejection in renal transplant. Exp Clin Transplant. 2013;11(5):412-417.
30. Chang A, Moore JM, Cowan ML, et al. Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection. Transpl Int. 2012;25(10):1050-1058.
31. Sellarés J, de Freitas DG, Mengel M, et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant. 2012;12(2):388-399.