Prevalence of non-responsiveness to an indigenous recombinant hepatitis B vaccine: A study among South Indian health care workers in a tertiary hospital

Indian Journal of Medical Microbiology

Volumn 33, Issue , 2015, Pages S32-S36

  Thomas, R J ^a   Fletcher, G J ^a   Kirupakaran, H ^a   Chacko, M P ^a   Thenmozhi, S ^a   Eapen, C E ^a   Chandy, G ^a   Abraham, P ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Health care workers; Hepatitis B vaccine; Non responders

Indexed keywords

HEPATITIS B SURFACE ANTIBODY; RECOMBINANT HEPATITIS B VACCINE; HEPATITIS B ANTIBODY; HEPATITIS B VACCINE; RECOMBINANT VACCINE;

ADOLESCENT; ADULT; ANTIBODY TITER; ANTIVIRAL RESISTANCE; ARTICLE; BODY MASS; FEMALE; HEALTH CARE PERSONNEL; HEALTHCARE ASSOCIATED INFECTION; HEPATITIS B; HLA SYSTEM; HLA TYPING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; IMMUNE RESPONSE; INDIAN; MALE; MICROPARTICLE ENZYME IMMUNOASSAY; POLYMERASE CHAIN REACTION; SEROCONVERSION; SEX DIFFERENCE; TERTIARY CARE CENTER; VACCINATION; HEPATITIS B VIRUS; IMMUNOLOGY; INDIA; LONGITUDINAL STUDY; PREVALENCE;

FEMALE; HEALTH PERSONNEL; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HUMANS; INDIA; LONGITUDINAL STUDIES; MALE; PREVALENCE; TERTIARY CARE CENTERS; VACCINATION; VACCINES, SYNTHETIC;

EID: 84923356683     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.150877     Document Type: Article

References (20)

1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
2. Chaudhari CN, Bhagat MR, Ashturkar A, Misra RN. Hepatitis B Immunisation in Health Care Workers. Med J Armed Forces India 2009;65:13-7.
3. Havlichek D Jr, Rosenman K, Simms M, Guss P. Age-related hepatitis B seroconversion rates in health care workers. Am J Infect Control 1997;25:418-20.
4. Louther J, Feldman J, Rivera P, Villa N, DeHovitz J, Sepkowitz KA. Hepatitis B vaccination program at a New York City hospital: Seroprevalence, seroconversion, and declination. Am J Infect Control 1998;26:423-7.
5. Singh R, Kaul R, Kaul A, Khan K. A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol 2007;13:1770-87.
6. Zuckerman JN, Sabin C, Craig FM, Williams A, Zuckerman AJ. Immune response to a new hepatitis B vaccine in healthcare workers who had not responded to standard vaccine: Randomised double blind dose-response study. BMJ 1997;314:329-33.
7. Averhoff F, Mahoney F, Coleman P, Schatz G, Hurwitz E, Margolis H. Immunogenicity of hepatitis B Vaccines. Implications for persons at occupational risk of hepatitis B virus infection. Am J Prev Med 1998;15:1-8.
8. Zeeshan M, Jabeen K, Ali AN, Ali AW, Farooqui SZ, Mehraj V, et al. Evaluation of immune response to Hepatitis B vaccine in health care workers at a tertiary care hospital in Pakistan: An observational prospective study. BMC Infect Dis 2007;7:120.
9. Das K, Gupta RK, Kumar V, Singh S, Kar P. Association of HLA phenotype with primary non-response to recombinant hepatitis B vaccine: A study from north India. Trop Gastroenterol 2004;25:113-5.
10. Snehalatha C, Viswanathan V, Ramachandran A. Cutoff values for normal anthropometric variables in Asian Indian adults. Diabetes Care 2003;26:1380-4.
11. Velu V, Nandakumar S, Shanmugam S, Jadhav SS, Kulkarni PS, Thyagarajan SP. Comparison of three different recombinant hepatitis B vaccines: GeneVac-B, Engerix B and Shanvac B in high risk infants born to HBsAg positive mothers in India. World J Gastroenterol 2007;13:3084-9.
12. Vijayakumar V, Hari R, Parthiban R, Mehta J, Thyagarajan SP. Evaluation of immunogenicity and safety of Genevac B: A new recombinant hepatitis B vaccine in comparison with Engerix B and Shanvac B in healthy adults. Indian J Med Microbiol 2004;22:34-8.
13. Thakur V, Pati NT, Gupta RC, Sarin SK. Efficacy of Shanvac-B recombinant DNA hepatitis B vaccine in health care workers of Northern India. Hepatobiliary Pancreat Dis Int 2010;9:393-7.
14. Sangfelt P, Uhnoo I, Reichard O, Weiland O. A low-dose intradermal hepatitis B vaccine program in health-care workers and students is highly effective and cost saving: A retrospective follow-up survey in the clinical setting. Scand J Gastroenterol 2008;43:465-72.
15. Sjogren MH. Prevention of hepatitis B in nonresponders to initial hepatitis B virus vaccination. Am J Med 2005;118 Suppl 10A: 34-9S.
16. Yu AS, Cheung RC, Keeffe EB. Hepatitis B vaccines. Infect Dis Clin North Am 2006;20:27-45.
17. Ingardia CJ, Kelley L, Steinfeld JD, Wax JR. Hepatitis B vaccination in pregnancy: Factors influencing efficacy. Obstet Gynecol 1999;93:983-6.
18. Pitchappan RM, Kavitha VJ, Jayalakshmi M. HLA Genomic Diversity of India and its Implications in HIV pandemic. Int J Hum Genet 2008;8:143-53.
19. Vivekanandan P, Abraham P, Sridharan G, Chandy G, Daniel D, Raghuraman S, et al. Distribution of hepatitis B virus genotypes in blood donors and chronically infected patients in a tertiary care hospital in southern India. Clin Infect Dis 2004;38:e81-6.
20. Sukriti, Pati NT, Sethi A, Agrawal K, Agrawal K, Kumar GT, et al. Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India. J Gastroenterol Hepatol 2008;23:1710-5.