The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: Results from a multicenter observational study

Radiation Oncology Journal

Volumn 32, Issue 3, 2014, Pages 156-162

  Kang, Hyun Cheol ^a,b   Ahn, Seung Do ^c   Choi, Doo Ho ^d   Kang, Min Kyu ^e   Chung, Woong Ki ^f   Wu, Hong Gyun ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Asan Medical Center   (South Korea)

^d Samsung Medical Center   (South Korea)

^e Yeungnam University College of Medicine   (South Korea)

^f Chonnam National University Research Institute of Medical Sciences   (South Korea)

Author keywords

Cancer; Dermatitis; Epidermal growth factor; Radiation induced dermatitis; Radiotherapy

Indexed keywords

GAMMA UROGASTRONE;

ADULT; AGED; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DERMATITIS; DESQUAMATION; DRUG SAFETY; DRY SKIN; EDEMA; ERYTHEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEOPLASM; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; PRURITUS; RADIATION DOSE; RATING SCALE; SKIN NECROSIS; SKIN TOXICITY;

EID: 84923331947     PISSN: 22341900     EISSN: 22343156     Source Type: Journal    
DOI: 10.3857/roj.2014.32.3.156     Document Type: Article

References (26)

1. Harper JL, Franklin LE, Jenrette JM, Aguero EG. Skin toxicity during breast irradiation: pathophysiology and management. South Med J 2004;97:989-93.
2. Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol 2006;54:28-46.
3. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008;26:2085-92.
4. Fisher J, Scott C, Stevens R, et al. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 2000;48:1307-10.
5. Lee SY, Kwon HC, Kim JS, Lee HK. An analysis of the incidence and related factors for radiation dermatitis in breast cancer patients who received radiation therapy. J Korean Soc Ther Radiol Oncol 2010;28:16-22.
6. Bolderston A, Lloyd NS, Wong RK, Holden L, Robb-Blenderman L; Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care. The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer 2006;14:802-17.
7. Lee SW, Jung KI, Kim YW, Jung HD, Kim HS, Hong JP. Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats. Int J Radiat Oncol Biol Phys 2007;67:1172-8.
8. Ryu SH, Kim YH, Lee SW, Hong JP. The preventive effect of recombinant human growth factor (rhEGF) on the recurrence of radiodermatitis. J Radiat Res 2010;51:511-7.
9. Wu HG, Song SY, Kim YS, et al. Therapeutic effect of recom-binant human epidermal growth factor (RhEGF) on mucositis in patients undergoing radiotherapy, with or without chemotherapy, for head and neck cancer: a double-blind placebo-controlled prospective phase 2 multi-institutional clinical trial. Cancer 2009;115:3699-708.
10. Denham JW, Hauer-Jensen M. The radiotherapeutic injury: a complex 'wound'. Radiother Oncol 2002;63:129-45.
11. Olascoaga A, Vilar-Compte D, Poitevin-Chacon A, Contreras-Ruiz J. Wound healing in radiated skin: pathophysiology and treatment options. Int Wound J 2008;5:246-57.
12. Haubner F, Ohmann E, Pohl F, Strutz J, Gassner HG. Wound healing after radiation therapy: review of the literature. Radiat Oncol 2012;7:162.
13. Hong JP, Jung HD, Kim YW. Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers. Ann Plast Surg 2006;56:394-400.
14. Chan RJ, Larsen E, Chan P. Re-examining the evidence in radiation dermatitis management literature: an overview and a critical appraisal of systematic reviews. Int J Radiat Oncol Biol Phys 2012;84:e357-62.
15. Zhang Y, Zhang S, Shao X. Topical agent therapy for prevention and treatment of radiodermatitis: a meta-analysis. Support Care Cancer 2013;21:1025-31.
16. Schmuth M, Wimmer MA, Hofer S, et al. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br J Dermatol 2002;146:983-91.
17. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004;22:1447-53.
18. Niazi TM, Vuong T, Azoulay L, et al. Silver clear nylon dressing is effective in preventing radiation-induced dermatitis in patients with lower gastrointestinal cancer: results from a phase III study. Int J Radiat Oncol Biol Phys 2012;84:e305-10.
19. Kong M, Hong SE. Topical use of recombinant human epidermal growth factor (EGF)-based cream to prevent radiation dermatitis in breast cancer patients: a single-blind randomized preliminary study. Asian Pac J Cancer Prev 2013;14:4859-64.
20. Elliott EA, Wright JR, Swann RS, et al. Phase III Trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13. J Clin Oncol 2006;24:2092-7.
21. Choi J, Moon SY, Hong JP, Song JY, Oh KT, Lee SW. Epidermal growth factor induces cell death in the absence of overexpressed epidermal growth factor receptor and ErbB2 in various human cancer cell lines. Cancer Invest 2010;28:505-14.
22. Geissler C, Hambek M, Eckardt A, et al. The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model. Oncol Rep 2012;28:785-90.
23. Ozawa S, Ueda M, Ando N, Abe O, Hirai M, Shimizu N. Stimulation by EGF of the growth of EGF receptor-hyperpro ducing tumor cells in athymic mice. Int J Cancer 1987;40:706-10.
24. Ginsburg E, Vonderhaar BK. Epidermal growth factor stimulates the growth of A431 tumors in athymic mice. Cancer Lett 1985;28:143-50.
25. Berlanga-Acosta J, Gavilondo-Cowley J, Lopez-Saura P, et al. Epidermal growth factor in clinical practice: a review of its biological actions, clinical indications and safety implications. Int Wound J 2009;6:331-46.
26. Schmuth M, Sztankay A, Weinlich G, et al. Permeability barrier function of skin exposed to ionizing radiation. Arch Dermatol 2001;137:1019-23.