Primary human cytomegalovirus infections: Kinetics of ELISA-IgG and neutralizing antibody in pauci/asymptomatic pregnant women vs symptomatic non-pregnant subjects

Journal of Clinical Virology

Volumn 64, Issue , 2015, Pages 45-51

  Fornara, Chiara ^a   Furione, Milena ^a   Lilleri, Daniele ^a   Cane, Ilaria ^a   Revello, M Grazia ^b   Zavattoni, Maurizio ^a   Gerna, Giuseppe ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

ELISA IgG antibodies; HCMV glycoprotein complexes; HCMV load; Neutralizing antibodies; Symptomatic asymptomatic HCMV infections

Indexed keywords

IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; GLYCOPROTEIN; VIRUS ANTIBODY;

ADULT; ANTIBODY RESPONSE; ARTICLE; ASYMPTOMATIC INFECTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DEMOGRAPHY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CYTOMEGALOVIRUS; KINETICS; PREGNANT WOMAN; PRIMARY INFECTION; PRIORITY JOURNAL; VIRUS LOAD; AGED; BLOOD; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; IMMUNOLOGY; MALE; MIDDLE AGED; PREGNANCY; PREGNANCY COMPLICATION; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY; YOUNG ADULT;

ADULT; AGED; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ASYMPTOMATIC INFECTIONS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN G; KINETICS; MALE; MIDDLE AGED; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; REAL-TIME POLYMERASE CHAIN REACTION; VIRAL LOAD; YOUNG ADULT;

EID: 84923329965     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2015.01.004     Document Type: Article

References (23)

1. Fowler K.B., Stagno S., Pass R.F., Britt W.J., Boll T.J., Alford C.A. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N. Engl. J. Med. 1992, 326:663-667.
2. Revello M.G., Lazzarotto T., Guerra B., Spinillo A., Ferrazzi E., Kustermann A., et al. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N. Engl. J. Med. 2014, 370:1314-1324.
3. Revello M.G., Genini E., Gorini G., Klersy C., Piralla A., Gerna G. Comparative evaluation of eight commercial human cytomegalovirus IgG avidity assays. J. Clin. Virol. 2010, 48:255-259.
4. Revello M.G., Gerna G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin. Microbiol. Rev. 2002, 15:680-715.
5. Revello M.G., Fabbri E., Furione M., Zavattoni M., Lilleri D., Tassis B., et al. Role of prenatal diagnosis and counseling in the management of 735 pregnancies complicated by primary human cytomegalovirus infection: a 20-year experience. J. Clin. Virol. 2011, 50:303-307.
6. Furione M., Rognoni V., Cabano E., Baldanti F. Kinetics of human cytomegalovirus (HCMV) DNAemia in transplanted patients expressed in International Units as determined with the Abbott RealTime CMV assay and an in-house assay. J. Clin. Virol. 2012, 55:317-322.
7. Lilleri D., Kabanova A., Revello M.G., Percivalle E., Sarasini A., Genini E., et al. Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection. PLoS ONE 2013, 8:e59863.
8. Gerna G., Sarasini A., Patrone M., Percivalle E., Fiorina L., Campanini G., et al. Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection. J. Gen. Virol. 2008, 89:853-865.
9. Gerna G., Baldanti F., Percivalle E., Zavattoni M., Campanini G., Revello M.G. Early identification of human cytomegalovirus strains by the shell vial assay is prevented by a novel amino acid substitution in UL123 IE1 gene product. J. Clin. Microbiol. 2003, 41:4494-4495.
10. Klemola E., Von Essen R., Henle G., Henle W. Infectious-mononucleosis-like disease with negative heterophil agglutination test: clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies. J. Infect. Dis. 1970, 121:608-614.
11. Stagno S., Pass R.F., Cloud G., Britt W.J., Henderson R.E., Walton P.D., et al. Primary cytomegalovirus infection in pregnancy incidence, transmission to fetus, and clinical outcome. JAMA 1986, 256:1904-1908.
12. Griffiths P.D., Baboonian C. A prospective study of primary cytomegalovirus infection during pregnancy: final report. Br. J. Obstet. Gynaecol. 1984, 91:307-315.
13. Peckham C.S., Chin K.S., Coleman J.C., Henderson K., Hurley R., Preece P.M. Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet 1983, 1:1352-1355.
14. Jordan M.C., Rousseau W., Stewart J.A., Noble G.R., Chin T.D. Spontaneous cytomegalovirus mononucleosis: clinical and laboratory observations in nine cases. Ann. Intern. Med. 1973, 79:153-160.
15. Pannuti C.S., Vilas Boas L.S., Angelo M.J., Amato Neto V., Levi G.C., de Mendonca J.S., et al. Cytomegalovirus mononucleosis in children and adults: differences in clinical presentation. Scand. J. Infect. Dis. 1985, 17:153-156.
16. Revello M.G., Gerna G. Diagnosis and implications of human cytomegalovirus infection in pregnancy. Fetal. Matern. Med. Rev. 1999, 11:117-134.
17. Nigro G., Adler S.P., La Torre R., Best A.M. Passive immunization during pregnancy for congenital cytomegalovirus infection. N. Engl. J. Med. 2005, 353:1350-1362.
18. Macagno A., Bernasconi N.L., Vanzetta F., Dander E., Sarasini A., Revello M.G., et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex. J. Virol. 2010, 84:1005-1013.
19. Natali A., Valcavi P., Medici M.C., Dieci E., Montali S., Chezzi C. Cytomegalovirus infection in an Italian population: antibody prevalence, virus excretion and maternal transmission. Microbiologica 1997, 20:123-133.
20. Maingi Z., Nyamache A.K. Seroprevalence of cytomegalovirus (CMV) among pregnant women in Thika, Kenya. BMC Res. Notes 2014, 7:794.
21. Grossi P., Minoli L., Percivalle E., Irish W., Viganò M., Gerna G. Clinical and virological monitoring of human cytomegalovirus infection in 294 heart transplant recipients. Transplantation 1995, 59:847-851.
22. Cope A.V., Sabin C., Burroughs A., Rolles K., Griffiths P.D., Emery V.C. Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation. J. Infect. Dis. 1997, 176:1484-1490.
23. Lilleri D., Zelini P., Fornara C., Comolli G., Revello M.G., Gerna G. Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host. Clin. Immunol. 2009, 131:395-403.