Immunization in cancer patients: Where we stand

Pharmacological Research

Volumn 92, Issue , 2015, Pages 23-30

  Robin, Christine ^a,b   Beckerich, Florence ^a,b   Cordonnier, Catherine ^a,b  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

Cancer; Hematological malignancy; Immunedeficiency; Immunization; Infection; Vaccine

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; DIPHTHERIA PERTUSSIS POLIOMYELITIS TETANUS VACCINE; DIPHTHERIA POLIOMYELITIS TETANUS VACCINE; FLUDARABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE PLUS TETANUS TOXOID; HEPATITIS B VACCINE; IMMUNOLOGICAL ADJUVANT; IMMUNOMODULATING AGENT; INFLUENZA VACCINE; LENALIDOMIDE; LIVE VACCINE; MEASLES MUMPS RUBELLA VACCINE; MERCAPTOPURINE; METHOTREXATE; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE; PREDNISONE; PROTEIN TYROSINE KINASE INHIBITOR; RANITIDINE; RITUXIMAB; WART VIRUS VACCINE; VACCINE;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIBODY RESPONSE; ANTIBODY TITER; CANCER CHEMOTHERAPY; CANCER PATIENT; CONJUGATION; DOSAGE SCHEDULE COMPARISON; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HERD IMMUNITY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNIZATION; IMMUNOCOMPROMISED PATIENT; IMMUNOGENICITY; IMMUNOGLOBULIN DEFICIENCY; IMMUNOPATHOLOGY; INFLUENZA; LYMPHOPROLIFERATIVE DISEASE; MYELODYSPLASTIC SYNDROME; MYELOMA; NONHUMAN; PNEUMOCOCCAL INFECTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTOCOL COMPLIANCE; REVIEW; SEROCONVERSION; SINGLE DRUG DOSE; STEM CELL TRANSPLANTATION; NEOPLASMS; STANDARDS;

GUIDELINES AS TOPIC; HUMANS; IMMUNIZATION; NEOPLASMS; VACCINES;

EID: 84923309242     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.10.002     Document Type: Review

References (84)

1. J. Carbone, N. del Pozo, A. Gallego, and E. Sarmiento Immunological risk factors for infection after immunosuppressive and biologic therapies Exp Rev Anti Infect Ther 9 4 2011 405 413
2. A. Wong, T. Marrie, S. Garg, J. Kellner, G. Tyrrel, and S. Group Increased risk of invasive pneumococcal disease in haematological and solid-organ malignancies Epidemiol Infect 138 12 2010 1804 1810
3. C.D. Cooksley, E.B. Avritscher, B.N. Bekele, K.V. Rolston, J.M. Geraci, and L.S. Elting Epidemiology and outcomes of serious influenza-related infections in the cancer population Cancer 104 3 2005 618 628
4. C. Even, S. Bastuji-Garin, Y. Hicheri, C. Pautas, F. Botterel, and S. Maury Impact of invasive fungal infection on the chemotherapy schedule and event-free survival in acute leukemia patients who survive to invasive fungal infection: a case control study Haematologica 96 2 2011 337 341
5. P. Ljungman, C. Cordonnier, H. Einsele, J. Englund, C.M. Machado, and J. Storek Vaccination of hematopoietic cell transplant recipients Bone Marrow Transplant 44 8 2009 521 526
6. P. Ljungman, D. Engelhard, R. De la Camara, H. Einsele, A. Locasciulli, and R. Martino Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT Bone Marrow Transplant 35 2005 737 746
7. L. Rubin, M. Levin, P. Ljungman, E. Davies, R. Avery, and M. Tomblun 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host Clin Infect Dis 58 3 2014 309 318
8. M. Tomblyn, T. Chiller, H. Einsele, R. Gress, K. Sepkowitz, and J. Storek Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation Biol Bone Marrow Transplant 15 10 2009 1143 1238
9. T. Ercan, L. Soycan, H. Apak, T. Celkan, A. Ozkan, and E. Akdenizli Antibody titers and immune response to diphteria-tetanus-pertussis and measles-mumps-rubella vaccination in children treated for acute lymphoblastic leukemia J Pediatr Hematol Oncol 27 2005 273 277
10. T. Nordoy, A. Husebekk, I. Aaaberge, P. Jenum, H. Samdal, and L. Flugsrud Humoral immunity to viral and bacterial antigens in lymphoma patients 4-10 years after high-dose therapy with ABMT. Serological responses to revaccinations according to EBMT guidelines Bone Marrow Transplant 28 2001 681 687
11. C. Porter, K. Edwards, Y. Zhu, and H. Frangoul Immune responses to influenza immunization in children receiving maintenance chemotherapy for acute lymphoblastic leukemia Pediatr Blood Cancer 42 1 2004 36 40
12. M. Sinisalo, J. Aittoniemi, P. Oivanen, H. Kaeyhty, R. Oelander, and J. Vilpo Response to vaccination against different types of antigens in patients with chronic lymphocytic leukaemia Brit J Haematol 114 2001 107 110
13. H. Anderson, K. Petrie, C. Berrisford, A. Charlett, N. Thatcher, and M. Zambon Seroconversion after influenza vaccination in patients with lung cancer Br J Cancer 80 1/2 1999 219 220
14. S. Kathleen, F. Andrew, R. Erin, and W. Ellen Adverse Effects of Vaccines: Evidence and Causality 2012 The National Academies Press Washington, DC
15. A. Rezvani, and H. Deeg Introduction to hematopoietic cell transplantation 3rd ed. 2010 Lippincott Williams & Wilkins Philadelphia
16. D. Cheuk, A. Chiang, T. Lee, G. Chan, and S. Ha Vaccines for prophylaxis of viral infections in patients with hematological malignancies Cochrane Database Syst Rev 16 3 2011 CD006505
17. D. Engelhard, C. Cordonnier, P.J. Shaw, T. Parkalli, C. Guenther, and R. Martino Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey Br J Haematol 117 2 2002 444 450
18. R. Meisel, L. Kuypers, U. Dirksen, R. Schubert, B. Gruhn, and G. Strauss Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation Blood 109 6 2007 2322 2326
19. C. Cordonnier, M. Labopin, V. Chesnel, P. Ribaud, R. de la Camara, and R. Martino Immune response to the 23-valent polysaccharide vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipients: results from the EBMT IDWP01 trial Vaccine 28 15 2010 2730 2734
20. C. Cordonnier, M. Labopin, V. Chesnel, P. Ribaud, R. De La Camara, and R. Martino Randomized study of early versus late immunization with pneumococcal conjugate vaccine after allogeneic stem cell transplantation Clin Infect Dis 48 10 2009 1392 1401
21. P. Ljungman, V. Duraj, and L. Magnius Response to immunization against polio after allogeneic marrow transplantation Bone Marrow Transplant 7 2 1991 89 93
22. P. Ljungman, E. Fridell, B. Lönnqvist, P. Bolme, M. Böttiger, and G. Gahrton Efficacy and safety of vaccination of marrow transplant recipients with a live attenuated measles, mumps, and rubella vaccine J Infect Dis 159 1989 610 615
23. A. Nilsson, A. de Milito, P. Engström, M. Nordin, M. Narita, and L. Grillner Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity Pediatrics 109 6 2002 e91
24. M. Zignol, M. Peracchi, G. Tridello, M. Pillon, F. Fregonese, and R. D'Elia Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy Cancer 101 3 2004 635 641
25. D. Ortbals, H. Liebhaber, C. Presant, A.L. Van Amburg, and J. Lee Influenza immunization of adult patients with malignant diseases Ann Intern Med 87 5 1977 552 557
26. G. Grimfors, M. Söderqvist, G. Holm, A. Lefvert, and M. Björkholm Longitudinal study of class and subclass antibody response to pneumococcal vaccination with splenectomized individuals with special reference to patients with Hodgkin's disease Eur J Hematol 45 1990 101 108
27. S. Petrasch, O. Kuhnemund, A. Reinacher, M. Uppenkamp, R. Reinert, and W. Schmiegel Antibody responses of splenectomized patients with non-Hodgkin's lymphoma to immunization with polyvalent pneumococcal vaccines Clin Diagn Lab Immunol 4 6 1997 635 638
28. M. Hinge, H. Ingels, H. Slotved, and I. Molle Serologic response to a 23-valent pneumococcal vaccine administered prior to autologous stem cell transplantation in patients with multiple myeloma APMIS Suppl 120 11 2012 935 940
29. M.A. Hartkamp A1, G.T. Rijkers, H. van Velzen-Blad, and D.H. Biesma Antibody responses to pneumococcal and haemophilus vaccinations in patients with B-cell chronic lymphocytic leukaemia Vaccine 19 13-14 2001 1671 1677
30. D.M. Musher, S.B. Manoff, R.D. McFetridge, C.L. Liss, R.D. Marchese, and J. Raab Antibody persistence ten years after first and second doses of 23-valent pneumococcal polysaccharide vaccine, and immunogenicity and safety of second and third doses in older adults Hum Vaccin 7 9 2011 919 928
31. D. Kumar, B. Welsh, D. Siegal, M.H. Chen, and A. Humar Immunogenicity of pneumococcal vaccine in renal transplant recipients - three year follow-up of a randomized trial Am J Transplant 7 3 2007 633 638
32. J.C. King Jr., P.E. Vink, J.J. Farley, M. Parks, M. Smilie, and D. Madore Comparison of the safety and immunogenicity of a pneumococcal conjugate with a licensed polysaccharide vaccine in human immunodeficiency virus and non-human immunodeficiency virus-infected children Pediatr Infect Dis J 15 3 1996 192 196
33. K. Pauksen, V. Duraj, P. Ljungman, J. Sjölin, G. Oberg, and G. Lönnerholm Immunity to and immunization against measles, rubella and mumps in patients after autologous bone marrow transplantation Bone Marrow Transplant 9 1992 427 432
34. C. Machado, F. Goncalves, C. Pannuti, F.L. Dulley, and V.A. de Souza Measles in bone marrow transplant recipients during an outbreak in Sao Paulo Brazil Blood 99 2002 83 87
35. P. Ljungman, H. Nahi, and A. Linde Vaccination of patients with haematological malignancies with one or two doses of influenza vaccine: a randomised study Br J Haematol 130 1 2005 96 98
36. J. Burgos, M. Peñaranda, A. Payeras, A. Villoslada, A. Curran, and M. Garau Invasive pneumococcal disease in HIV-infected adults: clinical changes after the introduction of the pneumococcal conjugate vaccine in children J Acquir Immune Defic Syndr 59 1 2012 31 38
37. K.M. Edwards, M.A. Pung, L.M. Tomfohr, M.G. Ziegler, J.P. Campbell, and M.T. Drayson Acute exercise enhancement of pneumococcal vaccination response: a randomised controlled trial of weaker and stronger immune response Vaccine 30 45 2012 6389 6395
38. A. Egli, D. Santer, K. Barakat, M. Zand, A. Levin, and M. Vollmer Vaccine adjuvants - understanding molecular mechanisms to improve vaccines Swiss Med Wkly 144 2014 w13940
39. L. Manzoli, C. De Vito, G. Salanti, M. D'Addario, P. Villari, and J. Ioannidis Meta-analysis of the immunogenicity and tolerability of pandemic influenza A 2009 (H1N1) Vaccines PLoS ONE 6 9 2011 e24384
40. C. Durier, C. Desaints, F. Lucht, P. Girard, Y. Lévy, and T. May Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults AIDS 27 1 2013 87 93
41. H. de Lavallade, P. Garland, T. Sekine, K. Hoschler, D. Marin, and K. Stringaris Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host Haematologica 96 2 2011 307 314
42. M. Ditschkowski, A. Elmaagacli, and D. Beelen H1N1 in allogeneic stem cell recipients: courses of infection and influence of vaccination on graft-versus-host disease Ann Hematol 90 1 2011 117 118
43. B. Mohty, M. Bel, M. Vukicevic, M. Nagy, E. Levrat, and S. Meier Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients Haematologica 96 6 2011 896 904
44. A. Barra, C. Cordonnier, M.P. Preziosi, L. Intrator, L. Hessel, and B. Fritzell Immunogenicity of Haemophilus influenzae type B conjugate vaccine in allogeneic bone marrow recipients J Infect Dis 166 5 1992 1021 1028
45. D. Kumar, M.H. Chen, B. Welsh, D. Siegal, I. Cobos, and H.A. Messner A randomized, double-blind trial of pneumococcal vaccination in adult allogeneic stem cell transplant donors and recipients Clin Infect Dis 45 12 2007 1576 1582
46. G.S. Giebink, P.I. Warkentin, N.K. Ramsay, and J.H. Kersey Titers of antibody to pneumococci in allogeneic bone marrow transplant recipients before and after vaccination with pneumococcal vaccine J Infect Dis 154 4 1986 590 596
47. D.C. Molrine, J.H. Antin, E.C. Guinan, R.J. Soiffer, K. MacDonald, and R. Malley Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation Blood 101 3 2003 831 836
48. C. Chan, D. Molrine, S. George, N. Tarbell, P. Mauch, and L. Diller Pneumococcal conjugate vaccine primes for antibody responses to polysaccharide pneumococcal vaccine after treatment of Hodgkin's disease J Infect Dis 173 1996 256 258
49. K.L. O'Brien, M. Hochman, and D. Goldblatt Combined schedules of pneumococcal conjugate and polysaccharide vaccines: is hyporesponsiveness an issue? Lancet Infect Dis 7 9 2007 597 606
50. R. Engler, M. Nelson, M. Klote, M. VanRaden, C. Huang, and N. Cox Half- vs full-dose trivalent inactivated influenza vaccine (2004-2005): age, dose, and sex effects on immune responses Arch Intern Med 168 22 2008 2405 2414
51. J.Y. Song, H.J. Cheong, J.Y. Noh, T.U. Yang, Y.B. Seo, and K.W. Hong Long-term immunogenicity of the influenza vaccine at reduced intradermal and full intramuscular doses among healthy young adults Clin Exp Vaccine Res 2 2 2013 115 119
52. J. Treanor, W. Keitel, R. Belshe, J. Campbell, G. Schiff, and K. Zangwill Evaluation of a single dose of half strength inactivated influenza vaccine in healthy adults Vaccine 20 7-8 2002 1099 1105
53. M. Turchi, C. Martelli, M. Ferraz, A. Silva, D. Cardoso, and P. Martelli Immunogenicity of low-dose intramuscular and intradermal vaccination with recombinant hepatitis B vaccine Rev Inst Med Trop Sao Paulo 39 1 1997 15 19
54. S. Esposito, R. Prymula, G. Zuccotti, F. Xie, M. Barone, and P. Dull A phase II randomized controlled trial of a multicomponent meningococcal serogroup B vaccine, 4CMenB, in infants (II): effects of variations of the OMV and protein content on immunogenicity and reactogenicity Hum Vaccin Immunother 10 7 2014 [Epub ahead of print]
55. P. Ljungman, M. Wiklund-Hammarsten, V. Duraj, L. Hammarström, B. Lönnqvist, and T. Paulin Response to tetanus toxoid immunization after allogeneic bone marrow transplantation J Infect Dis 162 2 1990 496 500
56. N. Dhédin, A. Krivine, N. Le Corre, A. Mallet, B. Lioure, and J. Bay Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients Vaccine 32 2014 585 591
57. D. Engelhard, A. Nagler, I. Hardan, A. Morag, M. Aker, and H. Baciu Antibody response to a two-dose regimen of influenza vaccine in allogeneic T cell-depleted and autologous BMT recipients Bone Marrow Transplant 11 1 1993 1 5
58. D. Engelhard, Z. Zakay-Rones, M. Shapira, I. Resnick, D. Averbuch, and S. Grisariu The humoral immune response of hematopoietic stem cell transplantation recipients to AS03-adjuvanted A/California/7/2009 (H1N1)v-like virus vaccine during the 2009 pandemic Vaccine 29 9 2011 1777 1782
59. D. Engelhard, B. Mohty, R. De La Camara, C. Cordonnier, and P. Ljungman European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 (2011), on behalf of ECIL, a joint venture of EBMT, EORTC, ICHS, and ELN Transplant Infect Dis 15 3 2013 219 232
60. J.D. Robertson, K. Nagesh, S.N. Jowitt, M. Dougal, H. Anderson, and K. Mutton Immunogenicity of vaccination against influenza. Streptococcus pneumoniae and Haemophilus influenzae type B in patients with multiple myeloma Br J Cancer 82 7 2000 1261 1265
61. K. Pauksen, A. Linde, V. Hammarstrom, J. Sjolin, J. Carneskog, and G. Jonsson Granulocyte-macrophage colony-stimulating factor as immunomodulating factor together with influenza vaccination in stem cell transplant patients Clin Infect Dis 30 2000 342 348
62. A. Safdar, G. Rodriguez, A. Rueda, W. Wierda, A. Ferrajoli, and D. Musher Multiple-dose granulocyte-macrophage-colony stimulating factor plus 23-valent polysaccharide pneumococcal vaccine in patients with chronic lymphocytic leukemia: a prospective, randomized trial of safety and immunogenicity Cancer 113 2 2008 383 387
63. M. Yaʇci, K. Acar, G. Sucak, K. Yamaç, R. Haznedar, and B. Hepatitis virus vaccine in lymphoproliferative disorders: a prospective randomized study evaluating the efficacy of granulocyte-macrophage colony stimulating factor as a vaccine adjuvant Eur J Haematol 79 4 2007 292 296
64. R. Ramanathan, D. Potter, C. Belani, S. Jacobs, S. Gravenstein, and F. Lim Randomized trial of influenza vaccine with granulocyte-macrophage colony-stimulating factor or placebo in cancer patients J Clin Oncol 20 21 2002 4313 4318
65. M. Jutel, T. Wanatabe, M. Akdis, K. Blaser, and C. Akdis Immune regulation by histamine - opinion Curr Opin Immunol 14 2002 735 740
66. J. Jurlander, P. de Nully Brown, P. Skov, J. Henrichsen, I. Heron, and N. Obel Improved vaccination response during ranitidine treatment, and increased plasma histamine concentrations in patients with B cell chronic lymphocytic leukaemia Leukemia 9 1995 1902 1909
67. A. Mellemgaard, de Nullyy Brown, I. Heron, C. Geisler, M. Hansen, and F. Moesgaard Ranitidine improves the vaccination response in patients with chronic lymphocytic leukaemia - a randomized, controlled study Immunol Inf Dis 3 1993 109 111
68. A.M. Van der Velden, H. Van Velzen-Blad, A.M. Claessen, R. Van der Griend, R. Oltmans, and G.T. Rijkers The effect of ranitidine on antibody responses to polysaccharide vaccines in patients with B-cell chronic lymphocytic leukaemia Eur J Haematol 79 1 2007 47 52
69. K. Noonan, L. Rudraraju, A. Ferguson, A. Emerling, M. Pasetti, and C. Huff Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses Clin Cancer Res 18 5 2012 1426 1434
70. J. Storek, M. Dawson, L. Lim, B. Burman, T. Stevens-Ayers, and F. Viganego Efficacy of donor vaccination before hematopoietic cell transplantation and recipient vaccination both before and early after transplantation Bone Marrow Transplant 33 3 2004 337 346
71. D. Bedognetti, G. Zoppoli, C. Massucco, E. Zanardi, S. Zupo, and A. Bruzzone Impaired response to influenza vaccine associated with persistent memory B cell depletion in non-Hodgkin's lymphoma patients treated with rituximab-containing regimens J Immunol 186 2011 6044 6055
72. A. Berglund, L. Willen, L. Grodeberg, L. Skattum, H. Hagberg, and K. Pauksens The response to vaccination against influenza A(H1N1) 2009, seasonal influenza and Streptococcus pneumoniae in adult outpatients with ongoing treatment for cancer with and without rituximab Acta Oncol 28 May 2014 1 9 [Epub ahead of print]
73. O. Yri, D. Torfoss, O. Hungnes, A. Tierens, K. Waalen, and T. Nordøy Rituximab blocks protective serologic response to influenzaA(H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment Blood 118 26 2011 6769 6771
74. I. Nazi, J. Kelton, M. Larché, D. Snider, N. Heddle, and M. Crowther The effect of rituximab on vaccine responses in patients with immune thromocytopenia Blood 122 11 2013 1946 1953
75. B.N. Savani, S. Goodman, and A.J. Barrett Can routine posttransplant HPV vaccination prevent commonly occurring epithelial cancers after allogeneic stem cell transplantation? Clin Cancer Res 15 7 2009 2219 2221
76. B.N. Savani, P. Stratton, A. Shenoy, E. Kozanas, S. Goodman, and A.J. Barrett Increased risk of cervical dysplasia in long-term survivors of allogeneic stem cell transplantation - implications for screening and HPV vaccination Biol Blood Marrow Transplant 14 9 2008 1072 1075
77. S.K. Tedeschi, B.N. Savani, M. Jagasia, B. Engelhardt, C. Anasetti, and A.J. Barrett Time to consider HPV vaccination after allogeneic stem cell transplantation Biol Blood Marrow Transplant 16 8 2010 1033 1036
78. H. Yang, M. Huang, and D. Zhang Pneumococcal vaccination coverage in Medicaid-enrolled adults with high-risk conditions in the United States 9th International Symposium on Pneumococci and Pneumococcal Diseases Hyderabad, India. p. ISPPD-0438 2014
79. MMWR Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults with Immunocompromising Conditions: Recommendations of the Advisory Committee on Immunization Practices (ACIP) 2012 816 819
80. S.P. Ison MG1, M.Y. Shapira, G. Kriván, A. Nist, and R. Dutkowski Efficacy and safety of oral oseltamivir for influenza prophylaxis in transplant recipients Antivir Ther 17 6 2012 955 964
81. H.M. Chapel, M. Lee, R. Hargreaves, D.H. Pamphilon, and A.G. Prentice Randomised trial of intravenous immunoglobulin as prophylaxis against infection in plateau-phase multiple myeloma, the UK Group for Immunoglobulin Replacement Therapy in Multiple Myeloma Lancet 343 8905 1994 1059 1063
82. I. Sklenar, G. Schiffman, V. Jønsson, G. Verhoef, H. Birgens, and M. Boogaerts Effect of various doses of intravenous polyclonal IgG on in vivo levels of 12 pneumococcal antibodies in patients with chronic lymphocytic leukaemia and multiple myeloma Oncology 50 6 1993 466 477
83. A. Soriano, L. Jubierre, A. Almazan-Moga, C. Molist, J. Roma, and J. Sanchez de Toledo MicroRNA as pharmacological targets in cancer Pharmacol Res 75 2013 3 14
84. A. Montinaro, R. Iannone, A. Pinto, and S. Morello Adenosine receptors as potential targets in melanoma Pharmacol Res 76 2013 34 40