Clinical presentation of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections in research and community settings

Journal of Child and Adolescent Psychopharmacology

Volumn 25, Issue 1, 2015, Pages 26-30

  Swedo, Susan E ^a   Seidlitz, Jakob ^a   Kovacevic, Miro ^b,d   Latimer, M Elizabeth ^c,d   Hommer, Rebecca ^a   Lougee, Lorraine ^a   Grant, Paul ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Pediatrics and Child Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOIMMUNE DISEASE; CHILD; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL FEATURE; COMMUNITY CARE; COMORBIDITY; COMPARATIVE STUDY; DISEASE ASSOCIATION; GROUP A STREPTOCOCCAL INFECTION; HUMAN; MEDICAL DOCUMENTATION; MENTAL DISEASE; NATIONAL HEALTH ORGANIZATION; OBSESSIVE COMPULSIVE DISORDER; PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDERS ASSOCIATED WITH STREPTOCOCCAL INFECTION; SCHOOL; SEPARATION ANXIETY; SLEEP DISORDER; STREPTOCOCCUS INFECTION; SYSTEMATIC REVIEW; TIC; UROGENITAL TRACT DISEASE; ADOLESCENT; AUTOIMMUNE DISEASES; CLINICAL TRIAL; DEMOGRAPHY; FEMALE; MALE; MEDICAL RECORD; MULTICENTER STUDY; OBSESSIVE-COMPULSIVE DISORDER; PRESCHOOL CHILD; PSYCHOLOGY; STREPTOCOCCAL INFECTIONS; TIC DISORDERS;

ADOLESCENT; AUTOIMMUNE DISEASES; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; HUMANS; MALE; MEDICAL RECORDS; OBSESSIVE-COMPULSIVE DISORDER; RESIDENCE CHARACTERISTICS; STREPTOCOCCAL INFECTIONS; TIC DISORDERS;

EID: 84923297152     PISSN: 10445463     EISSN: 15578992     Source Type: Journal    
DOI: 10.1089/cap.2014.0073     Document Type: Article

References (23)

1. Allen AJ, Leonard HL, Swedo SE: Case study: A new infectiontriggered, autoimmune subtype of pediatric OCD and Tourette's Syndrome. J Am Acad Child Adolesc Psychiatry 34:307-311, 1995.
2. Gabbay V, Coffey BJ, Babb JS, Meyer L, Wachtel C, Anam S, Rabinovitz B: Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic. Pediatrics 122:273-278, 2008.
3. Garvey MA, Perlmutter SJ, Allen AJ, Hamburger S, Lougee L, Leonard HL, Witowski ME, Dubbert B, Swedo SE: A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Biol Psychiatry 45:1564-1571, 1999.
4. Gilbert DL, Kurlan R: PANDAS: Horse or zebra Neurology 73:1252-1253, 2009.
5. Hoekstra PJ, Minderaa RB, Kallenberg CG: Lack of effect of intravenous immunoglobulins on tics: a double-blind placebo-controlled study. J Clin Psychiatry 65:537-542, 2004.
6. Kirvan CA, Cox CJ, Swedo SE, Cunningham MW: Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J Immunol 178:7412-7421, 2007.
7. Kirvan CA, Swedo SE, Siner LA, Cunningham MW: Antibodymediated neuronal cell signaling in behavior and movement disorders. J Neuroimmunol 179:173-179, 2006.
8. Kurlan R: Tourette's syndrome and 'PANDAS': Will the relation bear out? Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Neurology 50:1530-1534, 1998.
9. Kurlan R, Kaplan EL: The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. Pediatrics 113:883-886, 2004.
10. Leckman JF, King RA, Gilbert DL, Coffey BJ, Singer HS, Dure LS 4th, Grantz H, Katsovich L, Lin H, Lombroso PJ, Kawikova I, Johnson DR, Kurlan RM, Kaplan EL: Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry 50:108-118.e.3, 2011.
11. Murphy ML, Pichichero ME: Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with Group A streptococcal infection (PANDAS). Arch Pediatr Adolesc Med 156:356-361, 2002.
12. Murphy TK, Storch EA, Lewin AB, Edge PJ, Goodman WK: Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Pediatrics 160:314-319, 2012.
13. Nicolson R, Swedo SE, Lenane M, Bedwell J, Wudarsky M, Gochman P, Hamburger SD, Rapoport JL: An open trial of plasma exchange in childhood-onset obsessive-compulsive disorder without poststreptococcal exacerbations. J Am Acad Child Adolesc Psychiatry 39:1313-1315, 2000.
14. Perlmutter SJ, Leitman SF, Garvey MA, Hamburger S, Feldman E, Leonard HL, Swedo SE: Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet 354:1153-1158, 1999.
15. Singer HS, Gause C, Morris C, Lopez P, Tourette Syndrome Study Group: Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. Pediatrics 121:1198-1205, 2008.
16. Singer HS, Gilbert DL, Wolf DS, Mink JW, Kurlan R: Moving from PANDAS to CANS. J Pediatr 160:725-731, 2012.
17. Erratum in J Pediatr 160:888, 2012.
18. Snider LA, Lougee L, Slattery M, Grant P, Swedo SE: Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry 57:788-792, 2005.
19. Swedo SE. Sydenham's chorea: A model for childhood autoimmune neuropsychiatric disorders. JAMA 272:1788-1791, 1994.
20. Swedo SE, Leckman JF, Rose NR: From research subgroup to clinical syndrome: Modifying the PANDAS criteria to describe PANS (pediatric acute-onset neuropsychiatric syndrome). Pediatr Therapeut 2:2, 2012.
21. Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J, Dubbert BK: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am J Psychiatry 155:264-271, 1998.
22. Erratum in Am J Psychiatry 155:578, 1998.
23. Swedo SE, Leonard HL, Rapoport JL: The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: Separating fact from fiction. Pediatrics 113:907-911, 2004.