The role of adjuvant therapy inthe management of head and neck merkel cell carcinoma: An analysis of 4815 patients

JAMA Otolaryngology - Head and Neck Surgery

Volumn 141, Issue 2, 2015, Pages 137-141

  Chen, Michelle M ^a   Roman, Sanziana A ^b   Sosa, Julie A ^b,c   Judson, Benjamin L ^d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADJUVANT CHEMORADIOTHERAPY; ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CHEMOSURGERY; CONTROLLED STUDY; FEMALE; HEAD AND NECK CARCINOMA; HEAD AND NECK MERKEL CELL CARCINOMA; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MERKEL CELL TUMOR; MIDDLE AGED; OVERALL SURVIVAL; POSTOPERATIVE CARE; RETROSPECTIVE STUDY; SURVIVAL TIME; TUMOR VOLUME; ADJUVANT THERAPY; AGE; CARCINOMA, MERKEL CELL; HEAD AND NECK NEOPLASMS; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; SEX DIFFERENCE;

AGE FACTORS; AGED; CARCINOMA, MERKEL CELL; CHEMORADIOTHERAPY, ADJUVANT; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; SEX FACTORS;

EID: 84923296348     PISSN: 21686181     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaoto.2014.3052     Document Type: Article

References (18)

1. Smith VA, Camp ER, Lentsch EJ. Merkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER data. Laryngoscope. 2012;122(6):1283-1290.
2. Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972;105(1):107-110.
3. Hodgson NC. Merkel cell carcinoma: changing incidence trends. J Surg Oncol. 2005;89(1):1-4.
4. Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008;58(3):375-381.
5. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096-1100.
6. Smith PD, Patterson JW. Merkel cell carcinoma (neuroendocrine carcinoma of the skin). Am J Clin Pathol. 2001;115(suppl):S68-S78.
7. Ruan JH, Reeves M. A Merkel cell carcinoma treatment algorithm. Arch Surg. 2009;144(6):582-585.
8. Poulsen M, Rischin D. Merkel cell carcinoma-current therapeutic options. Expert Opin Pharmacother. 2003;4(12):2187-2192.
9. Hasan S, Liu L, Triplet J, Li Z, Mansur D. The role of postoperative radiation and chemoradiation in Merkel cell carcinoma: a systematic review of the literature. Front Oncol. 2013;3:276.
10. Phillips J, Eremin D, Stewart A. National Cancer Data Base On-Line Data Dictionary, Beta-Test. Chicago, IL: American College of Surgeons, Commission on Cancer; 2011. http://ncdbpuf.facs.org/?q=node/259. Accessed October 8, 2013.
11. Winchester DP, Stewart AK, Phillips JL, Ward EE. The National Cancer Data Base: past, present, and future. Ann Surg Oncol. 2010;17(1):4-7.
12. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45 (6):613-619.
13. Lawenda BD, Arnold MG, Tokarz VA, et al. Analysis of radiation therapy for the control of Merkel cell carcinoma of the head and neck based on 36 cases and a literature review. Ear Nose Throat J. 2008;87(11):634-643.
14. Clark JR, Veness MJ, Gilbert R, O'Brien CJ, Gullane PJ. Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary? Head Neck. 2007;29(3):249-257.
15. Gillenwater AM, Hessel AC, Morrison WH, et al. Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg. 2001;127 (2):149-154.
16. Morand G, Vital D, Pézier T, et al. Merkel cell carcinoma of the head and neck: a single institutional experience. J Skin Cancer. 2013;2013:325086.
17. Mojica P, Smith D, Ellenhorn JDI. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Oncol. 2007;25(9):1043-1047.
18. Lewis KG, Weinstock MA, Weaver AL, Otley CC. Adjuvant local irradiation for Merkel cell carcinoma. Arch Dermatol. 2006;142(6):693-700.