Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation

Chemistry and Biology

Volumn 22, Issue 2, 2015, Pages 293-298

  Kudirka, Romas ^a   Barfield, Robyn M ^a   McFarland, Jesse ^a   Albers, Aaron E ^a   De Hart, Gregory W ^a   Drake, Penelope M ^a   Holder, Patrick G ^a   Banas, Stefanie ^a   Jones, Lesley C ^a   Garofalo, Albert W ^a   Rabuka, David ^a  

^a Redwood Bioscience Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; ANTINEOPLASTIC AGENT; CARBON; NUCLEOPHILE; PROTEIN; UNCLASSIFIED DRUG; CAC10-VCMMAE; PYRAZOLE DERIVATIVE; TRASTUZUMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYST; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; CYCLIZATION; DERIVATIZATION; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KNOEVENAGEL CONDENSATION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; NUCLEOPHILICITY; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; STOMACH TUMOR; TANDEM MASS SPECTROMETRY; TAUTOMER; TREATMENT DURATION; TUMOR REGRESSION; XENOGRAFT; CATALYSIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARBON; CATALYSIS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOCONJUGATES; PROTEINS; PYRAZOLES; TRASTUZUMAB;

EID: 84923247362     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.11.019     Document Type: Article

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