Effects of dexamethasone and cox inhibitors on intracranial pressure and cerebral perfusion in the lipopolysaccharide treated rats with hyperammonemia

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Rohde, Johan ^a   Pedersen, Hans R ^a   Bjerring, Peter N ^a   Larsen, Fin Stolze ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM ACETATE; DEXAMETHASONE; DICLOFENAC; INDOMETACIN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; 6 OXOPROSTAGLANDIN F1 ALPHA; AMMONIUM DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN PERFUSION; CISTERNA MAGNA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HYPERAMMONEMIA; INFLAMMATION; INTRACRANIAL PRESSURE; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; RAT; ANIMAL; BLOOD; BLOOD FLOW; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BRAIN CIRCULATION; DRUG EFFECTS; HEMODYNAMICS; METABOLISM; TIME;

RATTUS; RATTUS NORVEGICUS;

6-KETOPROSTAGLANDIN F1 ALPHA; AMMONIUM COMPOUNDS; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DICLOFENAC; HEMODYNAMICS; HYPERAMMONEMIA; INDOMETHACIN; INTRACRANIAL PRESSURE; LIPOPOLYSACCHARIDES; MALE; RATS; REGIONAL BLOOD FLOW; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923241579     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117416     Document Type: Article

References (28)

1. Blei AT (2005) The pathophysiology of brain edema in acute liver failure. Neurochem Int 47: 71-7. PMID: 15961187
2. Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P (1999) Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29: 648-53. PMID: 10051463
3. Jalan R (2003) Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis 23: 271-82. PMID: 14523680
4. Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A (2004) Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 41: 613-20. PMID: 15464242
5. Wright G, Davies NA, Shawcross DL, Hodges SJ, Zwingmann C, et al. (2007) Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 45 (6):1517-1526. PMID: 17523148
6. Zaki AE, Wardle EN, Canalese J, Ede RJ, Williams R (1983) Potential toxins of acute liver failure and their effects on blood-brain barrier permeability. Experientia 39: 988-91. PMID: 6884496
7. Schilling L, Wahl M (1999) Mediators of cerebral edema. Adv Exp Med Biol 474: 123-41. PMID: 10634998
8. Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7: 41-53. PMID: 16371949
9. Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, et al. (1999) The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages. Eur J Immunol 29: 3105-11. PMID: 10540321
10. Vaquero J, Polson J, Chung C, Helenowski I, Schiodt FV, et al. (2003) Infection and the progression of hepatic encephalopathy in acute liver failure. Gastroenterology 125: 755-64. PMID: 12949721
11. Mozes T, Zijlstra FJ, Heiligers JP, Saxena PR, Bonta IL (1991) Sequential release of eicosanoids during endotoxin-induced shock in anesthetized pigs. Prostaglandins Leukot Essent Fatty Acids 42: 209-16. PMID: 1651510
12. Pickard JD (1981) Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to cerebral metabolism. J Cereb Blood Flow Metab 1: 361-84. PMID: 6799530
13. Andresen J, Shafi NI, Bryan RM Jr (2006) Endothelial influences on cerebrovascular tone. J Appl Physiol 100: 318-27. PMID: 16357085
14. Farkas E, Sule Z, Toth-Szuki V, Matyas A, Antal P, et al. (2006) Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brain. Microvasc Res 72(3): 113-9 PMID: 16854437
15. Pedersen HR, Ring-Larsen H, Olsen NV, Larsen FS (2007) Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital. J Hepatol 47(2): 245-52. PMID: 17532089
16. Saija A, Princi P, Lanza M, Scalese M, Aramnejad E, et al. (1995) Systemic cytokine administration can affect blood-brain barrier permeability in the rat. Life Sci 56: 775-84. PMID: 7885193
17. Mastronardi CA, Yu WH, McCann S (2001) Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system. Neuroimmunomodulation 9: 148-56. PMID: 11752888
18. Trickler WJ, Mayhan WG, Miller DW (2005) Brain microvessel endothelial cell responses to tumor necrosis factor-alpha involve a nuclear factor kappa B (NF-kappaB) signal transduction pathway. Brain Res 1048: 24-31. PMID: 15916752
19. Chung C, Gottstein J, Blei AT (2001) Indomethacin prevents the development of experimental ammoniainduced brain edema in rats after portacaval anastomosis. Hepatology 34: 249-54. PMID: 11481608
20. Masferrer JL, Seibert K (1994) Regulation of prostaglandin synthesis by glucocorticoids. Receptor 4(1): 25-30. PMID: 8038703
21. Quintana A, Raczka E, Quintana MA (1988) Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats. Eur J Pharmacol 149: 385-8. PMID: 3137081
22. Wang Q, Paulson OB, Lassen NA (1993) Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? J Cereb Blood Flow Metab 13: 724-7. PMID: 8314925
23. Mark KS, Trickler WJ, Miller DW (2001) Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. J Pharmacol Exp Ther 297: 1051-8. PMID: 11356928
24. Chastre A, Bélanger M, Beauchesne E, Nquyen BN, Desjardins P, et al. (2012) Inflammatory cascade driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. PLoS One 7(11): e49670. doi: 10.1371/journal.pone.0049670 PMID: 23166746
25. Bemeur C, Butterworth RF (2013) Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema. Metab Brain Dis 28(2): 145-50. doi: 10.1007/s11011-012-9361-3 PMID: 23212479
26. Possamai LA, Thursz MR, Wendon JA, Antoniades CG (2014) Modulation of monocyt/macrophage function: A therapeutic strategy in the treatment of acute liver failure. J Hepatol 61: 439-445. doi: 10.1016/j.jhep.2014.03.031 PMID: 24703954
27. Godoy DA, Alvarez E, Manzi R, Piñero G, Di Napoli M (2014) The physiological effects of indomethacin test on CCP and ICP in severe traumatic brain injury (sTBI). Neuricrit Care 20(2): 230-9.
28. Van Damme E, Sauviller S, Lau B, Kesteleyn B, Griffiths P, et al. (2015) Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients. J Gen Virol. 96(Pt 1): 131-43. doi: 10.1099/vir.0. 069872-0 PMID: 25312585