Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy

Journal of Clinical Oncology

Volumn 33, Issue 6, 2015, Pages 588-593

  Koppelmans, Vincent ^a,b,c   Vernooij, Meike W ^b   Boogerd, Willem ^c   Seynaeve, Caroline ^b   Ikram, M Arfan ^b   Breteler, Monique M B ^d   Schagen, Sanne B ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE;

ADULT; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVOR; CAROTID ARTERY; CEREBROVASCULAR DISEASE; COGNITION; COMPUTER PROGRAM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; HUMAN; LACUNAR STROKE; MAJOR CLINICAL STUDY; MULTIMODAL IMAGING; MULTIPLE CYCLE TREATMENT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PREVALENCE; PRIORITY JOURNAL; RADIATION EXPOSURE; VERBAL MEMORY; WHITE MATTER LESION; ADJUVANT CHEMORADIOTHERAPY; ADVERSE EFFECTS; AGED; BREAST NEOPLASMS; CASE CONTROL STUDY; CEREBRAL HEMORRHAGE; COMPLICATION; DRUG EFFECTS; ISCHEMIC ATTACK, TRANSIENT; MICROCIRCULATION; MIDDLE AGED; RADIATION RESPONSE; SURVIVOR;

AGED; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CEREBRAL HEMORRHAGE; CHEMORADIOTHERAPY, ADJUVANT; FEMALE; HUMANS; ISCHEMIC ATTACK, TRANSIENT; MICROCIRCULATION; MIDDLE AGED; SURVIVORS;

EID: 84923148254     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2014.56.8345     Document Type: Article

References (52)

1. de Ruiter MB, Schagen SB: Functional MRI studies in non-CNS cancers. Brain Imaging Behav 7:388-408, 2013
2. Deprez S, Billiet T, Sunaert S, et al: Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: A review. Brain Imaging Behav 7:409-435, 2013
3. Simó M, Rifà-Ros X, Rodriguez-Fornells A, et al: Chemobrain: A systematic review of structural and functional neuroimaging studies. Neurosci Biobehav Rev 37:1311-1321, 2013
4. Brown MS, Stemmer SM, Simon JH, et al: White matter disease induced by high-dose chemotherapy: Longitudinal study with MR imaging and proton spectroscopy. AJNR Am J Neuroradiol 19:217-221, 1998
5. Choi SM, Lee SH, Yang YS, et al: 5-fluorouracil-induced leukoencephalopathy in patients with breast cancer. J Korean Med Sci 16:328-334, 2001
6. de Ruiter MB, Reneman L, Boogerd W, et al: Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging. Hum Brain Mapp 33:2971-2983, 2012
7. Ferguson RJ, McDonald BC, Saykin AJ, et al: Brain structure and function differences in monozygotic twins: Possible effects of breast cancer chemotherapy. J Clin Oncol 25:3866-3870, 2007
8. Linnebank M, Moskau S, Jürgens A, et al: Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma. Neuro Oncol 11:2-8, 2009
9. Koppelmans V, Breteler MM, Boogerd W, et al: Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. Crit Rev Oncol Hematol 88:87-101, 2013
10. Seigers R, Fardell JE: Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research. Neurosci Biobehav Rev 35:729-741, 2011
11. Silverman DH, Dy CJ, Castellon SA, et al: Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy. Breast Cancer Res Treat 103:303-311, 2007
12. Hooning MJ, Dorresteijn LD, Aleman BM, et al: Decreased risk of stroke among 10-year survivors of breast cancer. J Clin Oncol 24:5388-5394, 2006
13. Nilsson G, Holmberg L, Garmo H, et al: Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke. Br J Cancer 100:811-816, 2009
14. Jagsi R, Griffith KA, Koelling T, et al: Stroke rates and risk factors in patients treated with radiation therapy for early-stage breast cancer. J Clin Oncol 24:2779-2785, 2006
15. Woodward WA, Giordano SH, Duan Z, et al: Supraclavicular radiation for breast cancer does not increase the 10-year risk of stroke. Cancer 106:2556-2562, 2006
16. Gujral DM, Shah BN, Chahal NS, et al: Clinical features of radiation-induced carotid atherosclerosis. Clin Oncol (R Coll Radiol) 26:94-102, 2014
17. KalábovaH, Melichar B, Ungermann L, et al: Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy. Med Oncol 28:1281-1287, 2011
18. Woodward WA, Durand JB, Tucker SL, et al: Prospective analysis of carotid artery flow in breast cancer patients treated with supraclavicular irradiation 8 or more years previously: No increase in ipsilateral carotid stenosis after radiation noted. Cancer 112:268-273, 2008
19. Silvestrini M, Vernieri F, Pasqualetti P, et al: Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis. JAMA 283:2122-2127, 2000
20. Handa N, Matsumoto M, Maeda H, et al: Ischemic stroke events and carotid atherosclerosis. Results of the Osaka Follow-up Study for Ultrasonographic Assessment of Carotid Atherosclerosis (the OSACA Study). Stroke 26:1781-1786, 1995
21. Agabiti-Rosei E, Muiesan ML: Carotid atherosclerosis, arterial stiffness and stroke events. Adv Cardiol 44:173-186, 2007
22. Pantoni L: Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689-701, 2010
23. van Norden AG, de Laat KF, Gons RA, et al: Causes and consequences of cerebral small vessel disease: The RUN DMC study - A prospective cohort study: Study rationale and protocol. BMC Neurol 11:29, 2011
24. Bonita R, Pradhan R: Cardiovascular toxicities of cancer chemotherapy. Semin Oncol 40:156-167, 2013
25. Jain M, Townsend RR: Chemotherapy agents and hypertension: A focus on angiogenesis blockade. Curr Hypertens Rep 9:320-328, 2007
26. Haugnes HS, Wethal T, Aass N, et al: Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: A 20-year follow-up study. J Clin Oncol 28:4649-4657, 2010
27. Koppelmans V, Breteler MM, Boogerd W, et al: Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J Clin Oncol 30:1080-1086, 2012
28. Koppelmans V, de Ruiter MB, van der Lijn F, et al: Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat 132:1099-1106, 2012
29. Koppelmans V, de Groot M, de Ruiter MB, et al: Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy. Hum Brain Mapp 35:889-899, 2014
30. Koppelmans V, Schagen SB, Poels MM, et al: Incidental findings on brain magnetic resonance imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. Eur J Cancer 47:2531-2536, 2011
31. Hofman A, van Duijn CM, Franco OH, et al: The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol 26:657-686, 2011
32. Ikram MA, van der Lugt A, Niessen WJ, et al: The Rotterdam Scan Study: Design and update up to 2012. Eur J Epidemiol 26:811-824, 2011
33. Vernooij MW, Ikram MA, Wielopolski PA, et al: Cerebral microbleeds: Accelerated 3D T2∗-weighted GRE MR imaging versus conventional 2D T2∗-weighted GRE MR imaging for detection. Radiology 248:272-277, 2008
34. Vernooij MW, van der Lugt A, Ikram MA, et al: Prevalence and risk factors of cerebral microbleeds: The Rotterdam Scan Study. Neurology 70:1208-1214, 2008
35. Poels MM, Vernooij MW, Ikram MA, et al: Prevalence and risk factors of cerebral microbleeds: An update of the Rotterdam scan study. Stroke 41:S103-S106, 2010 (suppl)
36. de Boer R, Vrooman HA, van der Lijn F, et al: White matter lesion extension to automatic brain tissue segmentation on MRI. Neuroimage 45:1151-1161, 2009
37. Cocosco CA, Zijdenbos AP, Evans AC: A fully automatic and robust brain MRI tissue classification method. Med Image Anal 7:513-527, 2003
38. de Boer R, Vrooman HA, Ikram MA, et al: Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods. Neuroimage 51:1047-1056, 2010
39. Lewinsohn PM, Seeley JR, Roberts RE, et al: Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults. Psychol Aging 12:277-287, 1997
40. Yates PA, Villemagne VL, Ellis KA, et al: Cerebral microbleeds: A review of clinical, genetic, and neuroimaging associations. Front Neurol 4:205, 2014
41. Soultati A, Mountzios G, Avgerinou C, et al: Endothelial vascular toxicity from chemotherapeutic agents: Preclinical evidence and clinical implications. Cancer Treat Rev 38:473-483, 2012
42. Saba L, Montisci R, Raz E, et al: Association between carotid artery plaque type and cerebral microbleeds. AJNR Am J Neuroradiol 33:2144-2150, 2012
43. de Leeuw FE, de Groot JC, Achten E, et al: Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study - The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 70:9-14, 2001
44. Wefel JS, Vardy J, Ahles T, et al: International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol 12:703-708, 2011
45. Wefel JS, Schagen SB: Chemotherapyrelated cognitive dysfunction. Curr Neurol Neurosci Rep 12:267-275, 2012
46. Lei C, Lin S, Tao W, et al: Association between cerebral microbleeds and cognitive function: A systematic review. J Neurol Neurosurg Psychiatry 84:693-697, 2013
47. Poels MM, Ikram MA, van der Lugt A, et al: Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study. Neurology 78:326-333, 2012
48. Yeh ET, Bickford CL: Cardiovascular complications of cancer therapy: Incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 53:2231-2247, 2009
49. Jimenez RB, Goma C, Nyamwanda J, et al: Intensity modulated proton therapy for postmastectomy radiation of bilateral implant reconstructed breasts: A treatment planning study. Radiother Oncol 107:213-217, 2013
50. Nishikawa T, Ueba T, Kajiwara M, et al: Cerebral microbleeds predict first-ever symptomatic cerebrovascular events. Clin Neurol Neurosurg 111:825-828, 2009
51. Nighoghossian N, Hermier M, Adeleine P, et al: Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: A gradientecho T2∗-weighted brain MRI study. Stroke 33:735-742, 2002
52. Fan YH, Zhang L, Lam WW, et al: Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 34:2459-2462, 2003