-
1
-
-
84923118622
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer JN, Dudley ME, Kassim SH, et al: Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 33:540-549, 2015
-
(2015)
J Clin Oncol
, vol.33
, pp. 540-549
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Kassim, S.H.3
-
2
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
Kochenderfer JN, Wilson WH, Janik JE, et al: Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116:4099-4102, 2010
-
(2010)
Blood
, vol.116
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
Wilson, W.H.2
Janik, J.E.3
-
3
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
-
Kochenderfer JN, Dudley ME, Feldman SA, et al: B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119:2709-2720, 2012
-
(2012)
Blood
, vol.119
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Feldman, S.A.3
-
4
-
-
84923170365
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukemia in children and young adults: A phase I dose-escalation trial
-
epub ahead of print on October 10, 2014
-
Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al: T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukemia in children and young adults: A phase I dose-escalation trial. Lancet [epub ahead of print on October 10, 2014]
-
Lancet
-
-
Lee, D.W.1
Kochenderfer, J.N.2
Stetler-Stevenson, M.3
-
5
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
Brentjens RJ, Rivière I, Park JH, et al: Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118:4817-4828, 2011
-
(2011)
Blood
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
Rivière, I.2
Park, J.H.3
-
6
-
-
84876005284
-
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
-
Brentjens RJ, Davila ML, Riviere I, et al: CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 5:177ra138, 2013
-
(2013)
Sci Transl Med
, vol.5
, pp. 177ra138
-
-
Brentjens, R.J.1
Davila, M.L.2
Riviere, I.3
-
7
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila ML, Riviere I, Wang X, et al: Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 6:224ra225, 2014
-
(2014)
Sci Transl Med
, vol.6
, pp. 224ra225
-
-
Davila, M.L.1
Riviere, I.2
Wang, X.3
-
8
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter DL, Levine BL, Kalos M, et al: Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365:725-733, 2011
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
-
9
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp SA, Kalos M, Barrett D, et al: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368:1509-1518, 2013
-
(2013)
N Engl J Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
-
10
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
Kalos M, Levine BL, Porter DL, et al: T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 3:95ra73, 2011
-
(2011)
Sci Transl Med
, vol.3
, pp. 95ra73
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
-
11
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, et al: Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 371:1507-1517, 2014
-
(2014)
N Engl J Med
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
-
12
-
-
0037441593
-
T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
-
Cooper LJ, Topp MS, Serrano LM, et al: T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect. Blood 101:1637-1644, 2003
-
(2003)
Blood
, vol.101
, pp. 1637-1644
-
-
Cooper, L.J.1
Topp, M.S.2
Serrano, L.M.3
-
13
-
-
0028902765
-
Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes
-
Brocker T, Karjalainen K: Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181:1653-1659, 1995
-
(1995)
J Exp Med
, vol.181
, pp. 1653-1659
-
-
Brocker, T.1
Karjalainen, K.2
-
14
-
-
0037348324
-
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
-
Brentjens RJ, Latouche JB, Santos E, et al: Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 9:279-286, 2003
-
(2003)
Nat Med
, vol.9
, pp. 279-286
-
-
Brentjens, R.J.1
Latouche, J.B.2
Santos, E.3
-
15
-
-
34848842554
-
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
-
Brentjens RJ, Santos E, Nikhamin Y, et al: Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res 13:5426-5435, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5426-5435
-
-
Brentjens, R.J.1
Santos, E.2
Nikhamin, Y.3
-
16
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
Till BG, Jensen MC, Wang J, et al: Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112:2261-2271, 2008
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
-
17
-
-
70350726110
-
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
-
Milone MC, Fish JD, Carpenito C, et al: Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther 17:1453-1464, 2009
-
(2009)
Mol Ther
, vol.17
, pp. 1453-1464
-
-
Milone, M.C.1
Fish, J.D.2
Carpenito, C.3
-
18
-
-
33845294816
-
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
-
Kowolik CM, Topp MS, Gonzalez S, et al: CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res 66:10995-11004, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 10995-11004
-
-
Kowolik, C.M.1
Topp, M.S.2
Gonzalez, S.3
-
19
-
-
79955517235
-
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
-
Savoldo B, Ramos CA, Liu E, et al: CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest 121:1822-1826, 2011
-
(2011)
J Clin Invest
, vol.121
, pp. 1822-1826
-
-
Savoldo, B.1
Ramos, C.A.2
Liu, E.3
-
20
-
-
62549097817
-
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
-
Carpenito C, Milone MC, Hassan R, et al: Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci U S A 106:3360-3365, 2009
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3360-3365
-
-
Carpenito, C.1
Milone, M.C.2
Hassan, R.3
-
21
-
-
76349087378
-
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3-kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
-
Zhong XS, Matsushita M, Plotkin J, et al: Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3-kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol Ther 18:413-420, 2010
-
(2010)
Mol Ther
, vol.18
, pp. 413-420
-
-
Zhong, X.S.1
Matsushita, M.2
Plotkin, J.3
-
22
-
-
74949124101
-
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies
-
Tammana S, Huang X, Wong M, et al: 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies. Hum Gene Ther 21:75-86, 2010
-
(2010)
Hum Gene Ther
, vol.21
, pp. 75-86
-
-
Tammana, S.1
Huang, X.2
Wong, M.3
-
23
-
-
34548485103
-
Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
-
Wang J, Jensen M, Lin Y, et al: Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum Gene Ther 18:712-725, 2007
-
(2007)
Hum Gene Ther
, vol.18
, pp. 712-725
-
-
Wang, J.1
Jensen, M.2
Lin, Y.3
-
24
-
-
84860333968
-
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
-
Till BG, Jensen MC, Wang J, et al: CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results. Blood 119:3940-3950, 2012
-
(2012)
Blood
, vol.119
, pp. 3940-3950
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
-
25
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen MC, Popplewell L, Cooper LJ, et al: Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant 16:1245-1256, 2010
-
(2010)
Biol Blood Marrow Transplant
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
-
26
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, et al: Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 18:843-851, 2010
-
(2010)
Mol Ther
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
|