MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/c-MET/AKT pathway

Cellular Physiology and Biochemistry

Volumn 35, Issue 3, 2015, Pages 983-996

  Yao, Yingmin ^a   Dou, Chanwei ^a   Lu, Zhongtang ^a   Zheng, Xin ^a   Liu, Qingguang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

AKT; Apoptosis; Hepatocellular carcinoma; HGF c MET signaling; MACC1

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; HYPOXIA INDUCIBLE FACTOR; LIPOCORTIN 5; MESSENGER RNA; METASTASIS ASSOCIATED WITH COLON CANCER 1 PROTEIN; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; TUMOR MARKER; UNCLASSIFIED DRUG; BAD PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; HGF PROTEIN, HUMAN; MACC1 PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; SCATTER FACTOR; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CELL CULTURE; CELL GROWTH; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KAPLAN MEIER METHOD; LIVER CELL CARCINOMA; LIVER RESECTION; MTT ASSAY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

MUS MUSCULUS;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE GROWTH FACTOR; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MICE; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-MET; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84923113824     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369754     Document Type: Article

References (22)

1. Bosch FX, Ribes J, Diaz M, Cleries R: Primary liver cancer: Worldwide incidence and trends. Gastroenterology 2004;127:S5-S16.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
3. Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM: Macc1, a newly identified key regulator of hgf-met signaling, predicts colon cancer metastasis. Nature Medicine 2009;15:59-67.
4. Forte G, Minieri M, Cossa P, Antenucci D, Sala M, Gnocchi V, Fiaccavento R, Carotenuto F, De Vito P, Baldini PM, Prat M, Di Nardo P: Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation. Stem Cells 2006;24:23-33.
5. Ma PC, Maulik G, Christensen J, Salgia R: C-met: Structure, functions and potential for therapeutic inhibition. Cancer & Metastasis Reviews 2003;22:309-325.
6. Whittaker S, Marais R, Zhu AX: The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010;29:4989-5005.
7. Graziani A, Gramaglia D, Cantley LC, Comoglio PM: The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem 1991;266:22087-22090.
8. Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G, Comoglio PM: A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994;77:261-271.
9. Sakamaki J, Daitoku H, Ueno K, Hagiwara A, Yamagata K, Fukamizu A: Arginine methylation of bcl-2 antagonist of cell death (bad) counteracts its phosphorylation and inactivation by akt. Proc Natl Acad Sci USA 2011;108:6085-6090.
10. Uddin S, Kottegoda S, Stigger D, Platanias LC, Wickrema A: Activation of the akt/fkhrl1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors. Biochem Biophys Res Commun 2000;275:16-19.
11. Gao J, Ding F, Liu Q, Yao Y: Knockdown of macc1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of mmp2 and mmp9. Mol Cell Biochem 2013;376:21-32.
12. Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR: The transcription factor gli1 mediates tgfbeta1 driven emt in hepatocellular carcinoma via a snai1-dependent mechanism. PLoS One 2012;7:e49581.
13. Zheng X, Gai X, Ding F, Lu Z, Tu K, Yao Y, Liu Q: Histone acetyltransferase pcaf up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone h4 and inactivating akt signaling. Mol Cancer 2013;12:96.
14. Siegel R, Naishadham D, Jemal A: Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
15. Gluer AM, Cocco N, Laurence JM, Johnston ES, Hollands MJ, Pleass HC, Richardson AJ, Lam VW: Systematic review of actual 10-year survival following resection for hepatocellular carcinoma. HPB (Oxford) 2012;14:285-290.
16. Qiu J, Huang P, Liu Q, Hong J, Li B, Lu C, Wang L, Wang J, Yuan Y: Identification of macc1 as a novel prognostic marker in hepatocellular carcinoma. Journal of Translational Medicine 2011;9:166.
17. Xie C, Wu J, Yun J, Lai J, Yuan Y, Gao Z, Li M, Li J, Song L: Macc1 as a prognostic biomarker for early-stage and afp-normal hepatocellular carcinoma. PLoS One 2013;8:e64235.
18. Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K: Macc1 as a marker for advanced colorectal carcinoma. Anticancer research 2010;30:2689-2692.
19. Stein U, Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Schlag PM: Circulating macc1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PLoS One 2012;7:e49249.
20. Wang G, Kang MX, Lu WJ, Chen Y, Zhang B, Wu YL: Macc1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance. Oncology Letters 2012;4:783-791.
21. Wang L, Wu Y, Lin L, Liu P, Huang H, Liao W, Zheng D, Zuo Q, Sun L, Huang N, Shi M, Liao Y: Metastasis-associated in colon cancer-1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. Int J Cancer 2013;133:1419-1430.
22. Zhang Y, Wang Z, Chen M, Peng L, Wang X, Ma Q, Ma F, Jiang B: Microrna-143 targets macc1 to inhibit cell invasion and migration in colorectal cancer. Molecular Cancer 2012;11:23.